Low Perioperative Serum Prealbumin Predicts Early Recurrence after Curative Pulmonary Resection for Non‐Small‐Cell Lung Cancer

Kawai, Hideki; Ota, Hideki

doi:10.1007/s00268-012-1766-y

Cited by 70 publications

(60 citation statements)

References 51 publications

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“…However, there was no correlation between serum prealbumin and pathological stage. By multivariate analysis, the authors showed that low perioperative serum prealbumin could be an independent prognostic factor of poor outcome (23). One limitation of our study was the impossibility to analyse the contribution of age in the difference in prealbumin levels between groups, due to the relatively small number of patients.…”

Section: Discussionmentioning

confidence: 94%

Assessment of preoperative and postoperative prealbumin in thoracic surgery – a two months experience in a Romanian university hospital / Evaluarea preoperatorie şi postoperatorie a prealbuminei în chirurgia toracică - experiența de 2 luni a unui spital universitar din România

Trufa¹,

Arhire²,

Grigorescu³

et al. 2015

Romanian Review of Laboratory Medicine

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Section: Discussionmentioning

confidence: 94%

Assessment of preoperative and postoperative prealbumin in thoracic surgery – a two months experience in a Romanian university hospital / Evaluarea preoperatorie şi postoperatorie a prealbuminei în chirurgia toracică - experiența de 2 luni a unui spital universitar din România

Trufa¹,

Arhire²,

Grigorescu³

et al. 2015

Romanian Review of Laboratory Medicine

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“…Pre-albumin is also currently used to evaluate treatment outcome and nutritional status in colon, esophagus, ovarian and lung cancers. 10,16,17 Another study suggested that pre-albumin levels can be used to predict the early recurrence of colorectal cancer. In there study, albumin was found to be more sensitive than pre-albumin in predicting the recurrence of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Albumin, prealbumin and CRP levels can be used to predict prognosis in gastric cancer

Rao¹,

Phanikumar²,

Kumar³

2017

Int Surg J

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Background: malnutrition and systemic inflammatory response in cancers result in a shorter survival rate, reduced treatment response and a higher rate of complications associated with therapy. Prealbumin, albumin and CRP Levels has utility as a prognostic indicator of cancer survival in cancer. The objective of this study was to albumin, pre-albumin and CRP levels of the patients who underwent surgery for gastric cancer were prospectively recorded and retrospectively evaluated.Methods: Study was done for period of 1 year in patients underwent surgery for gastric cancer. Details noted from records are as age, gender, duration of hospital stay, TNM stage, and preoperative albumin, pre-albumin and CRP levels.Results: A total number of 44 patients, 32 (72.7%) men and 12 (27.7%) women, were included in the study. The mean age was 64.1 (43-89) years. The mean duration of hospital stay was 12.8 (4-46) days. Preoperative albumin levels were below the expected range in 16 (41%) of 44 patients. Mean age of the patients with normal and decreased albumin levels was 62.7±12.8 and 65.3±12.3 years, respectively; albumin levels were insignificantly associated with the age (p = 0.54). When these 16 cases were evaluated in terms of disease stage-3 had 11(68.7%). Preoperative pre-albumin levels were decreased in 23 (53%) of 44 cases. Among the cases with decreased pre-albumin levels, stage 1 and 3 had 5 (21.7%) cases. There was a significant correlation between the TNM stage and pre-albumin levels (P = 0.014). CRP levels were elevated in 19 (43.2%) of 44 cases with CRP. Among these Stage-3 had 8 cases, 4 (42.1%). There was no significant correlation between disease stage, presence of metastatic lymph nodes and albumin levels (p>0.05).Conclusions: Preoperative albumin, pre-albumin and CRP levels can be useful to predict prognosis of patients with gastric cancer.

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“…Ho et al, suggested that a decreased pre-albumin level is an independent risk factor in cancer patients and recommended its use for the patients with terminal cancers [19]. On the other hand, pre-albumin is currently used to evaluate treatment outcome and nutritional status in colon [21], esophagus [22], ovarian [23] and lung [24] cancers. Another study suggested that pre-albumin levels can be used to predict the early recurrence of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Can Prealbumin, Albumin and CRP Levels be used to Predict Prognosis in Patients with Gastric Cancer

Üreyen¹

2016

J Surg Surgical Res

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Background: The impact of systemic inflammatory response on carcinogenesis and tumor progression has recently gained much attention. Biochemical markers such as albumin, pre-albumin and C-reactive protein (CRP) are currently used to predict prognosis in several cancer types, and the usefulness of these biomarkers in gastric cancer has become an emerging topic of research. The present study aims to assess the correlation between tumor stage and the levels of pre-albumin, albumin and CRP in patients who underwent surgery for gastric cancer.Methods: Albumin, pre-albumin and CRP levels of the patients who underwent surgery for gastric cancer in our division, were prospectively recorded and retrospectively evaluated. Age, gender, duration of hospital stay, TNM stage, and preoperative albumin, pre-albumin and CRP levels were recorded. Albumin levels lower than 3.5 mg/dL and pre-albumin levels lower than 20 mg/dL were considered to be below the normal range. CRP levels higher than 5 mg/L were considered to be elevated. Patients with another focus of inflammation were excluded from the study.Results: A total number of 41 patients, 32 (78%) men and 9 (22%) women, were included in the study. Albumin levels were significantly associated with the age (p=0.010). There was no significant correlation between disease stage, gender, presence of metastatic lymph nodes and albumin levels (p>0.05). There was a significant correlation between the TNM stage and pre-albumin levels (P=0.014). No significant correlation was demonstrated between pre-albumin levels and the other parameters (P>0.05). The independent variables were not found to be significantly different between the groups with normal and elevated CRP levels (p>0,05) Conclusions:The present study showed that the patients with lymph node metastasis and advanced stage gastric cancer more frequently have decreased levels of albumin and pre-albumin, and elevated levels of CRP. Decreased pre-albumin level was found to be associated with the TNM stage. The albumin levels were found to be decreasing by age. Although we failed to demonstrate a statistically correlation with albumin and CRP, preoperative albumin, pre-albumin and CRP levels may be useful to predict prognosis of patients with gastric cancer.

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Low Perioperative Serum Prealbumin Predicts Early Recurrence after Curative Pulmonary Resection for Non‐Small‐Cell Lung Cancer

Abstract: Low serum prealbumin level in the perioperative period is associated with a poorer prognosis in NSCLC patients and could serve as a marker for identifying patients at high risk, even at an early clinical stage.

Cited by 70 publications

References 51 publications

Assessment of preoperative and postoperative prealbumin in thoracic surgery – a two months experience in a Romanian university hospital / Evaluarea preoperatorie şi postoperatorie a prealbuminei în chirurgia toracică - experiența de 2 luni a unui spital universitar din România

Assessment of preoperative and postoperative prealbumin in thoracic surgery – a two months experience in a Romanian university hospital / Evaluarea preoperatorie şi postoperatorie a prealbuminei în chirurgia toracică - experiența de 2 luni a unui spital universitar din România

Albumin, prealbumin and CRP levels can be used to predict prognosis in gastric cancer

Can Prealbumin, Albumin and CRP Levels be used to Predict Prognosis in Patients with Gastric Cancer

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