Low Power Upconverted Near‐IR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release

Viger, Mathieu L.; Grossman, Madeleine; Fomina, Nadezda; Almutairi, Adah

doi:10.1002/adma.201300902

Cited by 107 publications

(92 citation statements)

References 52 publications

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“…Since in our geometry the nanoparticles are not in direct contact with the metal, quenching, which is generally considered the most pressing limitation in using plasmonics resonances for UC enhancement, is of no concern. The UC containing nanocavities as proposed in this Letter could be potentially useful in drug delivery and release at target applications [14]. …”

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confidence: 95%

Engineering upconversion emission spectra using plasmonic nanocavities

Lantigua

Bouzan

et al. 2014

Opt. Lett.

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We show that the upconversion emission spectra of Tm³⁺ and Yb³⁺ codoped β-NaYF₄-NaYF₄ core-shell nanoparticles can be judiciously modified by means of plasmonic nanocavities. Our analysis indicates that more than a 30-fold increase in conversion efficiency to the UV spectral band can be expected by engineering the NIR absorption and the local density of states. The effect of the nanocavity on the resulting radiation patterns is discussed. Our results are exemplified in cylindrical cavity geometries.

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confidence: 95%

Engineering upconversion emission spectra using plasmonic nanocavities

Lantigua

Bouzan

et al. 2014

Opt. Lett.

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“…In recent years, the successful synthesis of colloidally stable solutions of monodisperse upconverting nanoparticles (UCNPs) with diameters on the order and less than 50 nm has opened up new opportunities in this general area [7][8][9]. It is envisioned that such UCNPs may replace dye molecules as diagnostic and therapeutic tools for biological imaging, or can be used in targeted drug delivery [10][11][12]. Unfortunately, the conversion efficiency of UCNPs can be even lower than their bulk counterparts, something that imposes a serious challenge in utilizing these nanoparticles in most settings.…”

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confidence: 99%

Enhanced UV upconversion emission using plasmonic nanocavities

Halawany

Hodaei

et al. 2016

Opt. Express

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Upconversion of near infrared (NIR) into ultraviolet (UV) radiation could lead to a number of applications in bio-imaging, diagnostics and drug delivery. However, for bare nanoparticles, the conversion efficiency is extremely low. In this work, we experimentally demonstrate strongly enhanced upconversion emission from an ensemble of β-NaYF 4 :Gd 3+ /Yb 3+ /Tm 3+ @NaLuF 4 core-shell nanoparticles trapped in judiciously designed plasmonic nanocavities. In doing so, different metal platforms and nanostructures are systematically investigated. Our results indicate that using a cross-shape silver nanocavity, a record high enhancement of 170-fold can be obtained in the UV band centered at a wavelength of 345 nm. The observed upconversion efficiency improvement may be attributed to the increased absorption at NIR, the tailored photonic local density of states, and the light out-coupling characteristics of the cavity. References and links1. F. Auzel, "Upconversion and anti-Stokes processes with f and d ions in solids," Chem. Rev. 104(1), 139-174 (2004). 2. X. Li, F. Zhang, and D. Zhao, "Highly efficient lanthanide upconverting nanomaterials: progresses and challenges," Nano Today 8(6), 643-676 (2013). 3. N. Bloembergen, "Solid state infrared quantum counters," Phys. Rev. Lett. 2(3), 84-85 (1959) . 36. E. M. Purcell, "Spontaneous emission probabilities at radio frequencies," Phys. Rev. 69, 681 (1946). 37.

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“…Later, Almutairi et al [150] and Xing et al [151] applied this strategy to induce the disruption of nanocarriers and subsequent release of coumarin 153 and DOX, respectively. In Almutairi's report, the NIR-induced disruption was achieved by a cascade of cyclization and rearrangement reactions of the polymer chains consisting of o-nitrobenzyl-functionalized cresol monomer.…”

Section: Caging Groupmentioning

confidence: 98%

Upconversion Nanoparticles for Light-Activated Therapy

Zhang¹

2014

Photon Upconversion Nanomaterials

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Light-activated therapy (LAT) has attracted enormous attention over the past decades because light enables noninvasive activation or release of various therapeutic compounds, such as photosensitizers, chemotherapeutic drugs, proteins, and genes with high spatial and temporal resolution. However, most currently used photosensitive compounds in LAT are sensitive to ultraviolet (UV) or visible light which suffers from some limitations such as low tissue penetration and photodamage to living organisms. Upconversion nanoparticles (UCNPs) that can convert near-infrared (NIR) light to visible/UV light have been proven to be effective for LAT in vivo in recent years, owing to the high tissue penetration and minimal photocytotoxicity of NIR light. Furthermore, hydrophilic UCNPs with targeting moieties can transport hydrophobic drugs in biological media and achieve active targeting, thus enhancing the therapeutic efficacy. In this chapter, we review the recent advances in the field of UCNP-based LAT with focus on photodynamic therapy (PDT) and NIR light-triggered release and uncaging.Keywords Light-activated therapy Á Upconversion nanoparticles Á Near-infrared excitation Á Photodynamic therapy Á Photosensitizer Á Light-triggered drug release Á Uncaging IntroductionThe past decades have seen considerable interest and progress in light-activated therapy (LAT), including photodynamic therapy (PDT), chemotherapy, gene therapy, and photothermal therapy (PTT) as light is noninvasive and controllable both spatially and temporally compared to other stimuli such as temperature, pH, ultrasound, and applied magnetic or electric fields [1,2]. Owing to these Zhenzhen Guo and Fan Zhang contributed together to this chapter.© Springer-Verlag Berlin Heidelberg 2015 F. Zhang, Photon Upconversion Nanomaterials, Nanostructure Science and Technology, DOI 10.1007/978-3-662-45597-5_9 285 advantages, this effective therapeutic approach is beneficial to control drug dosing in terms of quantity, location, and time, hence maximizing therapeutic effect while minimizing side effects [3]. However, the excitation of most commonly used photosensitizers for PDT and photoactive molecules for the release of chemotherapeutic drugs and genes relies on high-energy ultraviolet (UV) or visible light irradiation [4,5]. The tissue penetration depth of UV-visible light is shallow because of the scattering and absorption by tissue chromophores [6]. What is worse, the heterocyclic bases of DNA are major UV-absorbing chromophores in the skin. The absorption leads to damage of the DNA, which may result in the generation of tumors [7]. These limitations would greatly hamper their applications in vivo. Compared to UV and visible light, near-infrared (NIR) light has a larger penetration depth, lower levels of the auto-fluorescence , and photodamage effect [8] and is thus better suited for biomedical applications. Therefore, another component that is capable of converting NIR excitation into UV or visible emission should be introduced into current LAT systems in o...

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Low Power Upconverted Near‐IR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release

Cited by 107 publications

References 52 publications

Engineering upconversion emission spectra using plasmonic nanocavities

Engineering upconversion emission spectra using plasmonic nanocavities

Enhanced UV upconversion emission using plasmonic nanocavities

Upconversion Nanoparticles for Light-Activated Therapy

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