Low prevalence of hepatitis E infection among pregnant women in Madrid, Spain

Lindemann, María Luisa Mateos; Gabilondo, Gustavo; Romero, Beatriz; Maza, Oihane Martín S. de la; Pérez‐Gracia, María Teresa

doi:10.1002/jmv.21840

Cited by 52 publications

(36 citation statements)

References 12 publications

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“…The rate of 0.4% found among the pregnant women is in agreement with the rates of 0.5%, 0.6%, and 0.67% reported among pregnant women in different regions of the world including Africa [42][43][44]. Our finding, though higher than 0% rate reported in a similar cohort in France [45], is lower than rates ranging from 2.6% to 33% recorded by several authors in a similar cohort in different regions of the world [46][47][48][49][50].…”

Section: Discussionsupporting

confidence: 90%

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Ijeoma

Faleye

Bakarey

et al. 2017

Preprint

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Hepatitis E virus (HEV) remains a major public health concern in resource limited regions of the world. Yet data reporting is suboptimal and surveillance system is inadequate. In Nigeria, there is dearth of information on prevalence of acute HEV infection. This study was therefore designed to describe acute HEV infection among antenatal clinic attendees and community dwellers from two geographical regions in Nigeria. Seven hundred and fifty plasma samples were tested for HEV IgM by Enzyme Linked Immunosorbent Assay (ELISA) technique. The tested samples were randomly selected from a pool of 1,115 blood specimens previously collected for viral hepatitis studies among selected populations (pregnant women, 272; Oyo community dwellers, 438; Anambra community dwellers, 405) between September 2012 and August 2013. One (0.4%) pregnant woman in her 3rd trimester had detectable HEV IgM, while community dwellers from the two study locations had zero prevalence rates of HEV IgM. Detection of HEV IgM in a pregnant woman, especially in her 3rd trimester, is of clinical and epidemiological significance. The need therefore exists for establishment of a robust HEV surveillance system in Nigeria and especially amidst the pregnant population in a bid to improve maternal and child health.

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Section: Discussionsupporting

confidence: 90%

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Ijeoma

Faleye

Bakarey

et al. 2017

Preprint

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“…Genotype 3 of the HEV is characteristic in non-endemic countries and it is the only one isolated so far in autochthonous cases in our country [17,18]. It has been confirmed that the prevalence of HEV infection has not increased in Spain in recent years regardless of the frequent travelling and immigration [4]. This may be due to the good health-care structure in our country.…”

Section: Discussionsupporting

confidence: 62%

“…It has been proved that HEV circulates in Spain [2] and the limited incidence of clinical manifestations is due to good hygienic conditions and an appropriate health-care structure. The prevalence of specific IgG type antibodies (anti-HEV IgG) in Spain varies depending on the type of population being studied; thus, 0.6% has been detected in individuals with no risk factors [3], 3.6% in pregnant women [4], 18.6% in pig farm workers [5], and 10.11% in patients infected with HIV [6,7]. Other characteristics of the epidemiology in industrialized countries are that it affects older people, predominantly men and that the transmission route is generally unknown [8].…”

Section: Introductionmentioning

confidence: 99%

Acute, Chronic and Fulminant Hepatitis E: Ten Years of Experience (2004-2013)

Pérez‐Gracia¹

2014

Int J Gastroenterol Disord Ther

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The hepatitis E virus (HEV) is the main cause of acute epidemic hepatitis in developing countries and it is estimated that approximately one third of the world's population has been infected with this virus. The aim of this study is to describe the most important clinical manifestations and epidemiological aspects in 62 hepatitis E cases treated in Madrid (Spain) during a 10-year period (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013).Fifty-five patients, six patients and one patient with acute, fulminant and chronic hepatitis E, respectively, have been studied over a period of 10 years. Sixty-two individuals (33 male and 10 female) were treated between 2004 and 2013 in the Hospital Ramón y Cajal (Madrid, Spain). The diagnosis was performed by the detection of IgG and IgM anti-HEV and HEV RNA in serum samples. Acute hepatitis E was defined by the presence of IgM anti-HEV and/or HEV RNA in serum and chronic hepatitis E if the RNA was detectable more than 6 months. Fulminant hepatitis E was diagnosed if encephalopathy was observed in addition to IgM anti-HEV and/or RNA HEV in serum. The median age was 46.67 and 49.6 years in acute hepatitis E and fulminant hepatitis E, respectively. The risk factors recorded were travel to endemic areas in 14 patients, 4 were in contact with animals, 5 suffered from hepatic steatosis due to alcohol consumption, 3 consumed uncontrolled foods and 2 used to drink water from streams. HEV is the cause of acute self-limited hepatitis although 50% of the studied cases had to be hospitalized. However a small number of patients, 4.8% had fulminant hepatitis requiring hepatic transplant. Chronic hepatitis E is very infrequent in immunocompetent individuals. The increase in incidence of hepatitis E is due to better diagnostic tests in these recent years.

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“…obejmowały grupę osób z dysfunkcją wątroby lub hospitalizowanych z powodu współistniejących chorób zakaźnych, w tym nosicieli wirusa HIV, obecność swoistych przeciwciał anty-HEV odnotowano u 15,9% badanych (5). Infekcje HEV u kobiet ciężarnych na terenie Europy dotyczą 3,5-5,4% pacjentek i są one na ogół bezobjawowe (6,36). Natomiast szczególnie wysoką śmiertelność ciężarnych (20-45%) obserwuje się w Afryce i Azji, gdzie infekcje utrzymują się endemicznie (3,23).Uważa się, że tylko w tych regionach z powodu wirusowego zapalenia wątroby typu E, dochodzi do 70 000 zgonów i 3000 poronień (55).…”

Section: Replikacja Wirusa W Komórceunclassified