Low Prevalence of Chronic Hepatitis C, but High Prevalence of Elevated Aminotransferases in a Cohort of 2026 Patients Referred for Orthopaedic Surgery in the Eastern Part of Germany

Kaiser, Thorsten; Löbstein, Sebastian; Brand, Floris F. van den; Wojan, Magdalena; Stölzel, Ulrich; Liebert, UG; Mössner, Joachim; Hl, Tillmann

doi:10.1055/s-2005-858876

Cited by 18 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This observation matched with the lower frequency of reported patients to the German health authorities for reportable diseases, the Robert Koch Institute (RKI) [2], and a recently published survey on HCV-infected patients from various regions within Germany [3]. However, low awareness could account for low diagnosis rates; therefore, the latter two studies only indirectly confirmed our initial observation [1].…”

Section: Introductionsupporting

confidence: 92%

“…In an earlier study, we evaluated 2026 patients from East German orthopaedic surgeries, and recorded a 0.15% prevalence rate of HCV-RNA positivity [1]. This observation matched with the lower frequency of reported patients to the German health authorities for reportable diseases, the Robert Koch Institute (RKI) [2], and a recently published survey on HCV-infected patients from various regions within Germany [3].…”

Section: Introductionmentioning

confidence: 89%

See 1 more Smart Citation

Autologous blood donor screening indicated a lower prevalence of viral hepatitis in East vs West Germany: epidemiological benefit from established health resources

Luz

Mengelkamp²,

Moog

et al. 2009

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Prevalence data concerning viral hepatitis and human immunodeficiency virus (HIV) in the general population are usually scarce. We aimed for a large cohort representative of the general population that required little funding. Autologous blood donors are relatively representative of the general population, and are tested for viral hepatitis and HIV in many countries. However, frequently these data are not captured for epidemiologic purposes. We analysed data from well over 35,000 autologous blood donors as recorded in 21 different transfusion centres for anti-hepatitis C virus (HCV), HBsAg and anti-HIV, as well as TPHA if available. We found a lower prevalence of hepatitis B virus and HCV in East vs West Germany, 0.2%vs 0.32% and 0.16%vs 0.32% respectively, which confirms earlier data in smaller cohorts, thus supporting the value of our approach. HIV was too rare to disclose significant differences, 0.01%vs 0.02%. TPHA was higher in East (0.34%) vs West Germany (0.29%) without significant differences. HCV was more frequent in women vs men. Transfusion institutes managing autologous blood donations should be used as a resource for epidemiological data relating to viral hepatitis and HIV, if such testing is performed routinely. This approach generates data relating to the general population with special emphasis on undiagnosed cases.

show abstract

Section: Introductionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 89%

Autologous blood donor screening indicated a lower prevalence of viral hepatitis in East vs West Germany: epidemiological benefit from established health resources

Luz

Mengelkamp²,

Moog

et al. 2009

Journal of Viral Hepatitis

View full text Add to dashboard Cite

show abstract

“…Through a detailed review of published literature and the analysis of subpopulations, an anti‐HCV prevalence estimate of 0.5% (0.3–0.9%), corresponding to 410 000 (246 000–738 000) anti‐HCV infections, was estimated for 2012 (Table ) . A national study conducted in 2011, the German Health Interview and Examination Survey for Adults (DEGS1), estimated the anti‐HCV prevalence to be 0.3% (0.1–0.5%) .…”

Section: Resultsmentioning

confidence: 99%

Historical epidemiology of hepatitis C virus (HCV) in selected countries

Bruggmann

Berg

Øvrehus

et al. 2014

Journal of Viral Hepatitis

238

192

View full text Add to dashboard Cite

SUMMARY. Chronic infection with hepatitis C virus (HCV) is a leading indicator for liver disease. New treatment options are becoming available, and there is a need to characterize the epidemiology and disease burden of HCV. Data for prevalence, viremia, genotype, diagnosis and treatment were obtained through literature searches and expert consensus for 16 countries. For some countries, data from centralized registries were used to estimate diagnosis and treatment rates. Data for the number of liver transplants and the proportion attributable to HCV were obtained from centralized databases. Viremic prevalence estimates varied widely between countries, ranging from 0.3% in Austria, England and Germany to 8.5% in Egypt. The largest viremic populations were in Egypt, with 6 358 000 cases in 2008 and Brazil with 2 106 000 cases in 2007. The age distribution of cases differed between countries. In most countries, prevalence rates were higher among males, reflecting higher rates of injection drug use. Diagnosis, treatment and transplant levels also differed considerably between countries. Reliable estimates characterizing HCV-infected populations are critical for addressing HCV-related morbidity and mortality. There is a need to quantify the burden of chronic HCV infection at the national level.

show abstract

“…Die Prävalenz der Hepatitis C weist in Deutschland deutliche regionale Unterschiede auf, z. B. geringere Häufigkeiten in den neuen Bundesländern, die mit einem zu Zeiten der DDR gegenüber Westdeutschland niedrigeren i. v. Drogenkonsum zusammenhän-gen kçnnten [9]. Darüber hinaus weicht die Prävalenz der HCVInfektion in einzelnen Personengruppen deutlich von der Allgemeinbevçlkerung ab.…”

unclassified

Epidemiologie der chronischen Hepatitis C in Deutschland - Eine Analyse von 10 326 Hepatitis-C-Virus-Infizierten aus Schwerpunktpraxen und -ambulanzen

et al. 2008

View full text Add to dashboard Cite

Little is known about the epidemiology of chronic hepatitis C (CHC) in Germany and especially about the importance of transmission, duration of infection, genotypes, symptoms and quality of life of the patients. The current study prospectively evaluates epidemiological and clinical data of patients infected with the hepatitis C virus (HCV). Using online data entry, various characteristics of 10,326 untreated patients with CHC were documented from March 2003 until May 2006 in 352 centres all over Germany. Mean age of patients was 43.4 years. Patients infected by i.v. drug abuse were considerably younger (36.5 years) than the remaining patients (49.2 years). As indicated by their native language, 64.4% of the patients came from Germany and 19.2% from Russia. 61.7% were infected with genotype 1 and 34.9% with genotype 2 or 3. 45.5% of the patients had been infected by i.v. drug abuse. In at least 5.4% of the patients liver cirrhosis had been proved by biopsy. 63.5% of the patients felt an impairment of quality of life caused by CHC. In many patients infected with hepatitis C socio-economic issues are existent. This is reflected, i.e., in very high rates of unemployment in special subpopulations. Coinfections with hepatitis B and HIV occurred in 1.5% and 4.7%, respectively. Nearly 80% of patients were managed near their homes. The data of the 10 326 patients represent about 2% of all German patients with CHC. This database is up to now the largest of its kind and gives a representative insight into the epidemiological situation of CHC in Germany.

show abstract

Low Prevalence of Chronic Hepatitis C, but High Prevalence of Elevated Aminotransferases in a Cohort of 2026 Patients Referred for Orthopaedic Surgery in the Eastern Part of Germany

Cited by 18 publications

References 10 publications

Autologous blood donor screening indicated a lower prevalence of viral hepatitis in East vs West Germany: epidemiological benefit from established health resources

Autologous blood donor screening indicated a lower prevalence of viral hepatitis in East vs West Germany: epidemiological benefit from established health resources

Historical epidemiology of hepatitis C virus (HCV) in selected countries

Epidemiologie der chronischen Hepatitis C in Deutschland - Eine Analyse von 10 326 Hepatitis-C-Virus-Infizierten aus Schwerpunktpraxen und -ambulanzen

Contact Info

Product

Resources

About