Low recovery rates of high-level aminoglycoside-resistant enterococci could be attributable to restricted usage of aminoglycosides in Indian settings

Abstract

Low recovery rates of high-level aminoglycoside-resistant enterococci could be attributable to restricted usage of aminoglycosides in Indian settings

Clinico-epidemiological profile and high-level aminoglycoside resistance in enterococcal septicemia from a tertiary care hospital in east Delhi

“…[7] E. faecium leading to bacteremia was higher in prevalence than E. fecalis (53% and 33%, respectively) in this study, and prevalence of relatively high proportion of E. faecium from the study setting was consistent with those reported in other Indian studies from various clinical samples (40–71%). [8–10]…”

“…Reports of the steady rise in the recovery rates of ampicillin-resistant enterococci (ARE) have been available in the recent past in India. [10] Many studies have also demonstrated that E. faecium is comparatively more resistant than E. faecalis . [10111213] In the present study, resistance rates for ampicillin, penicillin and chloramphenicol were comparable in E. faecium and E. faecalis ; while E. faecium showed higher rates of resistance to erythromycin, amoxycillin–clavunate, ciprofloxacin, tetracycline and imepenam.…”

“…[10] Many studies have also demonstrated that E. faecium is comparatively more resistant than E. faecalis . [10111213] In the present study, resistance rates for ampicillin, penicillin and chloramphenicol were comparable in E. faecium and E. faecalis ; while E. faecium showed higher rates of resistance to erythromycin, amoxycillin–clavunate, ciprofloxacin, tetracycline and imepenam. Frequent use of ampicillin, macrolides and quinolones for the empirical treatment of endemic infectious diseases and for treatment of enterococcal infections may be the cause of the high proportion of antibiotic resistant pattern seen in the isolates.…”

“…A recent study from South India reported a low fecal carriage of 2% and 4% of HLGR and HLSR enterococci, respectively. [10] HLAR was more frequently observed in E. faecium isolates (71%) than other species. Previous studies on HLAR have been done almost exclusively on E. faecalis .…”

Antibiogram of Enterococcal Species Isolated From Clinical Specimens in a Tertiary Care Teaching Hospital

“…Reports of the steady rise in the recovery rates of Ampicillin-Resistant Enterococci (ARE) have been available in the recent past in India. 15 Among quinolones, least sensitivity was observed with ciprofloxacin. Similar low sensitivity with ciprofloxacin was reported by Subbalaxami et al 16 High-Level Resistance to Aminoglycosides (HLAR) is of great clinical concern since it eliminates synergy with cell wall active antibiotics, which renders treatment of serious enterococcal infections difficult.…”