2015
DOI: 10.1080/15384047.2015.1046024
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Low miR-145 silenced by DNA methylation promotes NSCLC cell proliferation, migration and invasion by targeting mucin 1

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Cited by 25 publications
(19 citation statements)
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“…Lu et al (18) showed that miR-145 inhibited the migration and invasion of glioma cells via direct inhibition of ADAM17 expression. Zhang et al (19) reported that miR-145 suppressed the invasion and metastasis Only few studies have focused on the underlying molecular mechanism of the involvement of miR-145 in the development and progression of NSCLC (20). The present study identified one of its targets, FSCN1, which is involved in the miR-145-mediated downregulation of NSCLC cell migration and invasion.…”
Section: A B Discussionmentioning
confidence: 59%
“…Lu et al (18) showed that miR-145 inhibited the migration and invasion of glioma cells via direct inhibition of ADAM17 expression. Zhang et al (19) reported that miR-145 suppressed the invasion and metastasis Only few studies have focused on the underlying molecular mechanism of the involvement of miR-145 in the development and progression of NSCLC (20). The present study identified one of its targets, FSCN1, which is involved in the miR-145-mediated downregulation of NSCLC cell migration and invasion.…”
Section: A B Discussionmentioning
confidence: 59%
“…miR-145 inhibits migration and invasion by downregulating FSCN1 (17) and mucin1 (18). A previous study by the present authors revealed that miR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer (33).…”
Section: Discussionmentioning
confidence: 99%
“…miR-145 regulates chemoresistance in hepatocellular carcinoma (15) and bladder cancer (16) via EMT. miR-145 inhibits migration and invasion by down-regulating fascin actin-bundling protein 1 (FSCN1) (17) and mucin 1 (18).…”
Section: Introductionmentioning
confidence: 99%
“…36 In NSCLC, miR-145-5p has been reported to be downregulated and to exert tumor-suppressor functions. Some targets of miR-145-5p in NSCLC have been reported, such as c-Myc, 37 mucin 1, 38 and FSCN1. 39 Despite these discoveries, the precise molecular mechanisms of miRNA-145-5p in NSCLC remain largely unknown and require further exploration.…”
Section: Introductionmentioning
confidence: 99%