Low-phase angle in body composition measurements correlates with prolonged hospital stay in head and neck cancer patients

Lundberg, Marie; Dickinson, Amy; Nikander, Pia; Orell, Helena; Mäkitie, Antti

doi:10.1080/00016489.2019.1566779

Cited by 22 publications

(35 citation statements)

References 20 publications

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“…This study was underpowered to confirm the association between PhA and mortality that was reported in a large multicenter ICU study. 47 Nonetheless, we found that a low PhA (<5°) was predictive of an increased length of hospital stay, in keeping with previous studies showing similar results in ICU, 19 postpancreaticoduodenectomy, 48 head and neck cancer, 49 and heart failure 50 patients.…”

Section: Discussionsupporting

confidence: 91%

Associations Between Nutrition Markers and Muscle Mass on Bioimpedance Analysis in Patients Receiving Parenteral Nutrition

Sunario

Wibrow

Jacques

et al. 2020

J Parenter Enteral Nutr

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Background Parenteral nutrition (PN) is used for malnourished patients and those intolerant of enteral nutrition. This pilot study assessed repeatability of bioimpedance analysis (BIA) in critically ill patients and association with nutrition markers and patients’ length of hospital stay. Methods Twenty‐two patients receiving PN, after major surgery or during critical illness, were enrolled and underwent serial BIA and Subjective Global Assessment (SGA) by a dietitian. Repeatability of BIA was assessed by repeating BIA measurements within 10 minutes in 18 of the 22 study patients (82%). Results All BIA parameters were repeatable with strong intraclass correlation coefficients (>0.78). Phase angle (PhA), reflective of muscle mass, was significantly associated with serum albumin (R2 = 0.198, P < .001), total lymphocyte count (R2 = 0.083, P = .018), and body mass index (R2 = 0.084, P = .015). Of the 48 SGAs performed, 4 were considered severely malnourished, and all were associated with low PhA (<5°) compared with only 53% and 33% for those considered to be moderately malnourished and well nourished, respectively (χ2 test: P = .042). Low PhA was significantly associated with an increased length of hospital stay compared with those without low PhA (median 36 vs 16 days, respectively; P < .001). Conclusion BIA is repeatable in critically ill patients receiving PN. Low PhA was prevalent for those judged as severely malnourished and was associated with reduced total lymphocyte count and serum albumin and prolonged length of hospital stay compared with those with a higher PhA.

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Section: Discussionsupporting

confidence: 91%

Associations Between Nutrition Markers and Muscle Mass on Bioimpedance Analysis in Patients Receiving Parenteral Nutrition

Sunario

Wibrow

Jacques

et al. 2020

J Parenter Enteral Nutr

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“…The standardized procedure internationally to measure BBVs [4][5][6][7][8][9] was used in this study. Measurements were carried out in the morning hours (from 8 to 9 am) by a trained nurse.…”

Section: Measurement Proceduresmentioning

confidence: 99%

Correlation and principal component analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients. Pilot study

Regüeiferos

Luna

Brooks³

et al. 2022

Preprint

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Background: Bioelectrical impedance analysis has been used in cancer patients. The aim of this study is to propose an integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients for the integral evaluation and possible prognostic of them.Methods: This Pilot study was retrospective and cross-sectional and 23 patients aged 53-82 years participated in it. The electrical resistance and capacitive electrical reactance were measured with the Bodystat Quadscan® 4000 analyzer. The electrical impedance modulus and the phase angle were calculated. The serum concentrations of epidermal growth factor, CYFRA21-1 and CA 72-4 were quantified. Correlations/associations among variables and the principal component analysis were suggested.Results: The majority of patients had tumor markers, electrical resistance and the phase angle in their respective normal ranges. The capacitive electrical resistance was below its normal range. Minimum, low and moderate grades of linear correlation/association prevailed among studied variables. The principal components I and II were interpreted as prognosis and body energetic reserve of the patient, respectively.Conclusions: It is concluded that the clinical, bioelectrical and functional variables allow the integral analysis and possible prognosis of newly diagnosed lung cancer adult patients. The decrease of the capacitive electrical reactance is the most influence to the loss of the body energetic reserve that leads to alterations of the overall health, tiredness and decrease of weight and body mass index of these patients.

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“…Body mass and composition analyses will be performed using a bioelectrical impedance meter (SECA mBCA 515, SECA, Hamburg, Germany), validated in comparison to different robust methods assessing body composition, such as air-displacement plethysmography, dual-energy X-ray absorptiometry, and deuterium dilution (55). The bioelectrical impedance meter is also regularly used in studies investigating body composition in cancer patients (56)(57)(58)(59). We will quantify body mass, fat free mass, fat mass, skeletal muscle mass, visceral fat, and body water repartition.…”

Section: Body Composition and Cachexiamentioning

confidence: 99%

Evolution of Physical Status From Diagnosis to the End of First-Line Treatment in Breast, Lung, and Colorectal Cancer Patients: The PROTECT-01 Cohort Study Protocol

et al. 2020

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Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life. However, the characterization of patients' physical status and exercise tolerance and, most importantly, their evolution throughout cancer treatment may represent the first step in efficiently counteracting their development with prescribed and tailored exercise training. In this context, the aim of the PROTECT-01 study will be to investigate the evolution of physical status, from diagnosis to the end of first-line treatment, of patients with one of the three most common cancers (i.e., lung, breast, and colorectal). Methods: The PROTECT-01 cohort study will include 300 patients equally divided between lung, breast and colorectal cancer. Patients will perform a series of assessments at three visits throughout the treatment: (1) between the date of diagnosis and the start of treatment, (2) 8 weeks after the start of treatment, and (3) after the completion of first-line treatment or at the 6-months mark, whichever occurs first. For each of the three visits, subjective and objective fatigue, maximal voluntary force, body composition, cachexia, physical activity level, quality of life, respiratory function, overall physical performance, and exercise tolerance will be assessed. Discussion: The present study is aimed at identifying the nature and severity of maladaptation related to exercise intolerance in the three most common cancers. Therefore, our results should contribute to the delineation of the needs of each group of patients and to the determination of the most valuable exercise interventions in order to counteract these maladaptations. This descriptive and comprehensive approach is a prerequisite in order to elaborate, through future interventional research projects, tailored exercise strategies to counteract specific symptoms that are potentially cancer type-dependent and, in fine , to improve the health and quality of life of cancer patients. Moreover, our concomitant focus on fatigue and cachexia will provide insightful information about two factors that may have substantial interaction but require further investigation. Trial registration: This prospective study has been registered at ClinicalTrials.gov (NCT03956641), May, 2019.

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Low-phase angle in body composition measurements correlates with prolonged hospital stay in head and neck cancer patients

Cited by 22 publications

References 20 publications

Associations Between Nutrition Markers and Muscle Mass on Bioimpedance Analysis in Patients Receiving Parenteral Nutrition

Associations Between Nutrition Markers and Muscle Mass on Bioimpedance Analysis in Patients Receiving Parenteral Nutrition

Correlation and principal component analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients. Pilot study

Evolution of Physical Status From Diagnosis to the End of First-Line Treatment in Breast, Lung, and Colorectal Cancer Patients: The PROTECT-01 Cohort Study Protocol

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