Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide

Isung, Josef; Mobarrez, Fariborz; Nordström, Peter; Åsberg, Marie; Jokinen, Jussi

doi:10.3109/15622975.2011.624549

Cited by 86 publications

(87 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous study, we have reported that low plasma levels of VEGF were associated with suicide risk in suicide attempters. 10 VEGF has been increasingly appreciated as a neurotrophic factor. It has pleiotropic properties, and apart from being a vital angiogenic factor, it is having a role in regulating neurogenesis and synaptogenesis, but also regulating glia, in the adult brain.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

2158 – Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters

Isung

Aeinehband

Mobarrez

et al. 2013

European Psychiatry

View full text Add to dashboard Cite

A dysregulated immune system influencing pathways for cytokine regulation and growth factor expression is implicated in the pathophysiology of several neuropsychiatric disorders. Here, we analyzed cerebrospinal fluid (CSF) cytokines and growth factors with an ultra-sensitive immunoassay system in 43 medication-free suicide attempters and 20 healthy male volunteers. CSF vascular endothelial growth factor (VEGF) and CSF interleukin-8 (IL-8) levels were significantly lower in suicide attempters compared with healthy controls. Further, CSF VEGF showed a significant negative correlation with depression severity. CSF IL-6 levels did not differ between suicide attempters and healthy controls. Low CSF levels of VEGF may represent a lack of trophic support to neurons and downregulation of neurogenesis in the hippocampus reflecting more severe depressive states. IL-8 has also been reported as important in neuroprotection as well as having chemokine activity in the innate immune response. The results support a role for an impaired innate immunity and dysregulation of neuroprotection in the pathophysiology of depression and suicidal behavior.

show abstract

Section: Discussionmentioning

confidence: 99%

“…VEGF, IL-6 and IL-8 were analyzed with a high-throughput automated biochip immunoassay system, EvidenceH, Randox Laboratories (Crumlin, UK), see previous study for methods. 10 Statistical analysis. One patient was identified as being clearly both a univariate outlier (3.5 s.d.…”

Section: Subjectsmentioning

confidence: 99%

2158 – Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters

Isung

Aeinehband

Mobarrez

et al. 2013

European Psychiatry

View full text Add to dashboard Cite

show abstract

“…It has been suggested that an elevation of VEGF expression may be a repair response to the neural damage that underlies the pathogenesis of depression [130]. However, depressed patients who had attempted suicide [127] or had completed suicide [131] had lower serum or plasma VEGF levels compared with adequate controls, making these discrepancies very difficult to explain. Numerous antidepressant treatments have been shown to affect VEGF signaling.…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 91%

Neuroadaptations of the 5-HT System Induced by Antidepressant Treatments: Old and New Strategies

Haddjeri¹

2014

AAD

View full text Add to dashboard Cite

Major Depressive Disorder (MDD) is a common illness worldwide with severe socioeconomic consequences. Several hypotheses have been formulated to explain the physiopathology of depression as well as the mechanism of action of antidepressants but two of them had attracted much attention. The dominant monoaminergic hypothesis of depression links the physiopathology of MDD to a deficiency on cerebral serotonin (5-HT) and/or Norepinephrine (NE) levels; however, the relatively new neurogenic and neurotrophic hypothesis raises the possibility of an impaired neuroplasticity and/or depletion of neurotrophic factors in specific networks resulting on their structural deformity and functional impairment. An enormous body of evidence reported particular neuroadaptations following chronic administration of antidepressant drugs. In this review, we describe major adaptive changes in pre-and post-synaptic 5-HT neurotransmission as well as alterations in gene transcription and neurotrophic factors in response to long-term treatment with conventional antidepressants, new putative ones or novel promising drug candidates, all acting via 5-HT system.

show abstract

“…79 It is not understood why the levels of VEGF protein would be elevated, but it may partly be attributable to proinflammatory activity and/or increases in blood-brain barrier permeability in depressed states that causes reduced expression in cerebrospinal fluid. 80 The relationship between VEGF and treatment response is unclear; a recent study found no relationship between either serum VEGF or BDNF with response or depression severity, despite decreases alongside antidepressant treatment. 81 Insulin-like growth factor-1 is an additional factor with neurogenic functions that may be increased in depression, reflecting an imbalance in neurotrophic processes.…”

Section: Growth Factor Findings In Depressionmentioning

confidence: 99%

Biomarkers for Depression: Recent Insights, Current Challenges and Future Prospects

Strawbridge¹,

Young

Cleare³

2018

FOC

View full text Add to dashboard Cite

A plethora of research has implicated hundreds of putative biomarkers for depression, but has not yet fully elucidated their roles in depressive illness or established what is abnormal in which patients and how biologic information can be used to enhance diagnosis, treatment and prognosis. This lack of progress is partially due to the nature and heterogeneity of depression, in conjunction with methodological heterogeneity within the research literature and the large array of biomarkers with potential, the expression of which often varies according to many factors. We review the available literature, which indicates that markers involved in inflammatory, neurotrophic and metabolic processes, as well as neurotransmitter and neuroendocrine system components, represent highly promising candidates. These may be measured through genetic and epigenetic, transcriptomic and proteomic, metabolomic and neuroimaging assessments. The use of novel approaches and systematic research programs is now required to determine whether, and which, biomarkers can be used to predict response to treatment, stratify patients to specific treatments and develop targets for new interventions. We conclude that there is much promise for reducing the burden of depression through further developing and expanding these research avenues.

show abstract

Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide

Abstract: Our study provides further support for a role of inflammation in the pathophysiology of suicidality. VEGF may be related with suicide risk.

Cited by 86 publications

References 37 publications

2158 – Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters

2158 – Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters

Neuroadaptations of the 5-HT System Induced by Antidepressant Treatments: Old and New Strategies

Biomarkers for Depression: Recent Insights, Current Challenges and Future Prospects

Contact Info

Product

Resources

About