Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease

Wu, Qian; Rayman, Margaret P.; Lv, Hongjun; Schomburg, Lutz; Cui, Bo; Gao, Chuqi; Chen, Pu; Zhuang, Guihua; Zhang, Zhenan; Peng, Xiaogang; Li, Hua; Zhao, Yang; He, Xinrong; Zeng, Gaoyuan; Qin, Fei; Hou, Peng; Shi, Bingying

doi:10.1210/jc.2015-2222

Cited by 206 publications

(144 citation statements)

References 37 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…low serum Se being associated with thyroid volume and poor echostructure [29], multiple thyroid nodules [30] or goiter risk in children [31]. The importance of Se as potential risk factor for thyroid diseases has just been verified in a very large epidemiological trial involving almost 7,000 subjects from a Se-deficient and less-deficient county in China [32]. Additional studies in this direction are also under way to test this hypothesis in large European patient groups [33].…”

Section: Discussionmentioning

confidence: 99%

Lack of Association between Selenium Status and Disease Severity and Activity in Patients with Graves' Ophthalmopathy

Dehina¹,

Hofmann²,

Behrends³

et al. 2016

Eur Thyroid J

Self Cite

View full text Add to dashboard Cite

Background: Selenium (Se) is of importance for regular functioning of the immune system and thyroid gland, and may have a health effect in mild Graves' ophthalmopathy (GO). Objective: As the Se status declines in inflammation, we analyzed whether GO activity or severity affects the Se status of patients. Methods: Serum Se and selenoprotein P (SePP) concentrations were retrospectively determined in 84 consecutive GO patients before treatment and compared to their clinical activity score (CAS) and severity of eye changes (NOSPECS) status, and to the concentrations of autoantibodies targeting the TSH receptor (TRAK) or the IGF1 receptor (IGF1R-aAB). Results: Serum Se and SePP were linearly associated, indicating a suboptimal Se status of our patients. In comparison to data from other European cohorts, the majority of GO patients had a relatively poor Se status ([Se] ± SD; 70.0 ± 23.8 µg/l), below the threshold needed for full expression of selenoproteins. TRAK were inversely associated with Se concentrations, while IGF1R-aAB titers were not associated with Se. Neither Se nor SePP concentrations differed between GO patients with severe versus mild or active versus inactive disease, or showed significant associations with the CAS or NOSPECS values. Conclusion: GO patients are at risk of a low Se status, yet disease severity or activity does not seem to affect Se or SePP concentrations directly. However, as the retrospective nature of the analysis does not allow conclusions on a potential causative role of Se on Graves' disease or GO risk, these results neither support nor discourage adjuvant Se supplementation attempts.

show abstract

Section: Discussionmentioning

confidence: 99%

Lack of Association between Selenium Status and Disease Severity and Activity in Patients with Graves' Ophthalmopathy

Dehina¹,

Hofmann²,

Behrends³

et al. 2016

Eur Thyroid J

Self Cite

View full text Add to dashboard Cite

show abstract

“…Selenium (Se) deficiency has been associated with a number of diseases [1], including thyroid diseases such as goiter, hypothyroidism, and autoimmune thyroiditis [2]. Se is an essential micronutrient that is incorporated into biologically active selenoproteins as the amino acid selenocysteine [3].…”

mentioning

confidence: 99%

Selenium in the Treatment of Thyroid Diseases: An Element in Search of the Relevant Indications?

Bonnema¹,

Winther²

2016

Eur Thyroid J

View full text Add to dashboard Cite

“…Oxidative stress in particular progressively increases as thyroid dysfunction worsens, and Se deficiency has been associated with increased rates of thyroid disease, especially thyroid autoimmunity and hypothyroidism [31,32]. Therefore, in the present study, we further explored the hypothesis that the antioxidant activity of Se may have an impact on EPC counts, i.e.…”

Section: Discussionmentioning

confidence: 99%

Levothyroxine but Not Selenium Increases Endothelial Progenitor Cell Counts in Patients with Hypothyroidism

Negro

Greco²

2016

Eur Thyroid J

View full text Add to dashboard Cite

Background: Hypothyroidism is a common endocrine disease associated with increased oxidative stress, increased cardiovascular (CV) risk, CV events and endothelial dysfunction. Endothelial progenitor cells (EPCs) are a well-known marker of CV risk. Objective: The aim of this work was to ascertain whether hypothyroidism is associated with lower EPC counts and if treatment with levothyroxine (LT4) or selenium (Se) improves EPC counts compared to placebo. Methods: Hypothyroid patients (n = 100) were randomly divided into five groups to receive placebo (group A), LT4 (group B) or Se at doses of 83 µg (group C), 166 µg (group D) or 249 µg (group E) for 3 months. Each group comprised 20 patients: 10 with ‘mild' hypothyroidism and 10 with ‘severe' hypothyroidism. A healthy control group (group F) with 20 euthyroid subjects was also recruited. Subjects had to be free of CV disease, diabetes and drugs that interfere with EPCs. Anthropometric measurements (height, weight, BMI), blood pressure, fasting lipids and EPC analyses were performed at baseline and after 3 months. Results: EPC counts were significantly lower in hypothyroid patients compared to controls. EPCs increased after 3 months of treatment with LT4, but not with Se at any dosage. CD133+ and CD34+ EPC counts were negatively correlated with thyroid-stimulating hormone (TSH; r² = 0.523, p < 0.01 and r² = 0.517, p < 0.01, respectively) and positively correlated with FT4 (r² = 0.394, p < 0.01 and r² = 0.369, p < 0.01, respectively). TSH and FT4 were the only predictors of EPC counts. Conclusions: Hypothyroidism is associated with low EPC counts. Treatment with LT4, but not Se, can improve EPC counts.

show abstract

Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease

Abstract: Low selenium status is associated with increased risk of thyroid disease. Increased selenium intake may reduce the risk in areas of low selenium intake that exist not only in China but also in many other parts of the world.

Cited by 206 publications

References 37 publications

Lack of Association between Selenium Status and Disease Severity and Activity in Patients with Graves' Ophthalmopathy

Lack of Association between Selenium Status and Disease Severity and Activity in Patients with Graves' Ophthalmopathy

Selenium in the Treatment of Thyroid Diseases: An Element in Search of the Relevant Indications?

Levothyroxine but Not Selenium Increases Endothelial Progenitor Cell Counts in Patients with Hypothyroidism

Contact Info

Product

Resources

About