Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer

Tweedle, E; Khattak, Ilyas; Ang, Chin Wee; Nedjadi, Taoufik; Jenkins, Rosalind E.; Park, B Kevin; Kalirai, Helen; Dodson, Andy; Azadeh, Bahram; Terlizzo, Monica; Grabsch, Heike; Mueller, Wolfram; Myint, S.; Clark, Peter; Wong, Hai Ming; Greenhalf, William; Neoptolemos, John P.; Rooney, Paul; Costello, Eithne

doi:10.1136/gut.2009.196626

Cited by 64 publications

(50 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results differed from previous studies in NSCLC [18]. We found that the expression of HSP27 was significantly higher in lung adenocarcinoma tissues, which was consistent with the results in most of the literature [12][13][14][15][16][17]. However, we also found that HSP27 expression did not significantly correlate with the clinicopathological features of lung adenocarcinoma patients.…”

Section: Discussioncontrasting

confidence: 66%

“…HSP27 is overexpressed in many tumors and has a certain correlation with prognosis. Studies have shown that overexpression of HSP27 is associated with poor prognosis of some malignant tumors, such as liver [14], prostate [15], and colon [16] cancers. In contrast, cervical cancer [12] and oral squamous cell carcinoma [13] patients have better prognosis when HSP27 is overexpressed.…”

Section: Discussionmentioning

confidence: 99%

“…The function of HSP27 is associated with the protection of cells from damage induced by a variety of stress factors, cell proliferation and differentiation, and the regulation of apoptotic signal transduction [11]. Previous reports have shown that HSP27 is expressed in many tumors and is associated with tumor malignancy and clinical prognosis [12][13][14][15][16][17]. In lung cancers, HSP27 has been shown to be associated with lung cancer occurrence, development, and prognosis [18]; however, the association between HSP27 expression and the prognosis of lung adenocarcinoma patients is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma

Wang

et al. 2011

Tumor Biol.

View full text Add to dashboard Cite

The purpose of this research was to study the roles of chloride intracellular channel protein 1 (CLIC1) and heat shock protein 27 (HSP27) in the clinical pathology of lung adenocarcinoma and to explore whether the expression of CLIC1 and HSP27 can be used as independent factors for the prediction of recurrence and prognosis after radical resection of lung adenocarcinoma. One hundred and three paraffin sections of lung adenocarcinoma tissues were collected, and the expression of CLIC1 and HSP27 was detected in these tumors using immunohistochemistry. The correlation of the expression of these two proteins with clinicopathological parameters and prognosis was statistically analyzed. In the 103 samples, the expression of HSP27 and CLIC1 was strongly positive in 61 (59.2%) and 49 cases (47.6%), respectively. Statistical analysis showed that the expression level of HSP27 did not significantly correlate with the patient's age, sex, degree of tumor differentiation, T staging of tumors, and TNM staging of tumors (p > 0.05), whereas the expression of CLIC1 did significantly correlate with T staging of tumors (p = 0.029). Univariate analysis indicated that the patient's ECOG score, T staging, N staging, TNM staging, and CLIC1 expression correlated with prognosis (p = 0.031, 0.001, 0.011, 0.013, and <0.001, respectively). Multivariate statistical analysis showed that age, T staging, and CLIC1 expression were independent associated factors for predicting the 5-year survival rate of patients (p = 0.026, 0.004, and <0.001, respectively). Age, T staging, and CLIC1 expression significantly correlated with the overall survival of post-operative lung adenocarcinoma patients. CLIC1 may be closely associated with the occurrence and development of lung adenocarcinoma and may be used as an effective marker for predicting the prognosis of this disease.

show abstract

Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma

Wang

et al. 2011

Tumor Biol.

View full text Add to dashboard Cite

show abstract

“…The cause of that outcome may be closely related to tissue-specific expression. HSP27 has been reported to be overexpressed and associated with poor prognosis in many human cancers, including breast, rectal, gastric, lung, liver and prostate cancers (33)(34)(35)(36). Contrary to the findings in most cancers, in human esophageal squamous cell carcinoma (HESCC), the expression of HSP27 was low, and this low expression was correlated with poor prognosis (37,38).…”

Section: Discussionmentioning

confidence: 96%

HSP47 is associated with the prognosis of laryngeal squamous cell carcinoma by inhibiting cell viability and invasion and promoting apoptosis

et al. 2017

View full text Add to dashboard Cite

Abstract. Heat shock protein 47 (HSP47) is a 47 kDa collagen binding protein that has a close relationship with the development and progression of tumours. However, little is known concerning the expression profile of HSP47 in laryngeal squamous cell carcinoma (LSCC) patients and there is still insufficient data concerning the underlying mechanisms. The aim of the present study was to explore the expression of HSP47 in LSCC and provide an overview of its association with tumourigenicity and clinical prognosis. The expression of HSP47 in LSCC and adjacent non-cancerous laryngeal tissues was assessed via western blotting and immunohistochemical studies. The prognostic significance of HSP47 expression was analysed using a Kaplan-Meier survival curve. To investigate the influence of HSP47 on the viability, invasion and apoptosis of a LSCC cell line, we performed an in vitro analysis with plasmid vectors and small interfering RNA (siRNA). Our results showed that HSP47 protein expression in the LSCC tissues was markedly decreased compared to that noted in the adjacent non-cancerous tissues, and low expression of HSP47 was correlated with poor prognosis in LSCC patients. Upregulation of HSP47 via plasmid vectors inhibited the proliferation, reduced the invasive ability, increased the sensitivity to cisplatin chemotherapy, promoted apoptosis, and induced the G1 phase arrest of LSCC cells in vitro. The expression of apoptosis-regulating proteins was also altered when HSP47 was upregulated, involving increased expression of cleaved caspase-7/-8/-9, PARP, and Bax and decreased expression of Bcl-2. Our present data suggest that HSP47 is an important prognostic factor and an attractive therapeutic target in LSCC due to its influence on the biological behaviour of LSCC cells.

show abstract

“…At the end of CRS, i.e., at the beginning of HIPEC, Hsp27 levels significantly increased in patients with PC, but not in those with cancer or a history of cancer who underwent abdominal surgery. Hsp27 expression has been described as an independent prognostic factor for patients with ovarian carcinomas, constituting 36 % of those in groups 1, and in patients with rectal cancer (Geisler et al 2000;Tweedle et al 2010). Moreover, in patients without cancer with inflammatory disease, abdominal surgery did not increase Hsp27 levels.…”

Section: Discussionmentioning

confidence: 89%

Impact of hyperthermic intraperitoneal chemotherapy on Hsp27 protein expression in serum of patients with peritoneal carcinomatosis

Képénékian

Aloy

Magné

et al. 2013

Cell Stress and Chaperones

View full text Add to dashboard Cite

show abstract

Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer

Cited by 64 publications

References 53 publications

The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma

The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma

HSP47 is associated with the prognosis of laryngeal squamous cell carcinoma by inhibiting cell viability and invasion and promoting apoptosis

Impact of hyperthermic intraperitoneal chemotherapy on Hsp27 protein expression in serum of patients with peritoneal carcinomatosis

Contact Info

Product

Resources

About