Low platelet monoamine oxidase activity in Swedish imprisoned criminal offenders

Garpenstrand, Håkan; Longato-Stadler, Eva; Klinteberg, Britt af; Grigorenko, Elena L.; Damberg, Mattias; Oreland, Lars; Hallman, Jarmila

doi:10.1016/s0924-977x(01)00148-1

Cited by 30 publications

(13 citation statements)

References 46 publications

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“…0.001) as compared with the control group, even when smoking was controlled for (p ! 0.01) [20]. This was further supported by the present results with a comparison of the five subgroups with the controls, where all diagnostic groups had lower platelet MAO activity than the controls ( fig.…”

Section: Platelet Mao Activitysupporting

confidence: 89%

“…Of these subjects, 83 were regular smokers, equally distributed over the personality disorder groups, and thus smoking was supposed not to influence group comparisons. Moreover, results from another study on the present study group of criminals indicated that tobacco smoking was not the decisive factor for the difference in platelet MAO activity compared with a control group with similar smoking habits [20].…”

Section: Subjectscontrasting

confidence: 44%

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Personality Traits and Platelet Monoamine Oxidase Activity in a Swedish Male Criminal Population

et al. 2002

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Background: A Swedish male criminal population was grouped into personality disorder subgroups and investigated with regard to personality traits and platelet monoamine oxidase (MAO) activity. The main aim of the study was to examine the possibility of a risk factor combination by having low platelet MAO activity as well as belonging to a certain diagnostic DSM-IV axis I (drug abuse in the present series) and/or II subgroup. Methods: Personality disorders were grouped into clusters according to the cluster system used in DSM-IV axis II. The prisoners were grouped into five subgroups and each subject completed the Karolinska Scales of Personality self-report questionnaire. The comparison group for the personality data comprised 51 non-criminal males from a longitudinal Swedish project. Platelet MAO activity was assessed for the criminals as well as for a control group including 60 non-criminal healthy male Caucasians. For testing the existence of syndromes, a configuration frequency analysis (CFA) was used. Results: The results showed low scores on the socialisation and high scores on the sensation seeking-related traits impulsiveness and monotony avoidance, and the somatic anxiety-related muscular tension in the criminals with any DSM-IV mental disorder, however most markedly in cluster AB and cluster B subjects. In addition, cluster AB subjects had significantly lower platelet MAO activity than controls. Two significant ‘types’ were found among the criminals: one was characterised by low platelet MAO activity, cluster B personality diagnosis as well as drug abuse disorder diagnosis; and the other by a pattern of normal platelet MAO activity, no cluster B personality disorder and no drug abuse disorder diagnosis. Conclusion: The aggregation of certain risk factors in the same individual has been shown to contribute to the development of criminal behaviour.

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Section: Platelet Mao Activitysupporting

confidence: 89%

Section: Subjectscontrasting

confidence: 44%

Personality Traits and Platelet Monoamine Oxidase Activity in a Swedish Male Criminal Population

et al. 2002

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“…Several studies have reported associations with aggressiveness [11,14,15] and violence and aggression in crime [28,29] , but not all studies have found such associations [30] . In a study by Alm et al [31] , low platelet MAO-B activity stood out as one of two independent but synergistic predictors of continuation of criminal activity into adulthood together with psychopathic personality traits according to the Revised Psychopathy Checklist (PCL-R) [32] .…”

Section: Introductionmentioning

confidence: 99%

Platelet Monoamine Oxidase B Activity Did Not Predict Destructive Personality Traits or Violent Recidivism: A Prospective Study in Male Forensic Psychiatric Examinees

Gustavson

Wass²,

Månsson³

et al. 2010

Neuropsychobiology

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Aims: This prospective study was designed to replicate previous findings of an association between the platelet monoamine oxidase B (MAO-B) activity and factors of relevance for criminal behaviour in a well-documented clinical study population. Methods: Subjects (n = 77, aged 17–76 years, median 30 years) were recruited among consecutive perpetrators of severe interpersonal violent and/or sexual crimes referred to forensic psychiatric investigation. Participants were extensively investigated by structured psychiatric, psychological and social workups, including state-of-the-art rating instruments and official records, and with laboratory tests including venous blood sampling for determination of MAO-B activity. A subset of 36 individuals had lumbar punctures to measure cerebrospinal fluid concentrations of monoamine neurotransmitter metabolites. Results: Platelet MAO-B activity did not show any significant correlation with assessments of childhood behavioural disorders, substance abuse, or psychosocial adversity, nor with any crime-related factors, such as scores on the Life History of Aggression Scale, the Psychopathy Checklist or recidivistic violent crime. No significant correlation was found between MAO-B and any of the monoamine metabolites. Analyses in subgroups of smokers/non-smokers did not change this overall result. Conclusions: The findings of the present study did not support the use of MAO-B as a biological marker for aggression-related personality traits or as a predictor for violent recidivism among violent offenders.

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“…MAO-A uVNTR activity is an interesting issue to investigate in behavioral disorders associated with abnormalities in monoaminergic neurotransmission. In diverse clinical, forensic and non-patient populations, decreased levels of platelet MAO activity have been shown to be correlated with personality traits such as impulsiveness and sensation seeking [29][30][31] . The results are consistent with previous reports about platelet MAO activity and aggressiveness, impulsivity and anger-related personality traits.…”

Section: Discussionmentioning

confidence: 99%

Association between Monoamine Oxidase A Polymorphisms and Anger-Related Personality Traits in Korean Women

Yang¹,

Lee

Ryu

et al. 2007

Neuropsychobiology

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It has been suggested that polymorphisms in the monoamine oxidase A (MAO-A) gene are associated with aggressive and impulsive behaviors. In the present study, we investigated the association of the MAO-A variable number of tandem repeat polymorphism in the promoter region (MAO-A uVNTR) with anger-related personality traits. Specifically, MAO-A uVNTR polymorphisms were examined for associations with the State-Trait Anger Expression Inventory (STAXI) scores in 211 normal Korean women. All subjects were assessed using the STAXI and genotyped for MAO-A uVNTR status. The scores on the STAXI subscales differed significantly among the MAO-A uVNTR polymorphism genotypes in terms of anger expression-out (AX-Out) scores. Post hoc comparisons revealed significant differences between the 3/3 and 4/4, and between 3/4 and 4/4 polymorphisms. However, no significant difference was observed in other STAXI subscale scores among these genotypes. Subjects with the high-activity MAO-A uVNTR had significantly higher AX-Out scores than subjects with other genotypes. MAO-A uVNTR polymorphisms may contribute in part to the expression of anger. These findings support the hypothesis that this polymorphism in the MAO-A gene may be associated with anger-related personality traits in Korean women.

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Low platelet monoamine oxidase activity in Swedish imprisoned criminal offenders

Cited by 30 publications

References 46 publications

Personality Traits and Platelet Monoamine Oxidase Activity in a Swedish Male Criminal Population

Personality Traits and Platelet Monoamine Oxidase Activity in a Swedish Male Criminal Population

Platelet Monoamine Oxidase B Activity Did Not Predict Destructive Personality Traits or Violent Recidivism: A Prospective Study in Male Forensic Psychiatric Examinees

Association between Monoamine Oxidase A Polymorphisms and Anger-Related Personality Traits in Korean Women

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