Low molecular weight heparin; a novel alternative therapeutic approach for lichen planus

Stefanidou, Maria; Ioannidou, Despoina; Panayiotides, John; Tosca, A.

doi:10.1046/j.1365-2133.1999.03202.x

Cited by 43 publications

(34 citation statements)

References 15 publications

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“…An aberrant or disturbed balance between cytokines may also be implicated in pathological diseases in human, such as lichen planus, psoriasis or dermato®brosis (Lever, 1983). Histologically cutaneous lichen planus is characterized by epidermal hypergranulosis (a pronounced stratum granulosum with high amounts of keratohyalin granula), irregular acanthosis, hyperkeratosis, dermal dibrosis and a dense in®ltrate (Stefanidou et al, 1999). By contrast, absence of granular cells, hyperproliferation and parakeratosis is observed in psoriatic epidermis (Lever, 1983).…”

Section: Role Of Ap-1 In Tumourigenesis and Other Skin Diseasesmentioning

confidence: 99%

Function and regulation of AP-1 subunits in skin physiology and pathology

2001

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The mouse skin has become the model of choice to study the regulation and function of AP-1 subunits in many physiological and pathological processes in vivo and in vitro. Genetically modi®ed mice, in vitro reconstituted skin equivalents and epidermal cell lines were established, in which AP-1-regulated genetic programs of cell proliferation, di erentiation and tumorigenesis can be analysed. Since the epidermis, as our interface with the environment, is subjected to radiation and injury, signal transduction pathways and critical AP-1 members regulating the mammalian stress response could be identi®ed. Regulated expression of important components of the cytokine network, cell surface receptors and proteases, which orchestrate the process of wound healing has been found to rely on AP-1 activity. Here we review our current knowledge on the function of AP-1 subunits and AP-1 target genes in these fascinating ®elds of skin physiology and pathology. Oncogene (2001) 20, 2413 ± 2423.

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Section: Role Of Ap-1 In Tumourigenesis and Other Skin Diseasesmentioning

confidence: 99%

Function and regulation of AP-1 subunits in skin physiology and pathology

2001

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“…3 Lichen Planus may consist the response of antigenic impluse in epidermis as the delayedtype hypersensitivity (DTH) reactions. 1,4 Except the anti-coagulan activity of very low doses of heparin; it is point out that it inhibits type-IV reaction in T-lymphocytes sourced otoimmun diseases and on the allografted mouses.…”

Section: Introductionmentioning

confidence: 99%

“…1 The mucosal accumulations frequently occur and it can rarely cause to nail dystrophy or cicatricial alopecia. There are various clinical types of Lichen Planus and the course of disease is unpredictable.…”

Section: Introductionmentioning

confidence: 99%

“…2 The Lichen Planus is characterized by the interface dermatitis which is occurred intensely infiltration of lymphocytes along dermal-epidermal junction and vacuolar degeneration and destruction of keratinocytes on stratum basale. 1 Apoptosis of T-lymphocytes and keratinocytes which are contained in dermal infiltrate cause the destruction of epidermis. The clinical and histological indicators are similar as chronic graft-versus host reaction.…”

Section: Introductionmentioning

confidence: 99%

“…1 Enoxaparin is low-molecular-weight heparin. The dominances of enoxaparin are longer half-life, easier to dose and more reliable than heparin.…”

Section: Introductionmentioning

confidence: 99%

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The effectiveness of treatment with enoxaparin in lichen planus

Uçmak

Balci²,

Harman³

2012

J Clin Exp Invest

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ÖZETAmaç: Heparin analoglarının düşük dozlarının antiproliferatif ve immünmodülatör etkilerinin olduğu bilinmektedir. Bu çalışmanın amacı; liken planusta düşük doz enoxaparinin etkinliğini değerlendirmektir. Gereç ve yöntem:Liken planus tanısı alan 21 hasta 12 hafta boyunca tedavi edildi. Hastalara her hafta 3 mg enoxaparin subkutan enjeksiyonla yapıldı. Etki ve güven-lik verileri kaydedildi. Bulgular:Tam iyileşme hastaların 15' inde (%71), belirgin düzelme 4' ünde (%19) tespit edildi. Hastaların 2'sinde (%9) tedaviye yanıt alınmadı. Tedavi sonucunda en iyi yanıt, liken planusun akut generalize tipinde görüldü.Sonuç: Sonuç olarak enoxaparin tedavisinin liken planusta etkili bir tedavi seçeneği olabileceği kanaatine varıldı.Anahtar kelimeler: Liken planus, enoxaparin, tedavi ABSTRACT Objectives: As it is known, the low doses of Heparin's analogues have the antiproliferative and immunomodulator activities. This research aims to evaluate the activity of enoxaparin by using the low doses. Materials and methods:21 patients with lichen planus diagnosis have been cured within 12 weeks. 3 mg of enoxaparin has been used for subcutaneus injection to all of patients weekly. The efficient and reliable data has been saved. Results:The perfect recovery has been observed 15 (71%) of 21 patients, the distinct recovery has been observed 4 (19%) of 21 patients. The treatment has not given response on 2 (9%) of 21 patients. The best score has been received on acute generalized type of Lichen Planus. Conclusions:As the result; it has been reported that enoxaparin treatment can be an effective choice in Lichen Planus medication. J Clin Exp Invest 2011; 3(2): 172-173

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Oral Erosive Lichen Planus Treated With Efalizumab

Cheng

Mann²

2006

Arch Dermatol

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Low molecular weight heparin; a novel alternative therapeutic approach for lichen planus

Cited by 43 publications

References 15 publications

Function and regulation of AP-1 subunits in skin physiology and pathology

Function and regulation of AP-1 subunits in skin physiology and pathology

The effectiveness of treatment with enoxaparin in lichen planus

Oral Erosive Lichen Planus Treated With Efalizumab

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