Low plasma eicosapentaenoic acid concentration as a possible risk factor for intracerebral hemorrhage

Ikeya, Yoshimori; Fukuyama, Naoto; Mori, Hiromu

doi:10.1016/j.nutres.2015.01.003

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…Regarding the correlation between serum docosahexaenoic acid and the severity of WMH, Ikeya et al . reported the importance of aging . Diabetes mellitus, dyslipidemia and hypertension are well‐known risk factors for atherosclerosis; however, they failed to be identified as significant risk factors in the present study.…”

Section: Discussioncontrasting

confidence: 67%

Severity of white matter hyperintensities in older adults aged in their mid 80s and its relationship with hemodynamic and cardiac parameters

Todoroki

Ikeya

Fukui

et al. 2015

Geriatrics Gerontology Int

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Aim:In the present study, we analyzed the severity of white matter hyperintensities detected on magnetic resonance imaging of the brain in older Japanese adults who were aged in their mid 80s, and examined its relationships with the clinical parameters. Methods:To identify factors related to the severity of white matter hyperintensities in 33 older adult attendees of our outpatient clinic and 17 older adults living in a group home, we carried out logistic regression analyses and/or correlation analyses. Results:Cognitive function and activities of daily living were significantly correlated with the severity of white matter hyperintensities. Multivariate analysis identified activities of daily living, but not cognitive function, as being independently associated with the severity of white matter hyperintensities. Several hemodynamic and cardiac parameters, including diastolic blood pressure, hemoglobin, serum level of N-terminal pro-brain natriuretic peptide, cardiothoracic ratio on the chest X-ray, severity of supraventricular arrhythmias on a Holter electrocardiogram and serum levels of docosahexaenoic acid, were significantly correlated with the severity of white matter hyperintensities. In contrast, the serum cholesterol, glycosylated hemoglobin value and systolic blood pressure were not correlated with the severity of white matter hyperintensities. Conclusions:The severity of white matter hyperintensities detected on magnetic resonance imaging of the brain in older Japanese patients aged in their mid 80s was significantly correlated with activities of daily living, hemodynamic and cardiac parameters, and the serum level of docosahexaenoic acid. Geriatr Gerontol Int 2015; 15 (Suppl. 1): 66-73.

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Section: Discussioncontrasting

confidence: 67%

Severity of white matter hyperintensities in older adults aged in their mid 80s and its relationship with hemodynamic and cardiac parameters

Todoroki

Ikeya

Fukui

et al. 2015

Geriatrics Gerontology Int

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“…An association between serum long-chain n-3 PUFA levels and stroke risk has been reported previously in cross-sectional studies. 39 , 40 The impact of marine n-3 PUFA levels on ischemic stroke may extend beyond the risk of incident event. Lower plasma proportions of EPA and DHA have been shown to be independently associated with increased ischemic stroke severity and, for DHA, poor functional outcomes at 90 days after stroke.…”

Section: Resultsmentioning

confidence: 99%

Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart Study

Harris

Tintle

Etherton

et al. 2018

Journal of Clinical Lipidology

110

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BACKGROUND:The extent to which omega-3 fatty acid status is related to risk for death from any cause and for incident cardiovascular disease (CVD) remains controversial.OBJECTIVE:To examine these associations in the Framingham Heart Study.DESIGN:Prospective and observational.SETTING:Framingham Heart Study Offspring cohort.MEASUREMENTS:The exposure marker was red blood cell levels of eicosapentaenoic and docosahexaenoic acids (the Omega-3 Index) measured at baseline. Outcomes included mortality (total, CVD, cancer, and other) and total CVD events in participants free of CVD at baseline. Follow-up was for a median of 7.3 years. Cox proportional hazards models were adjusted for 18 variables (demographic, clinical status, therapeutic, and CVD risk factors).RESULTS:Among the 2500 participants (mean age 66 years, 54% women), there were 350 deaths (58 from CVD, 146 from cancer, 128 from other known causes, and 18 from unknown causes). There were 245 CVD events. In multivariable-adjusted analyses, a higher Omega-3 Index was associated with significantly lower risks (P-values for trends across quintiles) for total mortality (P = .02), for non-CVD and non-cancer mortality (P = .009), and for total CVD events (P = .008). Those in the highest (>6.8%) compared to those in the lowest Omega-3 Index quintiles (<4.2%) had a 34% lower risk for death from any cause and 39% lower risk for incident CVD. These associations were generally stronger for docosahexaenoic acid than for eicosapentaenoic acid. When total cholesterol was compared with the Omega-3 Index in the same models, the latter was significantly related with these outcomes, but the former was not.LIMITATIONS:Relatively short follow-up time and one-time exposure assessment.CONCLUSIONS:A higher Omega-3 Index was associated with reduced risk of both CVD and allcause mortality.

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“…Intracerebral hemorrhage (ICH) is a kind of common and lethal stroke, and the therapy of which is still unclear [1], its ratio in all of the strokes is about 10%-15% and proved to be correlated with high incidence and mortality [2]. As it was confirmed by previous studies, the risk factors of ICH include low plasma eicosapentaenoic acid concentration [3], untreated hypertension [4] and oral anticoagulation therapy [5]. According to a recent research which was determined to explore ICH diagnosis, there were no concrete methods of diagnosis that could be adopted before the disease occurred, which caused a delay of therapy [6].…”

Section: Introductionmentioning

confidence: 94%

RETRACTED ARTICLE: MicroRNA-93 regulates the neurological function, cerebral edema and neuronal apoptosis of rats with intracerebral hemorrhage through TLR4/NF-κB signaling pathway

et al. 2019

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In recent years, many studies have unraveled the impact of microRNAs (miRNAs) in intracerebral hemorrhage (ICH). This study aims to explore the role of miR-93 in modulating neurological function, cerebral edema and neuronal apoptosis of rats with ICH by regulating TLR4/NF-κB signaling pathway. ICH models were constructed using Ⅶ collagenase method. The successfully modeled rats were injected with miR-93 antagomir, TLR4/NF-κB signaling pathway activator or inhibitor together with their controls. The expression of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β) and vascular endothelial growth factor (VEGF) was measured using enzyme-linked immunosorbent assay (ELISA). The expression of human aquaporin 4 (AQP-4), Caspase-3, Bax, Bcl-2 and TLR4/NF-κB signaling pathway-related proteins was also measured. MiR-93, TLR4 and NF-κB were all highly expressed in ICH, reduced miR-93 and inhibited TLR4/NF-κB signaling pathway could improve neurological function and suppress inflammation in ICH rats. Moreover, down-regulated miR-93 and suppressed TLR4/NF-κB signaling pathway were able to attenuate cerebral edema and abate pathological lesion. We have also found in this research that miR-93 knockdown as well as inhibited TLR4/NF-κB signaling pathway could relieve neuronal apoptosis in ICH rats. This study suggests that reduced miR-93 alleviates the neurological function and cerebral edema as well as repressed neuronal apoptosis of ICH rats via the inhibited activation of TLR4/NF-κB signaling pathway.

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Low plasma eicosapentaenoic acid concentration as a possible risk factor for intracerebral hemorrhage

Cited by 9 publications

References 35 publications

Severity of white matter hyperintensities in older adults aged in their mid 80s and its relationship with hemodynamic and cardiac parameters

Severity of white matter hyperintensities in older adults aged in their mid 80s and its relationship with hemodynamic and cardiac parameters

Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart Study

RETRACTED ARTICLE: MicroRNA-93 regulates the neurological function, cerebral edema and neuronal apoptosis of rats with intracerebral hemorrhage through TLR4/NF-κB signaling pathway

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