Low Prevalence of Severe Underlying Pathology in Children With Recurrent Respiratory Tract Infections

Peeters, Daphne; Verhulst, Pieter; Vaessen-Verberne, Anja; Tweel, Xandra W. van den; Noordzij, Jeroen G.

doi:10.1097/inf.0000000000003256

Cited by 2 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 35 ] There are more and more studies applying mNGS to the diagnosis of clinical infectious diseases, among which the research of this technology in respiratory diseases has become a recent research hotspot. [ 36 ] New technologies bring hope to overcome the technical bottleneck of mNGS detection timeliness. A newly developed nanopore sequencing method for bacterial LRTI is reported to effectively remove host DNA and accurately identify pathogens and pathogens within 6 hours.…”

Section: Discussionmentioning

confidence: 99%

Using targeted second-generation sequencing technique to guide clinical diagnosis and the effect of medication on the therapeutic effect and prognosis of respiratory tract infection in children: An observational study

Lian,

Tang,

et al. 2024

Medicine

View full text Add to dashboard Cite

To explore the effect of targeted second-generation sequencing technique to guide clinical diagnosis and medication on the therapeutic effect and prognosis of respiratory tract infection (RTI) in children. During January 2021 to June 2022, 320 children with RTI cured were selected in our hospital as the object of this retrospective study. The control group accepted empirical broad-spectrum antibacterial therapy and the observation group accepted targeted second-generation sequencing technique to guide diagnosis and medication. The therapeutic effect, improvement time of clinical symptom index, laboratory-related index, level of inflammatory factors, incidence of complications, and parents’ treatment satisfaction were compared. The observation group was considerably more efficacious (91.25%) versus the controlled group (72.50%). The duration of enhancement of fever, nasal congestion, tonsillar congestion, and cough symptoms was shorter in the observation group (P < .05). Serum levels of iron, IgA, IgG as well as IgM were substantially elevated in the observation group. The levels of IL-4 and IL-10 were markedly reduced in the observation group after treatment. The prevalence of complications was considerably below that of the comparison group (21.25%) in the observation group (8.75%). Parental satisfaction with therapy was markedly higher in the observation group (92.50%) than in the control group (66.25%). The application of targeted second-generation sequencing technology to guide clinical diagnosis and drug use can elevate the RTIs efficacy and prognosis in childhood. Targeted second-generation sequencing can achieve precise treatment, reduce drug resistance of drug-resistant strains, and improve the efficacy. It has high promotion and application value.

show abstract

Section: Discussionmentioning

confidence: 99%

Using targeted second-generation sequencing technique to guide clinical diagnosis and the effect of medication on the therapeutic effect and prognosis of respiratory tract infection in children: An observational study

Lian,

Tang,

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

“…In the setting of a worsening recurrence of infections, hypogammaglobulinemia was observed, and an extensive immunological work-up allowed a clinical diagnosis of Common Variable Immunodeficiency (CVID) and genetic analysis identified a novel heterozygous variant in IKBKB gene. Infectious recurrence, mainly involving the respiratory tract, represent an extremely common feature during pediatric age (11) with approximately of children <10 years of age suffering from recurrent respiratory tract infections, requiring antibiotic treatment and, in some cases, hospitalization (12). Many children with IEI conditions may remain undiagnosed or misdiagnosed for a longtime since infections might be underestimated and each infection treated as an isolated episode while the underlying cause and appropriate investigations are missed.…”

Section: Discussionmentioning

confidence: 99%

“…Infectious recurrence, mainly involving the respiratory tract, represent an extremely common feature during pediatric age ( 11 ) with approximately 10%–20% of children <10 years of age suffering from recurrent respiratory tract infections, requiring antibiotic treatment and, in some cases, hospitalization ( 12 ). Many children with IEI conditions may remain undiagnosed or misdiagnosed for a longtime since infections might be underestimated and each infection treated as an isolated episode while the underlying cause and appropriate investigations are missed.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Crossing a rugged road in a primary immune regulatory disorder

Sgrulletti

Cifaldi²,

Cesare³

et al. 2023

Front. Pediatr.

View full text Add to dashboard Cite

Over the last decades, Inborn Errors of Immunity (IEI) characterized by an immune dysregulatory picture, isolated or combined with infections, have been increasingly identified and referred as Primary Immune Regulatory Disorders (PIRD). PIRD diagnosis may be difficult due to heterogeneity of time onset, sequence of clinical manifestations and laboratory abnormalities. Moreover, the dissection of a PIRD vs. a secondary immunodeficiency (SID) might be a real challenge since the same indications for immunosuppressant treatments might represent per se a PIRD clinical expression. Here we report a female patient with a history of recurrent respiratory and urinary tract infections since early infancy and a diagnosis of Rheumatoid Arthritis in adulthood. After poor response to several biologicals she was treated with Rituximab and sent to immunology referral for a severe hypogammaglobulinemia. Clinical and immunological features matched a diagnosis of common variable immunodeficiency and when IgG replacement therapy and antibiotic prophylaxis were added a good infectious control was obtained. Next generation sequencing analysis has revealed a novel heterozygous VUS in the IKBKB gene (c.1465A > G; p.Ser489Gly). Functional analysis has shown a reduced capacity of B lymphocytes and CD4 positive T cells in inducing IκBα degradation, with negative impact on NF-kB pathway. Due to recurrent infections attributed to a common condition in childhood and to an exclusive autoimmunity-centered approach in adulthood, both diagnosis and suitable treatment strategies have suffered a significant delay. To reduce the diagnostic delay, pediatricians, general practitioners and specialists should be aware of IEI and the challenges to differentiate them from SID. Furthermore, genetic characterization and functional analysis may contribute to a personalized approach, in a perspective of targeted or semi-targeted therapy.

show abstract

Low Prevalence of Severe Underlying Pathology in Children With Recurrent Respiratory Tract Infections

Cited by 2 publications

References 10 publications

Using targeted second-generation sequencing technique to guide clinical diagnosis and the effect of medication on the therapeutic effect and prognosis of respiratory tract infection in children: An observational study

Using targeted second-generation sequencing technique to guide clinical diagnosis and the effect of medication on the therapeutic effect and prognosis of respiratory tract infection in children: An observational study

Case Report: Crossing a rugged road in a primary immune regulatory disorder

Contact Info

Product

Resources

About