Low molecular weight heparin for prevention of venous thromboembolism in patients with lower leg immobilization

Prognosis of venous thromboembolism in orthopaedic surgery or trauma patients and use of thromboprophylaxis

“…Its clinical relevance should therefore not be underestimated. This is contrary to data reported in some studies where most patients had distal DVT in this setting (8,13). Furthermore, only 40% patients with fatal PE in the group of patients with non-surgical trauma had received thromboprophylaxis.…”

Prognosis of venous thromboembolism in orthopaedic surgery or trauma patients and use of thromboprophylaxis

“…Its clinical relevance should therefore not be underestimated. This is contrary to data reported in some studies where most patients had distal DVT in this setting (8,13). Furthermore, only 40% patients with fatal PE in the group of patients with non-surgical trauma had received thromboprophylaxis.…”

Comparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi‐rigid immobilization for isolated non‐surgical below‐knee injury

“…Despite these limitations, we believe fondaparinux 2.5 mg once‐daily subcutaneously may be a valuable therapeutic option in patients with non‐surgical isolated lower‐limb injuries judged to be at increased VTE risk. Importantly, fondaparinux was not associated with increased bleeding risk, in accordance with observations in another recent study in which fondaparinux was administered for 45 days in patients with superficial‐vein thrombosis , and confirming the low bleeding risk in this population as generally observed in non‐surgical contexts . The feasibility of a 45‐day dosage regimen was confirmed by the excellent patient compliance, in a context where > 80% of patients self‐injected the study treatment.…”

Symptomatic venous thromboembolism after non‐operatively treated foot or ankle injury

“…The incidence of symptomatic VTE in our study among foot and ankle patients undergoing below‐knee immobilization for non‐operative injury falls well within the wide range of findings from previous studies, which themselves ranged from 0.0% to 17.3% . The largest retrospective study of which we are aware included 14,777 patients treated non‐operatively for an ankle fracture and demonstrated a rate of symptomatic VTE of 0.22%.…”

Prognosis of venous thromboembolism in orthopaedic surgery or trauma patients and use of thromboprophylaxis

“…Its clinical relevance should therefore not be underestimated. This is contrary to data reported in some studies where most patients had distal DVT in this setting (8,13). Furthermore, only 40% patients with fatal PE in the group of patients with non-surgical trauma had received thromboprophylaxis.…”

Comparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi‐rigid immobilization for isolated non‐surgical below‐knee injury

“…Despite these limitations, we believe fondaparinux 2.5 mg once‐daily subcutaneously may be a valuable therapeutic option in patients with non‐surgical isolated lower‐limb injuries judged to be at increased VTE risk. Importantly, fondaparinux was not associated with increased bleeding risk, in accordance with observations in another recent study in which fondaparinux was administered for 45 days in patients with superficial‐vein thrombosis , and confirming the low bleeding risk in this population as generally observed in non‐surgical contexts . The feasibility of a 45‐day dosage regimen was confirmed by the excellent patient compliance, in a context where > 80% of patients self‐injected the study treatment.…”

Symptomatic venous thromboembolism after non‐operatively treated foot or ankle injury

“…The incidence of symptomatic VTE in our study among foot and ankle patients undergoing below‐knee immobilization for non‐operative injury falls well within the wide range of findings from previous studies, which themselves ranged from 0.0% to 17.3% . The largest retrospective study of which we are aware included 14,777 patients treated non‐operatively for an ankle fracture and demonstrated a rate of symptomatic VTE of 0.22%.…”

Prognosis of venous thromboembolism in orthopaedic surgery or trauma patients and use of thromboprophylaxis

“…Its clinical relevance should therefore not be underestimated. This is contrary to data reported in some studies where most patients had distal DVT in this setting (8,13). Furthermore, only 40% patients with fatal PE in the group of patients with non-surgical trauma had received thromboprophylaxis.…”

Comparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi‐rigid immobilization for isolated non‐surgical below‐knee injury

“…Despite these limitations, we believe fondaparinux 2.5 mg once‐daily subcutaneously may be a valuable therapeutic option in patients with non‐surgical isolated lower‐limb injuries judged to be at increased VTE risk. Importantly, fondaparinux was not associated with increased bleeding risk, in accordance with observations in another recent study in which fondaparinux was administered for 45 days in patients with superficial‐vein thrombosis , and confirming the low bleeding risk in this population as generally observed in non‐surgical contexts . The feasibility of a 45‐day dosage regimen was confirmed by the excellent patient compliance, in a context where > 80% of patients self‐injected the study treatment.…”

Symptomatic venous thromboembolism after non‐operatively treated foot or ankle injury

“…The incidence of symptomatic VTE in our study among foot and ankle patients undergoing below‐knee immobilization for non‐operative injury falls well within the wide range of findings from previous studies, which themselves ranged from 0.0% to 17.3% . The largest retrospective study of which we are aware included 14,777 patients treated non‐operatively for an ankle fracture and demonstrated a rate of symptomatic VTE of 0.22%.…”