Low Plasma Brain-Derived Neurotrophic Factor and Childhood Physical Neglect Are Associated with Verbal Memory Impairment in Major Depression—A Preliminary Report

Grassi‐Oliveira, Rodrigo; Stein, Lílian Milnitsky; Lopes, Rodrigo Pestana; Teixeira, Antônio Lúcio; Bauer, Moisés Evandro

doi:10.1016/j.biopsych.2008.02.023

Cited by 117 publications

(85 citation statements)

References 32 publications

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“…However, Gulec et al failed to find a relationship between CPN and depression [21]. Moreover, Grassi-Oliveira et al also failed to find an effect of CPN on the severity of depressive symptom, which is consistent with the present finding [22]. No published studies have examined the association between CPN and the response to antidepressants in MDD.…”

Section: Discussionsupporting

confidence: 82%

Influence of Childhood Physical Neglect on Depression: Potential Moderation by a Polymorphism in the QKI Gene

Geng¹,

Shi²

2016

J Depress Anxiety

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of genetic and environmental factors (e.g., stress) could initially lead to glial cell pathology and consequently contribute to neuronal pathology later in life, as depressive illnesses progresses [13].For these reasons, the present study sought to (i) examine the potential impact of CPN on general functioning, adult depressive symptoms and antidepressant treatment response, and (ii) test whether genetic polymorphisms related to ODC and myelin function interact with CPN to affect adult depressive symptoms and antidepressant response. Methods Study design and subjectsSubjects were Chinese Han individuals aged between 18 to 60 years, with a diagnosis of new or recently relapsed major depression disorder (MDD). The baseline scores on the 17-item Hamilton Depression Rating Scale (HAMD-17) were>17. Exclusion criteria used for this study have been previously reported [14]. All of the subjects were informed of the potential risks and benefits of the study and gave their informed consent prior to their participation in the study. AbstractObjective: Childhood physical neglect (CPN) is a common but often overlooked form of abuse that may contribute to depression. We aimed at examining the potential impact of CPN and its interactions with genes related to oligodendrocytes (ODCs) and myelin function on adult depressive symptoms and antidepressant treatment response.Methods: A group of 209 Chinese Han patients with major depressive disorder (MDD) completed the Hamilton Depression Scale-17 (HAMD-17) at baseline and after 8 weeks antidepressant treatment. The Childhood Trauma Questionnaire was used to evaluate the occurrence of childhood physical neglect. Twelve single nucleotide polymorphisms (SNPs) in functional regions were successfully genotyped in seven genes associated with ODCs and myelin function. Results:Childhood physical neglect is related to education and social support, especially the subjective social support of those who experience CPN. The GG genotype of the 3'UTR functional polymorphism rs715020 in the QKI gene showed significant association with diminished effects of childhood physical neglect on adult depressive symptoms(P=.003) even after the Bonferroni correction. No significant interactions between candidate genes and CPN on antidepressant response were observed. Conclusion:These results indicate that CPN are potentially associated with ODCs and myelin-related gene QKI, and may influence adult depressive symptoms in major depression disorder (MDD) patients. This finding needs to be further replicated in a larger sample.

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Section: Discussionsupporting

confidence: 82%

Influence of Childhood Physical Neglect on Depression: Potential Moderation by a Polymorphism in the QKI Gene

Geng¹,

Shi²

2016

J Depress Anxiety

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“…8 studies comparing serum BDNF levels in depressed subjects before and after antidepressant treatment were identified and included for our second analysis. Although there are now a few recent studies suggesting plasma BDNF content is also decreased in depressed subjects (19,(21)(22)(23), this data was not included in this analysis in order to minimize potential confounds.…”

Section: Studiesmentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen

Duman

Sanacora

2008

Biological Psychiatry

1,082

715

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“…4 Consistent with the view that regulation of BDNF levels has effects on memory processes, previous studies of potential neurobiological factors of cognitive impairment found that memory deficits are associated with changes in peripheral BDNF levels in patients with psychiatric disorders. 5,6 In addition, it has been suggested that BDNF synthesis declines throughout the life-span, 7 suggesting a specific neurobiological mechanism of age-related decline in human memory.…”

Section: Introductionmentioning

confidence: 99%

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

Azeredo

Nardi

Levandowski

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged 4 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.

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Low Plasma Brain-Derived Neurotrophic Factor and Childhood Physical Neglect Are Associated with Verbal Memory Impairment in Major Depression—A Preliminary Report

Cited by 117 publications

References 32 publications

Influence of Childhood Physical Neglect on Depression: Potential Moderation by a Polymorphism in the QKI Gene

Influence of Childhood Physical Neglect on Depression: Potential Moderation by a Polymorphism in the QKI Gene

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

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