Low pressure plasma treatment of poly(3-hydroxybutyrate): Toward tailored polymer surfaces for tissue engineering scaffolds

Nitschke, Mirko; Schmack, G.; Janke, Andreas; Simon, F.; Pleul, Dieter; Werner, Carsten

doi:10.1002/jbm.1274.abs

Cited by 31 publications

(50 citation statements)

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“…This result is similar to that found by other workers who have investigated ammonia gas plasma treatment of polymer surfaces. 4 The amount of amino groups on the PHBV surface determined by TFBA derivatization of ammonia plasma-treated samples compares well to the findings from the peak fitting of the N 1s peak. Thus, for a 10 W, 20 s sample 21% ( 2% amino groups were found by the N 1s curve fit (see above) and for the TFBA derivatization the same sample yielded 18% ( 2% amino groups.…”

Section: Resultsmentioning

confidence: 98%

Introducing Amine Functionalities on a Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Surface: Comparing the Use of Ammonia Plasma Treatment and Ethylenediamine Aminolysis

et al. 2006

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Amine functionalities were introduced onto the surface of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) films by applying radio frequency ammonia plasma treatment and wet ethylenediamine treatment. The modified surfaces were characterized by X-ray photoelectron spectroscopy (XPS) for chemical composition and Raman microspectroscopy for the spatial distribution of the chemical moieties. The relative amount of amine functionalities introduced onto the PHBV surface was determined by exposing the treated films to the vapor of trifluoromethylbenzaldehyde (TFBA) prior to XPS analysis. The highest amount of amino groups on the PHBV surface could be introduced by use of ammonia plasma at short treatment times of 5 and 10 s, but no effect of plasma power within the range of 2.5-20 W was observed. Ethylenediamine treatment yielded fewer surface amino groups, and in addition an increase in crystallinity as well as degradation of PHBV was evident from Fourier transform infrared spectroscopy. Raman maps showed that the coverage of amino groups on the PHBV surfaces was patchy with large areas having no amine functionalities.

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Section: Resultsmentioning

confidence: 98%

Introducing Amine Functionalities on a Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Surface: Comparing the Use of Ammonia Plasma Treatment and Ethylenediamine Aminolysis

et al. 2006

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“…Increased wettability, mineralization, attachment, and proliferation of bone marrow stromal cell and chondrocytes [66][67][68][69][70][71][72] PHB, PHBHHx O 2 or air -Increased crystallinity, brittleness, biodegradability, and growth of L929 [74][75][76] Plasma treatment PHBV O 2 plasma Ester, carboxyl, carbonyl Increased hydrophilicity, but maintained only 3-4 months; increased roughness and degradation; increased ALP activity of osteoblasts; increased reattachment of D407 cells [79][80][81][82][83][84] PHBV N 2 plasma CN, CN, CONH Increased hydrophilicity, roughness, and attachment of Vero [85][86][87] PHB, PHBV NH 3 plasma Amino, amide Increased hydrophilicity with a long term stability [88,89] PHBV CO 2 plasma Carbonylic, carboxylic Increased hydrophilicity, roughness, and degradation [90] PHO Air plasma (acrylamide) Amide Increased hydrophilicity [91] PHB, PHBV Allylamine, PEG, and ethylenediamine plasma -Increased cellular resistance; decreased crystal growth [92][93][94] [95] PHB, P3HB4HB Ar plasma (acrylic acid) Carboxylic Increased surface polarity, adhesion, and proliferation of NIH 3T3 cell; decreased biodegradability [96,97] PHB, PHBV Perfluorocarbon plasma CF Decreased surface hydrophilicity and biodegradation [98][99][100] γRadiation graft polymerization is an effective and eco nomical treatment for surface modification. Usually, the grafting percentage depended on differences in regularity in the crystalline regions or crystallinity, and rate of radical decay that corresponded well to radical consumption in graft polym erization.…”

Section: Polyacrylamide Poly(acrylic Acid)mentioning

confidence: 99%

Surface Modification of Polyhydroxyalkanoates toward Enhancing Cell Compatibility and Antibacterial Activity

Liu

Zhang

et al. 2017

Macro Materials & Eng

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Biomaterials for in vivo application should induce positive interaction with various histocytes and inhibit bacteria inflection as well. Cells and/or bacteria response to the extracellular environment is therefore the basic principle to design the biomaterials surface in order to induce the specific biomaterial–biological interaction. Polyhydroxyalkanoate (PHAs) are of growing interests because of their natural origin, biodegradability, biocompatibility, and thermoplasticity; however, quite inert and intrinsic hydrophobic characteristics have hindered their extensive usage in medical applications. Surface modification of PHAs tailors the chemistry, wettability, and topography without altering the bulk properties, and introduces specific proteins/peptides and/or antibacterial agents to mediate cell–matrix interactions. This review describes the recent developments on the surface modification of PHAs to construct cell compatible and antibacterial surfaces.

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“…Many approaches have been taken to modify the surface of PHBV to date. For example, surface hydrophobicity and surface chemistry were altered using oxygen plasma treatment (4-7), perfluorohexane plasma (8), allylamine plasma (9), and ammonia plasma (10). In addition, studies investigated gamma irradiation induced graft polymerization of methyl methacrylate and 2-hydroxyethyl methacrylate (11) or acrylic acid (AAc) (12) onto PHBV.…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Membrane by Combining Surface Aminolysis Treatment with Collagen Immobilization

Wang

Cao

2009

Journal of Macromolecular Science, Part A

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Amino groups were introduced onto a poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) surface by applying 1,6-hexanediamine treatment. The effects of aminolysis time and 1,6-hexanediamine concentration on hydrophilicity of the treated PHBV were investigated using contact angle measurement. The occurrence of the aminolysis and the introduction of NH 2 groups were verified by X-ray photoelectron spectroscopy (XPS) and ninhydrin method. By use of the NH 2 groups as active sites, collagen was further immobilized on the aminolyzed PHBV (NH 2 -PHBV) membrane via a cross-linking agent, glutaraldehyde. The increase of nitrogen content and further decrease of water contact angle after immobilization of collagen suggested that the surfaces became more hydrophilic. Mouse bone marrow stromal cells (BMSc) cultured on untreated PHBV and treated PHBV films were evaluated by cell attachment, cell proliferation, and morphological observation under scanning electron microscope (SEM). The order of cytocompatibility is Coll-PHBV > NH 2 -PHBV> PHBV, indicating coll-PHBV was a promising material in future tissue-engineering application.

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Low pressure plasma treatment of poly(3-hydroxybutyrate): Toward tailored polymer surfaces for tissue engineering scaffolds

Cited by 31 publications

References 0 publications

Introducing Amine Functionalities on a Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Surface: Comparing the Use of Ammonia Plasma Treatment and Ethylenediamine Aminolysis

Introducing Amine Functionalities on a Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Surface: Comparing the Use of Ammonia Plasma Treatment and Ethylenediamine Aminolysis

Surface Modification of Polyhydroxyalkanoates toward Enhancing Cell Compatibility and Antibacterial Activity

Surface Modification of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Membrane by Combining Surface Aminolysis Treatment with Collagen Immobilization

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