Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma

Wu, Gang; Wang, Yawei; Lu, Xiaojun; He, Hui; Liu, Haiyang; Meng, Xiangyu; Xia, Shuguan; Zheng, Kunming; Liu, Boqian

doi:10.1186/s12885-015-1214-0

Cited by 35 publications

(26 citation statements)

References 28 publications

(25 reference statements)

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“…It was also demonstrated that the miR-520/373 family has a tumor-suppressive role attributed to inhibition of the NFkB and TGFb signaling pathways (30). Furthermore, low miR-372 expression was correlated with poor prognosis and tumor metastasis in HCC (42). Moreover, the miRNA family was also shown to be a tumor suppressor gene in cervical carcinoma (43), endometrial adenocarcinoma (44) and ovarian carcinoma (45).…”

Section: Discussionmentioning

confidence: 97%

The E2F1–miR-520/372/373–SPOP Axis Modulates Progression of Renal Carcinoma

Ding

Wang

et al. 2018

Cancer Research

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Although renal cell carcinoma (RCC) is the most malignant urologic cancer, its pathogenesis remains unclear, and effective treatments for advanced RCC are still lacking. Here, we report that a novel E2F1-miR-520/372/373-SPOP axis controls RCC carcinogenesis. Speckle-type POZ protein (SPOP) was upregulated in over 90% of RCC tissues, whereas the miR-520/372/ 373 family was downregulated and correlated inversely with SPOP protein levels in RCC tissues. The miR-520/372/373 family targeted the SPOP 3 0-UTR and suppressed SPOP protein expression, leading to elevation of PTEN and DUSP7 levels and, consequently, decreased proliferation, invasion/ migration, and metastasis of RCC cells in vitro and in vivo. Tail-vein delivery of therapeutic miR-520/372/373 family significantly decreased both tumor size and lung metastasis ratio in mice bearing orthotopic xenograft tumors. Decreased expression of miR-520/372/373 family was mediated by transcription factor E2F1. In conclusion, our results demonstrate that the E2F1-miR-520/372/373-SPOP axis functions as a key signaling pathway in RCC progression and metastasis and represents a promising opportunity for targeted therapies. Significance: These findings show that the E2F1-miR-520/ 372/373 family-SPOP axis promotes RCC progression, thereby contributing to our understanding of RCC pathogenesis and unveiling new avenues for more effective targeted therapies. Cancer Res; 78(24); 6771-84. Ó2018 AACR.

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Section: Discussionmentioning

confidence: 97%

The E2F1–miR-520/372/373–SPOP Axis Modulates Progression of Renal Carcinoma

Ding

Wang

et al. 2018

Cancer Research

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“…In this study, we selected miR-372 because of its wide range of functional regulation in many types of human cancers (Cho et al, 2009;Lai et al, 2012;Gu et al, 2013;Wu et al, 2015). In this study, 20 pairs of serum samples were collected from patients with PCa and healthy control subjects for further confirming the pattern of expression of miR-372 in PCa.…”

Section: Mirna-372 Is Downregulated In Pcamentioning

confidence: 93%

microRNA-372 Suppresses Migration and Invasion by Targeting p65 in Human Prostate Cancer Cells

Kong

Qian²,

Duan

et al. 2016

DNA and Cell Biology

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Prostate cancer (PCa) is one of the most prevalent malignant tumors. microRNAs (miRNAs) play an important role in cancer initiation, progression, and metastasis, and their roles in PCa are becoming more apparent. In this study, we found that microRNA-372 (miR-372) is downregulated in human PCa and inhibits the proliferation activity, migration, and invasion of DU145 cells. Subsequently, p65 is confirmed as a target of miR-372, and knockdown of p65 expression similarly resulted in decreased proliferation activity, migration, and invasion. CDK8, MMP-9, and prostate-specific antigen were involved in both these processes. Taken together, our results show evidence that miR-372 may function as a tumor suppressor gene by regulating p65 in PCa and may provide a strategy for blocking PCa metastasis.

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“…HBx from HBV seems in charge of HULC upregulation and HULC silencing blocks HBx protein-mediated enhanced cell proliferation (Du et al, 2012; Wang et al, 2010). Interestingly, HULC sequesters miR-372, involved in regulation of cell cycle, apoptosis, invasion, and proliferation in many types of human cancers (Wu et al, 2015). …”

Section: Viruses and Lncrnasmentioning

confidence: 99%

Long noncoding RNAs in viral infections

2016

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Viral infections induce strong modifications in the cell transcriptome. Among the RNAs whose expression is altered by infection are long noncoding RNAs (lncRNAs). LncRNAs are transcripts with potential to function as RNA molecules. Infected cells may express viral lncRNAs, cellular lncRNAs and chimeric lncRNAs formed by viral and cellular sequences. Some viruses express viral lncRNAs whose function is essential for viral viability. They are transcribed by polymerase II or III and some of them can be processed by unique maturation steps performed by host cell machineries. Some viral lncRNAs control transcription, stability or translation of cellular and viral genes. Surprisingly, similar functions can be exerted by cellular lncRNAs induced by infection. Expression of cellular lncRNAs may be altered in response to viral replication or viral protein expression. However, many cellular lncRNAs respond to the antiviral pathways induced by infection. In fact, many lncRNAs function as positive or negative regulators of the innate antiviral response. Our current knowledge about the identity and function of lncRNAs in infected cells is very limited. However, research into this field has already helped in the identification of novel cellular pathways and may help in the development of therapeutic tools for the treatment of viral infections, autoimmune diseases, neurological disorders and cancer.

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Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma

Cited by 35 publications

References 28 publications

The E2F1–miR-520/372/373–SPOP Axis Modulates Progression of Renal Carcinoma

The E2F1–miR-520/372/373–SPOP Axis Modulates Progression of Renal Carcinoma

microRNA-372 Suppresses Migration and Invasion by Targeting p65 in Human Prostate Cancer Cells

Long noncoding RNAs in viral infections

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