Low Relapse Rate in Children With Acute Lymphoblastic Leukemia After Risk-Directed Therapy

Abstract

The modification proved to be effective in diminishing the therapeutic toxicity and improving the efficacy, mainly for the high-risk group.

Serial Plasma Concentrations of Adiponectin, Leptin, and Resistin During Therapy in Children With Acute Lymphoblastic Leukemia

“…8,9 This protocol includes corticosteroids for all the patients both in induction-consolidation phase and maintenance phase. Patients with clinical or radiologic findings of acute or chronic infection were excluded.…”

“…The interval between the completion of last chemotherapy regimen and blood sample collection was at least 2 weeks. 9 Physical examination, including BMI measurement, was performed at the same time points. BMI SD (standard deviation) scores were determined calculating the SD from the mean value of BMI for the respective age and sex of every individual.…”

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

“…Survival figures for certain hematological malignancies have improved dramatically: 5-year survival from childhood acute lymphoblastic leukemia was less than 40% in the 1970s, while is now approaching 80%. 1,2 However, the chemotherapeutic treatment outcome for most adults with acute myeloid leukemia remains unacceptable. 3 Indeed, it seems that we have reached the limits of our ability to kill cancer cells that are intrinsically resistant to chemotherapy.…”

Could intensified treatment in childhood acute lymphoblastic leukemia improve outcome independently of risk factors?

“…In HOPDA‐91 (1991–1993, Table 1), LR patients received a combination of UKALL XI (induction) and R blocks of ALL‐REZ BFM‐87 (intensification) whereas HR patients received the NY II regimen (13). However, four cases, all in the HR group, died during the consolidation phase due to complications (three septicemias, one Aspergillus fumigatus infection) (14). Furthermore, a boy with LR leukemia had an early relapse but achieved a second remission.…”