2005
DOI: 10.1152/ajpheart.01081.2004
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Low-pressure reperfusion alters mitochondrial permeability transition

Abstract: We hypothesized that low-pressure reperfusion may limit myocardial necrosis and attenuate postischemic contractile dysfunction by inhibiting mitochondrial permeability transition pore (mPTP) opening. Male Wistar rat hearts (n = 36) were perfused according to the Langendorff technique, exposed to 40 min of ischemia, and assigned to one of the following groups: 1) reperfusion with normal pressure (NP = 100 cmH(2)O) or 2) reperfusion with low pressure (LP = 70 cmH(2)O). Creatine kinase release and tetraphenyltetr… Show more

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Cited by 68 publications
(50 citation statements)
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References 33 publications
(34 reference statements)
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“…In contrast to unimpeded reperfusion, IPost is intermittent reperfusion of the acute ischemic myocardium, which has been reported to prevent myocardial reperfusion injury and reduce MI size by 40%-50% (61). It must be appreciated that IPost represents a form of modified reperfusion that was demonstrated in the 1980s to be beneficial in the form of gradual reperfusion (62)(63)(64)(65). Staat et al (66) first applied IPost to the clinical setting of PPCI: immediately after direct stenting, coronary blood reflow was allowed for 60 seconds, following which the angioplasty balloon was inflated upstream of the stent for 60 seconds to occlude coronary blood flow, and this cycle was repeated 4 times in total ( Table 1).…”
Section: Therapeutic Strategies For Reducing Myocardial Reperfusion Imentioning
confidence: 99%
“…In contrast to unimpeded reperfusion, IPost is intermittent reperfusion of the acute ischemic myocardium, which has been reported to prevent myocardial reperfusion injury and reduce MI size by 40%-50% (61). It must be appreciated that IPost represents a form of modified reperfusion that was demonstrated in the 1980s to be beneficial in the form of gradual reperfusion (62)(63)(64)(65). Staat et al (66) first applied IPost to the clinical setting of PPCI: immediately after direct stenting, coronary blood reflow was allowed for 60 seconds, following which the angioplasty balloon was inflated upstream of the stent for 60 seconds to occlude coronary blood flow, and this cycle was repeated 4 times in total ( Table 1).…”
Section: Therapeutic Strategies For Reducing Myocardial Reperfusion Imentioning
confidence: 99%
“…This observation has since been confirmed in several experimental preparations and with different animal species (rats, rabbits and mice), showing that, when applied at the time of reperfusion, postconditioning significantly reduced infarct size with results comparable to preconditioning (Bopassa et al, 2006;Bopassa et al, 2005;Kin et al, 2005;Kin et al, 2004;Tsang et al, 2004).…”
Section: Disease Models and Mechanisms Dmmmentioning
confidence: 78%
“…Postconditioning also significantly reduced the lipid peroxidation in the myocardial area at risk compared with the control group. All those results showed that postconditioning significantly reduced the reperfusion injury phenomenon.This observation has since been confirmed in several experimental preparations and with different animal species (rats, rabbits and mice), showing that, when applied at the time of reperfusion, postconditioning significantly reduced infarct size with results comparable to preconditioning (Bopassa et al, 2006;Bopassa et al, 2005; Kin et al, 2005; Kin et al, 2004;Tsang et al, 2004).At first glance, the underlying mechanisms of cardioprotection seem to be complex and varied. The mechanisms involve activation of the prosurvival kinases phosphoinositide 3-kinase (PI3K)-Akt and endothelial nitric oxide synthase (eNOS) of the reperfusion injury salvage kinase (RISK) pathway (Tsang et al, 2004), interaction with the mPTP (Hausenloy et al, 2002;Bopassa et al, 2005), and activation of the endogenous receptors of adenosine (Kin et al, 2005).…”
mentioning
confidence: 85%
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“…The concept of reperfusion injury remains controversial with several proposed mechanisms, but it is mainly oxygen-derived free radicals and calcium overload that play an important role in the development of left ventricular dysfunction, stunning, reperfusion arrhythmias, vascular damage, and endothelial dysfunction [15]. Various strategy used to reduce ischemic-reperfusion injury include lowering blood pressure during reperfusion, reducing blood flow during reperfusion, but one of the most vigorously researched methods is controlling arterial oxygen tension in order to reduce reperfusion injury [16][17][18]. Maintaining normoxic cardiopulmonary bypass in children with cyanotic congenital heart disease resulted in dramatically reduced levels of conjugated diens, which represents the lipid peroxidation levels of the heart, compared with patients that maintained on hyperoxic cardiopulmonary bypass [19].…”
Section: Discussionmentioning
confidence: 99%