Low plasma androgens in women with systemic lupus erythematosus

Lahita, Robert G.; Bradlow, H. Leon; Ginzler, Ellen M.; Pang, Songya; New, Maria I.

doi:10.1002/art.1780300301

Cited by 257 publications

(104 citation statements)

References 25 publications

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“…The 16␣ metabolites exert potent estrogenic activity and may be associated with activity of the disease. On the other hand, plasma androgen levels have been shown to be significantly lower in SLE patients, especially during disease activity (31). The dysregulation of the levels of androgens and estrogen metabolites may be responsible for the pathogenesis of SLE.…”

Section: Discussionmentioning

confidence: 99%

Ovarian failure and flares of systemic lupus erythematosus

Mok

Wong

Lau

1999

Arthritis & Rheumatism

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Objective. To study the effects of ovarian failure on disease flares in systemic lupus erythematosus (SLE).Methods. Fifty-four female premenopausal SLE patients who were under the age of 45 years and treated with continuous oral cyclophosphamide (CYC) for no more than 12 months were studied. All patients had been followed up for >5 years following CYC treatment. Demographic characteristics, clinical and serologic profiles, and information concerning disease flares were recorded. Comparison of the number of severe and mild/moderate flares during the first 5 years after CYC treatment was made between patients who developed CYC-induced ovarian failure and those who did not.Results. Fourteen SLE patients had documented ovarian failure with hypoestrogenemia within 2 years after CYC treatment. Compared with the menstruating group of patients, those who developed ovarian failure were significantly older at the time of CYC therapy (mean 37.9 versus 25.5 years; P < 0.001), but otherwise no significant differences in organ manifestations and autoantibody profiles between the 2 groups were observed. Both the ovarian failure group and menstruating group of patients had similar SLE Disease Activity Index scores at the time of CYC treatment (mean 15.6 versus 17.7; P ‫؍‬ 0.16), and had comparable treatment durations (mean 8. Conclusion. This study provides an important clinical observation to support the notion that ovarian failure with hypoestrogenemia is protective against lupus flares and emphasizes the importance of estrogen status in the determination of disease activity in SLE.

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Section: Discussionmentioning

confidence: 99%

Ovarian failure and flares of systemic lupus erythematosus

Mok

Wong

Lau

1999

Arthritis & Rheumatism

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“…Several studies have assessed serum estradiol concentrations in adult patients with SLE (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47); those that included healthy age-matched controls and provide accessible data for analysis are shown in Table 1 and Figure 1. Two of 8 investigations involving adult female patients with SLE showed significantly increased serum estradiol concentrations in lupus patients compared with controls.…”

Section: Serum 17␤-estradiolmentioning

confidence: 99%

Sex hormones and systemic lupus erythematosus: Review and meta‐analysis

McMurray¹,

May²

2003

Arthritis & Rheumatism

144

120

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“…4). Other factors implicated in the development or progression of SLE include altered cytokine levels (5), modulated sex hormone metabolism (6), increased apoptosis (7), and elevated levels of oxidative stress. With respect to oxidative stress, evidence of increased levels of phospholipid oxidation products, particularly in patients with antiphospholipid antibodies (8) has been reported, as well as elevated plasma DNA oxidation products, such as 8-hydroxydeoxyguanosine (8-oxodG), a product that also appears to be processed abnormally (9).…”

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confidence: 99%

Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus

Morgan¹,

Sturgess²,

Davies³

2005

Arthritis & Rheumatism

120

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Objective. To examine protein oxidation in systemic lupus erythematosus (SLE) and to correlate levels of protein oxidation products with disease activity.Methods. Serum was collected from SLE patients and healthy control subjects. Protein-bound carbonyls and the pro-oxidant enzyme myeloperoxidase (MPO) were quantified by enzyme-linked immunosorbent assay. Protein thiols were quantified using 5,5-dithionitrobenzoic acid. Protein-bound amino acids and methionine, tyrosine, and phenylalanine oxidation products were quantified by acid hydrolysis and highperformance liquid chromatography. Disease activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Levels of antidouble-stranded DNA (anti-dsDNA) antibodies were measured by radioimmunoassay.Results. Compared with control subjects, SLE patients exhibited elevated levels of protein carbonyls (0.108 ؎ 0.078 versus 0.064 ؎ 0.028 nmoles/mg of protein; P ‫؍‬ 0.046), decreased levels of protein thiols (3.9 ؎ 1.1 versus 4.9 ؎ 0.7 nmoles/mg of protein; P ‫؍‬ 0.003), decreased levels of protein-bound methionine (P ‫؍‬ 0.0007), and increased levels of protein-bound methionine sulfoxide (P ‫؍‬ 0.0043) and 3-nitrotyrosine (P ‫؍‬ 0.0477). SLE patients with high SLEDAI scores or elevated anti-dsDNA antibody levels exhibited increased oxidation compared with patients with low SLEDAI scores or low antibody levels. Serum MPO levels were decreased in SLE patients (P ‫؍‬ 0.03), suggesting that this enzyme is not responsible for the enhanced protein oxidation.Conclusion. We found elevated levels of multiple markers of protein oxidation in sera from SLE patients compared with controls, and these levels correlated with disease activity. The findings suggest that protein oxidation may play a role in the pathogenesis of chronic organ damage in SLE.

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Low plasma androgens in women with systemic lupus erythematosus

Cited by 257 publications

References 25 publications

Ovarian failure and flares of systemic lupus erythematosus

Ovarian failure and flares of systemic lupus erythematosus

Sex hormones and systemic lupus erythematosus: Review and meta‐analysis

Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus

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