Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants

Wu, Brian T.; Innis, Sheila M.; Mulder, Kelly A; Dyer, Roger; King, D. J.

doi:10.3945/ajcn.113.060269

Cited by 33 publications

(28 citation statements)

References 47 publications

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“…In our prevalence subreview, 14 of the 57 studies reported homocysteine concentrations (19,29,53,54,62,66,75,84,87,88,92,96,97,99). Although a detailed discussion of the associations between vitamin B-12 Characteristics and results from studies that describe an association between maternal or cord blood vitamin B-12 and birth outcomes by correlation/ regression analysis are shown (n = 10 studies, 19 results).…”

Section: Vitamin B-12 Insufficiency and Bwmentioning

confidence: 99%

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Sukumar

Rafnsson

Kandala

et al. 2016

The American Journal of Clinical Nutrition

102

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Background: Vitamin B-12 and folate are micronutrients essential for normal embryogenesis. Vitamin B-12 insufficiency in pregnancy is high in certain parts of the world, such as India, and although this has been linked to low birth weight (LBW) in these populations, the relation between vitamin B-12 and birth weight (BW) elsewhere is unknown. Objectives: We performed a systematic review to assess 1) the worldwide prevalence of vitamin B-12 insufficiency in pregnancy and 2) its association with BW. Design: A search of 5 electronic databases was performed to identify eligible articles. Random-effects meta-analysis was conducted according to geographic regions and pregnancy trimesters for the prevalence subreview and by categorical measures of BW. Results: A total of 57 and 23 articles were included for the prevalence and BW subreviews, respectively. The pooled estimates of vitamin B-12 insufficiency were 21%, 19%, and 29% in the first, second, and third trimesters, respectively, with high rates for the Indian subcontinent and the Eastern Mediterranean. The large heterogeneity between studies was partially addressed by creating a standardized score for each study (mean vitamin B-12 insufficiency O cutoff value), which internally corrected for geographic region, trimester, and assay type. Twelve of the 13 longitudinal studies included showed a decrease in mean or median vitamin B-12 across trimesters. Pooled analysis showed nonsignificantly lower maternal vitamin B-12 concentrations in LBW than in normal-BW infants and higher odds of LBW with lower vitamin B-12 values (adjusted OR: 1.70; 95% CI: 1.16, 2.50), but studies from India largely contributed to the latter. Conclusions: Our review indicates that vitamin B-12 insufficiency during pregnancy is common even in nonvegetarian populations and that concentrations of vitamin B-12 decrease from the first to the third trimester. There is no consistent association between vitamin B-12 insufficiency and LBW. However, given the long-term risks of LBW, this observation warrants further cohort studies and randomized controlled trials.Am J Clin Nutr 2016;103:1232-51.

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Section: Vitamin B-12 Insufficiency and Bwmentioning

confidence: 99%

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Sukumar

Rafnsson

Kandala

et al. 2016

The American Journal of Clinical Nutrition

102

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“…Currently, there is some understanding for benefits of folic acid supplementation in schizophrenic patients. Moreover, the efficacy of supplementing a nutrient antioxidant such as folic acid in improving the enzymatic defense system demonstrates its potential application as a prophylactic treatment (Wu et al, 2013). New research in both humans and animals is needed to establish precise protocols, better costs, and thus identify patients who will actually benefit from this supplementation (Roffman et al, 2013b).…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Effect of folic acid on oxidative stress and behavioral changes in the animal model of schizophrenia induced by ketamine

Zugno

Canever

Heylmann

et al. 2016

Journal of Psychiatric Research

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“…A compromised vitamin B12 status has been reported in a number of studies of lactovegetarian subjects (Antony AC, 2003, Pawlak et al, 2014). Plasma choline, betaine and dimethylglycine were lower at 36 weeks gestation in women who were folate replete but had low plasma B12 levels (Wu et al, 2013). Since dietary choline can be a source of methyl groups for one carbon metabolism, the authors suggested that the B12 and choline interaction could be a determinant of infant growth.…”

Section: One Carbon Metabolism and The Health Of The Mother Fetusmentioning

confidence: 99%

One carbon metabolism in pregnancy: Impact on maternal, fetal and neonatal health

Kalhan

2016

Molecular and Cellular Endocrinology

102

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One carbon metabolism or methyl transfer, a crucial component of metabolism in all cells and tissues, supports the critical function of synthesis of purines, thymidylate and methylation via multiple methyl transferases driven by the ubiquitous methyl donor s-adenosylmethionine. Serine is the primary methyl donor to the one carbon pool. Intracellular folates and methionine metabolism are the critical components of one carbon transfer. Methionine metabolism requires vitamin B12, B6 as cofactors and is modulated by endocrine signals and is responsive to nutrient intake. Perturbations in one carbon transfer can have profound effects on cell proliferation, growth and function. Epidemiological studies in humans and experimental model have established a strong relationship between impaired fetal growth and the immediate and long term consequences to the health of the offspring. It is speculated that during development, maternal environmental and nutrient influences by their effects on one carbon transfer can impact the health of the mother, impair growth and reprogram metabolism of the fetus, and cause long term morbidity in the offspring. The potential for such effects is underscored by the unique responses in methionine metabolism in the human mother during pregnancy, the absence of transsulfuration activity in the fetus, ontogeny of methionine metabolism in the placenta and the unique metabolism of serine and glycine in the fetus. Dietary protein restriction in animals and marginal protein intake in humans causes characteristic changes in one carbon metabolism. The impact of perturbations in one carbon metabolism on the health of the mother during pregnancy, on fetal growth and the neonate are discussed and their possible mechanism explored.

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Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants

Abstract: This study shows that maternal vitamin B-12 status is related to choline status in late gestation in a folate-replete population and may be a determinant of infant growth even in the absence of undernutrition.

Cited by 33 publications

References 47 publications

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Effect of folic acid on oxidative stress and behavioral changes in the animal model of schizophrenia induced by ketamine

One carbon metabolism in pregnancy: Impact on maternal, fetal and neonatal health

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