Low prevalence and assay discordance of “aspirin resistance” in children

Abstract

In this initial prevalence study of a clinically diverse group of pediatric patients, frequencies of AR were assay-dependent; however, the prevalence of true AR is likely low in children (2.3%; 95% CI 0.1-10.7%), in agreement with adult studies. To better define the clinical relevance of AR in children, multicenter, prospective cohort studies are imperative.

Aspirin unresponsiveness predicts thrombosis in high-risk pediatric patients after cardiac surgery

“…Previous studies have suggested that the incidence of true aspirin resistance in children is approximately 2% and that many patients respond to an appropriate increase in aspirin dosing. 4,9 Future studies should determine if dose adjustment, particularly in neonates and pediatric patients greater than 80 kg, improves responsiveness.…”

Aspirin Resistance

“…Six out of 44 were considered aspirin resistant according to at least one laboratory test (5 by PFA-100, 1 by aggregometry, and urinary 11dhTxB2), which leads to the conclusion that, as with adults, the incidence of AR is also assay-dependent in the pediatric population [31]. Table 1 summarizes the main studies investigating AR prevalence in different clinical entities [28, 30, 32–36].…”

Diagnostic Evaluation of Platelet Function Disorders in Neonates and Children: An Update

“…81 Yee et al have recently reported their investigation of aspirin resistance in 44 children using several different assays: platelet aggregation, PFA-100 closure time, and urinary 11-dehydro thromboxane B 2 . 82 Six patients showed evidence of in vitro resistance in one of the assays, but there was poor correlation among the assays, and no clinical correlation was reported. The identification of a clinically relevant assay for children requires further study.…”