Low-power laserthermia for the treatment of small hepatocellular carcinoma

Huang, Guan‐Tarn; Wang, Teh‐Hong; Sheu, Jin‐Chuan; Daikuzono, Norio; Sung, Juei‐Low; Wu, M C; Chen, Ding‐Shinn

doi:10.1016/0277-5379(91)90429-h

Cited by 50 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Determination of the volume of the area to be heated is complex and depends on the laser power, the laser irradiation time and wavelength of light involved, how the energy reaches the tissue, and such tissue factors as optical and thermal properties (22)(23)(24)(25)(26)(27)29,44). Since different types of tissue have different optical characteristics, the choice of a specific laser treatment must be related to the tissue type involved (44).…”

Section: Discussionmentioning

confidence: 99%

“…CT was performed with a helical scanner (HiSpeed Advantage; GE Medical Systems, Milwaukee, Wis). In all patients, triple-phase scans were obtained starting 25,70, and 180 seconds after the powered injection (CT 9000; Liebel-Flarsheim, Cincinnati, Ohio) of a single bolus of a solution of 150 mL of iopromide (Ultravist 370; Schering, Berlin, Germany) in water at a rate of 5 mL/ sec (29).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Laser Thermal Ablation in the Treatment of Small Hepatocellular Carcinoma: Results in 74 Patients

Pacella¹,

Bizzarri²,

Magnolfi³

et al. 2001

Radiology

148

100

View full text Add to dashboard Cite

PURPOSE: To evaluate the safety, local effectiveness, and long-term results of laser\ud thermal ablation (LTA) in the treatment of small hepatocellular carcinoma (HCC).\ud MATERIALS AND METHODS: Ninety-two biopsies proved small HCCs (range,\ud 0.8–4.0 cm) in 74 patients who were treated percutaneously with LTA in an\ud outpatient clinic. A laser at a power of 5.0Wwas coupled with one to four fibers that\ud were advanced through 21-gauge needle(s) for 6–12 minutes. All lesions were\ud evaluated with computed tomography (CT) for changes in size and vascular pattern,\ud recurrence rates, and cumulative survival rates. Patients were examined for complications.\ud RESULTS: No major complications occurred in 117 LTA sessions, with an average of\ud 1.3 sessions per tumor. At 3 months, CT scans showed a nonenhancing area\ud (complete necrosis) in 89 (97%) of 92 lesions. During follow-up (range, 6–66\ud months; mean, 25.3 months), 84 tumors (91%) decreased in size. The local recurrence\ud rates (range, 1–5 years) ranged from 1.6% to 6.0%. Recurrence rates (range,\ud 12–60 months) in other liver segments ranged from 24% to 73%. Cancer-free\ud survival rates (range, 1–4 years) ranged from 73% to 24%. Overall survival rates\ud were 99%, 68%, and 15% at 1, 3, and 5 years, respectively. Twenty-one patients\ud (28%) died.\ud CONCLUSION: LTA is a safe and effective treatment for small HCC

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Laser Thermal Ablation in the Treatment of Small Hepatocellular Carcinoma: Results in 74 Patients

Pacella¹,

Bizzarri²,

Magnolfi³

et al. 2001

Radiology

148

100

View full text Add to dashboard Cite

show abstract

“…Laser irradiation increases the local temperature more rapidly, allowing a shorter time for ablation than RFA [11]. Thermotherapy for HCC and metastatic liver tumors using the Nd:YAG laser had already been attempted in the 1980s [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Clinical application of Nd:YAG laser for the treatment of small hepatocellular carcinoma with new shaped laser probe

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Light is delivered via flexible quartz fibers with a diameter from 300 to 600 μ m. Conventional bare tip fibers provide a near spherical lesion about 15 mm diameter at their ends but have been largely replaced by interstitial fibers, which have flat or cylindrical diffusing tips and are 10–40 mm long, providing a much large ablative area of up to 50 mm [56, 57]. The use of beam splitting devices allows for the use of up to four fibers at once with corresponding increase in ablative volume: multiple fibers must be placed, however, and the devices only work effectively at lower powers [55].…”

Section: General Principles and Techniquesmentioning

confidence: 99%

Laser Ablation for Small Hepatocellular Carcinoma

Pacella

Francica²,

Costanzo

2011

Radiology Research and Practice

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and is increasingly detected at small size (<5 cm) owing to surveillance programmes in high-risk patients. For these cases, curative therapies such as resection, liver transplantation, or percutaneous ablation have been proposed. When surgical options are precluded, image-guided tumor ablation is recommended as the most appropriate therapeutic choice in terms of tumor local control, safety, and improvement in survival. Laser ablation (LA) represents one of currently available loco-ablative techniques: light is delivered via flexible quartz fibers of diameter from 300 to 600 μm inserted into tumor lesion through either fine needles (21g Chiba needles) or large-bore catheters. The thermal destruction of tissue is achieved through conversion of absorbed light (usually infrared) into heat. A range of different imaging modalities have been used to guide percutaneous laser ablation, but ultrasound and magnetic resonance imaging are most widely employed, according to local experience and resource availability. Available clinical data suggest that LA is highly effective in terms of tumoricidal capability with an excellent safety profile; the best results in terms of long-term survival are obtained in early HCC so that LA can be proposed not only in unresectable cases but, not differently from radiofrequency ablation, also as the first-line treatment.

show abstract

Low-power laserthermia for the treatment of small hepatocellular carcinoma

Cited by 50 publications

References 8 publications

Laser Thermal Ablation in the Treatment of Small Hepatocellular Carcinoma: Results in 74 Patients

Laser Thermal Ablation in the Treatment of Small Hepatocellular Carcinoma: Results in 74 Patients

Clinical application of Nd:YAG laser for the treatment of small hepatocellular carcinoma with new shaped laser probe

Laser Ablation for Small Hepatocellular Carcinoma

Contact Info

Product

Resources

About