2011
DOI: 10.1590/s1806-83242011005000016
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Low prevalence of gingival overgrowth associated to new imunossupressive protocols with cyclosporin

Abstract: Gingival overgrowth (GO) is a frequent finding in patients treated with cyclosporine (CsA). This study investigated the prevalence and severity of GO in patients who received kidney transplant and CsA therapy, as well as associations with pharmacological and clinical factors. This cross-sectional study included 63 kidney transplant recipients who were treated with CsA in a university hospital. Demographic, pharmacological, and periodontal data were collected. The primary variable was GO. Independent sample t-a… Show more

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Cited by 6 publications
(6 citation statements)
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“…Other risk factors/indicators, including psychosocial factors , metabolic syndrome , osteoporosis/osteopenia , arthritis , use of cyclosporine and alcohol consumption , have also been investigated in Latin American studies, with mixed results obtained.…”
Section: Risk Factors For Chronic Periodontitismentioning
confidence: 99%
“…Other risk factors/indicators, including psychosocial factors , metabolic syndrome , osteoporosis/osteopenia , arthritis , use of cyclosporine and alcohol consumption , have also been investigated in Latin American studies, with mixed results obtained.…”
Section: Risk Factors For Chronic Periodontitismentioning
confidence: 99%
“…[19] However, cyclosporin may have damaging side effects, such as nephrotoxicity, hepatotoxicity, hypertension, and gingival overgrowth. [29] The first time gingival overgrowth with cyclosporin therapy was described in the dental literature in 1983 by both Rateitschak-Plüss et al ., and Wysocki et al . [5] Recently, Greenberg et al .,[30] studied a sample of 115 patients that underwent kidney transplants and found a gingival overgrowth prevalence of 53% among those who were treated with cyclosporin.…”
Section: Drugs Which Cause Gingival Overgrowthmentioning
confidence: 99%
“…Por el contrario, el agrandamiento gingival inducido por inmunosupresores como las ciclosporinas, altamente utilizadas en casos de trasplantes de órganos, tiene una prevalencia de 40%. Se ha encontrado que el efecto de este fármaco depende de la dosis que ingiere el paciente, a menor dosis, menor efecto (7) . La fenitoína, uno de los fármacos más comúnmente utilizado para el tratamiento de pacientes epilépticos debido a su bajo costo y familiaridad, dentro de este grupo de medicamentos es el más…”
Section: Discussionunclassified
“…Dentro de los grupos farmacológicos más asociados al AGFI se encuentran los antihipertensivos de tipo bloqueadores de canales de calcio (6) , inmunosupresores de tipo ciclosporina o azatioprina (7) y entre los anticonvulsivantes principalmente la fenitoína (8) . Una vez identificado el agente asociado al AGFI debe evaluarse la posibilidad de disminución de la dosis empleada o el reemplazo de la medicación de acuerdo a las necesidades y beneficios del paciente; sin embargo, al tratarse de medicamentos para enfermedades de carácter crónico, ésta estrategia se encuentra limitada y puede ocurrir que incluso después de disminuir su dosis se mantenga el agrandamiento gingival y se requiera complementar con medidas de higiene oral adecuadas, iniciar con una fase higiénica exhaustiva para lograr una disminución de la colonización bacteriana y del edema tisular previo a la realización de intervenciones quirúrgicas como gingivectomía del sitio comprometido (8) .…”
Section: Introductionunclassified