Low Prevalence of<i>Helicobacter Pylori</i>Infection in Canadian Children: A Cross-Sectional Analysis

Segal, Idit; Otley, Anthony; Issenman, Robert M.; Armstrong, David; Espinosa, V.; Cawdron, Ruth; Morshed, Muhammad; Jacobson, Kevan

doi:10.1155/2008/410176

Cited by 25 publications

(19 citation statements)

References 30 publications

(39 reference statements)

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“…In contrast, lower rates of H. pylori exposure have been reported (5?5-7?1 %) for American and Canadian children (19,46) . We found no association between ID and H. pylori exposure among Inuit preschoolers.…”

Section: Discussionmentioning

confidence: 90%

Low prevalence of iron-deficiency anaemia among Inuit preschool children: Nunavut Inuit Child Health Survey, 2007–2008

Pacey

Weiler

Egeland

2010

Public Health Nutr.

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Objective: To report the prevalence rates and correlates for anaemia, iron deficiency (ID) and iron-deficiency anaemia (IDA) among Inuit preschool-aged children. Design: A cross-sectional study assessed iron intake, demographic information, medical history, anthropometrics, Hb, ferritin, C-reactive protein and antibodies to Helicobacter pylori. Setting: Sixteen selected Inuit communities in Nunavut Territory, Canada. Subjects: Inuit (n 388) aged 3-5 years randomly recruited from communities. Results: Anaemia (3-4 years: Hb , 110 g/l; 5 years: Hb , 115 g/l) was prevalent in 16?8 % of children. The prevalence of ID (ferritin , 12 mg/l) was 18?0 % and that of IDA was 5?4 %. When ID was defined as ferritin ,10 mg/l, 10?8 % of children were iron deficient and 3?3 % had IDA. In multiple logistic regression, boys were more likely to be iron deficient (OR 5 2?28, 95 % CI 1?17, 8?25), but no other risk factor emerged for ID. Three-to 4-year-olds were less likely than 5-year-olds to have anaemia from causes other than ID (OR 5 0?11, 95 % CI 0?08, 0?58). Anaemia from other causes was more common among children residing in crowded homes (OR 5 2?30, 95 % CI 1?37, 12?31) and those treated for past-year ear infection (OR 5 1?35, 95 % CI 1?05, 7?21). Conclusions: The low prevalence of ID and IDA is encouraging, but efforts are still needed to reduce rates as they continue to be higher than general population rates. Household crowding and infections may contribute to anaemia and warrant further research.

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Section: Discussionmentioning

confidence: 90%

Low prevalence of iron-deficiency anaemia among Inuit preschool children: Nunavut Inuit Child Health Survey, 2007–2008

Pacey

Weiler

Egeland

2010

Public Health Nutr.

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“…Acquisition of H. pylori infection mainly occurs in children . The prevalence of infection in children varies between 4.9% and 73.3% worldwide depending on different countries, target population, range of ages, years of specimen collection, sample size and detection methods used in the studies . Infection prevention at an earlier age including childhood may reduce the overall infection rate and the incidences of gastric diseases .…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11] The prevalence of infection in children varies between 4.9% and 73.3% worldwide depending on different countries, target population, range of ages, years of specimen collection, sample size and detection methods used in the studies. [12][13][14][15][16] Infection prevention at an earlier age including childhood may reduce the overall infection rate and the incidences of gastric diseases. [17][18][19][20][21][22][23][24] In China, the infection rate is 29.2-53.2% among symptomatic children in hospitals.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors ofHelicobacter pyloriinfection in asymptomatic Chinese children: a prospective, cross-sectional, population-based study

Ding

Zhao

Gong

et al. 2015

Aliment Pharmacol Ther

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Summary Background Limited research has been published on current Helicobacter pylori infection rate in asymptomatic children in China. Aim To assess current Helicobacter pylori infection rate, distribution characteristics and risk factors in Chinese asymptomatic children. Methods A prospective, cross‐sectional, population‐based study was performed from 2009 to 2011 in three cities of China. Helicobacter pylori infection was diagnosed by a stool antigen test. Multi‐stage cluster random sampling was used to select asymptomatic children including neonates. Socioeconomic details were obtained through a standardised questionnaire. Results Among total of 3491 children (0–18 years), the global infection rate was 6.8% and there were no significant differences between genders. Age specific infection rate between regions was significantly different (P < 0.05). The infection rate significantly increased with age (P for trend <0.01). It was low during the newborn (0.6%) to preschool period and was significantly increased in high school students (13.5%) (P < 0.01). Multivariable regression indicated that hand sanitisation, individually served meals, higher education level of mother, above average living space and residence in urban areas were significantly protective against infection (OR 0.749, 0.698, 0.720, 0.838 and 0.770 respectively). Conversely, consuming meals in unsanitised conditions, sharing towels, receiving pre‐chewed food from the mother, artificial feeding and family history of gastrointestinal disease were significantly associated with the risk of infection (OR 1.200, 1.965, 2.002, 1.071 and 2.093 respectively). Conclusions Helicobacter pylori infection rate increases with age in Chinese asymptomatic children and is common after 10 years of age. The rate of infection is related to socioeconomic status.

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“…Helicobacter pylori ( H. pylori ) infection can lead to gastric ulcer, gastritis, gastric cancer, and mucosa‐associated lymphoid tumors (MALT) [1]. The patients were usually infected with H. pylori during their childhood [2], and the H. pylori infectious prevalence in children is 7.1–73.3% worldwide [3,4] and 25.6% in Beijing, China [5].…”

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confidence: 99%

Primary Antibiotic Resistance of Helicobacter pylori Isolated from Beijing Children

Liu

Xiao-min

et al. 2011

Helicobacter

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The high prevalence of primary antibiotic resistance was out of expectation in H. pylori strains isolated from the children in Beijing. Antibiotic susceptibility should be made clear before the antibiotic was used in the anti-H. pylori therapy in this population. The A2143G was the most populated mutation in macrolide-resistant strains, and Asn87 and Asp91 of GyrA were the most common mutation points in quinolone resistance strains.

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Low Prevalence ofHelicobacter PyloriInfection in Canadian Children: A Cross-Sectional Analysis

Abstract: H pylori infection rates in Canadian children with upper GI symptoms are low, and are lower than those reported for other developed countries. Further studies are required in Canada to determine the prevalence in the general population and specifically in the populations at risk.

Cited by 25 publications

References 30 publications

Low prevalence of iron-deficiency anaemia among Inuit preschool children: Nunavut Inuit Child Health Survey, 2007–2008

Low prevalence of iron-deficiency anaemia among Inuit preschool children: Nunavut Inuit Child Health Survey, 2007–2008

Prevalence and risk factors ofHelicobacter pyloriinfection in asymptomatic Chinese children: a prospective, cross-sectional, population-based study

Primary Antibiotic Resistance of Helicobacter pylori Isolated from Beijing Children

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