Low Maternal Vitamin B12 Status Is Associated with Lower Cord Blood HDL Cholesterol in White Caucasians Living in the UK

Adaikalakoteswari, Antonysunil; Vatish, Manu; Lawson, Alexander J.; Wood, Catherine; Sivakumar, Kothandam; McTernan, P. G.; Webster, Craig; Anderson, N.V.; Yajnik, Chittaranjan S.; Tripathi, Gyanendra; Saravanan, Ponnusamy

doi:10.3390/nu7042401

Cited by 40 publications

(44 citation statements)

References 35 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding maternal folic acid, we observed only 3.2% folate deficiency in the total population, while Adaikalakoteswari et al [32] reported 11% folate deficiency in their study on 91 pregnant women and their neonates. Moreover, maternal serum folic acid level showed insignificant differences between group A and B (9.57 ± 3.63 vs. 9.1 ± 2.73 respectively, P = 0.27), which contradicts other previous studies as [12] [36] [43].…”

Section: Discussioncontrasting

confidence: 74%

“…Worldwide the prevalence of maternal vitamin B12 insufficiency is different in many studies, 59%, in Venezuela [30], 46% in South Korea [31], 40% in UK [32], 36.5% in Turkey [33], and 8% in Sudan [34]. Recently Sukumar et al [7] reported that the pooled estimate of maternal vitamin B12 insufficiency during pregnancy across all three trimesters were 21%, 19%, and 29% respectively.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Youssry¹,

Radwan²,

Gebreel³

et al. 2017

OJOG

View full text Add to dashboard Cite

Objective: The aim of this study is to evaluate vitamin B12, folate, and homocysteine status in pregnant women in the third trimester of pregnancy and their relationship to fetal birth weight and their correlation to corresponding neonatal cord blood levels, and in addition, to evaluate the possibility of maternal serum homocysteine level as a predictor of low birth weight infants. Subjects and Methods: In this cross-sectional study, a total of two hundred pregnant women in third trimester (≥28 weeks) were recruited. After a detailed obstetrical and medical history, and clinical assessment, participants were subdivided into two groups: Group (A)-pregnant women who delivered average birth weight (ABW) infants and Group (B) for those who delivered low birth weight (LBW) infants between completed 37 and 42 weeks. Results: Vitamin B12 deficiency was observed in 24.1% of the total cohort. The mean vitamin B12 level was significantly lower in group (B) compared to group (A) (195.2 ± 38.9 vs. 225.9 ± 66.59 respectively P = 0.008). The mean level of homocysteine for women in group (B) was significantly higher than those determined from women in group (A) (9.10 ± 5.9 vs. 7.6 ± 3.83 respectively, P = 0.042). On the other hand, the mean folate levels showed statistically insignificant differences between both groups. The mean cord vitamin B12 level was significantly lower in LBW infants in comparison to ABW infants (277 ± 61.93 vs. 312.03 ± 81.87 respectively, P = 0.015), while the mean level of cord homocysteine for LBW infants was significantly higher than those levels determined from ABW infants (7.9 ± 3.79 vs. 6.6 ± 2.09 respec- deficiency could be significant risk for LBW infants. Hyperhomocysteinemia has been shown to be a predictor for adverse pregnancy outcomes particularly LBW.

show abstract

Section: Discussioncontrasting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Youssry¹,

Radwan²,

Gebreel³

et al. 2017

OJOG

View full text Add to dashboard Cite

show abstract

“…In addition, suboptimal vitamin B-12 concentrations in pregnancy have been shown to be independently associated with low birth weight (LBW) (17), an adverse lipid profile in neonates (18), and higher insulin resistance in children (19). LBW or small-for-gestational age (SGA) are outcomes of particular interest because they are well-established surrogate markers for metabolic disorders such as obesity, type 2 diabetes, and metabolic syndrome in later life in many populations (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Sukumar

Rafnsson

Kandala

et al. 2016

The American Journal of Clinical Nutrition

Self Cite

View full text Add to dashboard Cite

Background: Vitamin B-12 and folate are micronutrients essential for normal embryogenesis. Vitamin B-12 insufficiency in pregnancy is high in certain parts of the world, such as India, and although this has been linked to low birth weight (LBW) in these populations, the relation between vitamin B-12 and birth weight (BW) elsewhere is unknown. Objectives: We performed a systematic review to assess 1) the worldwide prevalence of vitamin B-12 insufficiency in pregnancy and 2) its association with BW. Design: A search of 5 electronic databases was performed to identify eligible articles. Random-effects meta-analysis was conducted according to geographic regions and pregnancy trimesters for the prevalence subreview and by categorical measures of BW. Results: A total of 57 and 23 articles were included for the prevalence and BW subreviews, respectively. The pooled estimates of vitamin B-12 insufficiency were 21%, 19%, and 29% in the first, second, and third trimesters, respectively, with high rates for the Indian subcontinent and the Eastern Mediterranean. The large heterogeneity between studies was partially addressed by creating a standardized score for each study (mean vitamin B-12 insufficiency O cutoff value), which internally corrected for geographic region, trimester, and assay type. Twelve of the 13 longitudinal studies included showed a decrease in mean or median vitamin B-12 across trimesters. Pooled analysis showed nonsignificantly lower maternal vitamin B-12 concentrations in LBW than in normal-BW infants and higher odds of LBW with lower vitamin B-12 values (adjusted OR: 1.70; 95% CI: 1.16, 2.50), but studies from India largely contributed to the latter. Conclusions: Our review indicates that vitamin B-12 insufficiency during pregnancy is common even in nonvegetarian populations and that concentrations of vitamin B-12 decrease from the first to the third trimester. There is no consistent association between vitamin B-12 insufficiency and LBW. However, given the long-term risks of LBW, this observation warrants further cohort studies and randomized controlled trials.Am J Clin Nutr 2016;103:1232-51.

show abstract

“…Of the remaining 95 papers, 63 were excluded on the basis of the full text. The remaining 32 articles are included in this review, as shown in Supplemental S1 (Adaikalakoteswari et al, ; Ambroszkiewicz, Chelchowska, Lewandowski, Gajewska, & Laskowska‐Klita, ; Baker et al, ; Bakker et al, ; Bergen et al, ; Bodnar et al, ; Coker et al, ; Dayaldasani et al, ; Frery et al, ; D. Furness et al, ; D. L. Furness, Yasin, Dekker, Thompson, & Roberts, ; Gadowsky et al, ; Hay et al, ; Jauniaux, Johns, Gulbis, Spasic‐Boskovic, & Burton, ; Knight et al, ; Knudtson et al, ; Larroque et al, ; Matsuzaki et al, ; McDonald, Perkins, Jodouin, & Walker, ; Mito et al, ; Nilsen et al, ; Ozerol, Ozerol, Gokdeniz, Temel, & Akyol, ; Pagan, Hou, Goldenberg, Cliver, & Tamura, ; Prasodjo et al, ; Relton et al, ; Sram, Binkova, Lnenickova, Solansky, & Dejmek, ; Stark et al, ; Stark, Pawlosky, Sokol, Hannigan, & Salem Jr., ; Van Uitert et al, ; van Wersch, Janssens, & Zandvoort, ; Vandevijvere, Amsalkhir, Van Oyen, & Moreno‐Reyes, ; Yila et al, ).…”

Section: Resultsmentioning

confidence: 99%

Folate, vitamin B12, and homocysteine in smoking‐exposed pregnant women: A systematic review

Tuenter

Bautista-Niño

Vitezova

et al. 2018

Maternal & Child Nutrition

View full text Add to dashboard Cite

Smoking exposure is associated with pregnancy complications, as are levels of folate, vitamin B12, and homocysteine. In nonpregnant adults, smoking exposure is associated negatively with folate and vitamin B12 levels and positively with homocysteine levels. A complete overview of the literature on this topic in pregnant women is lacking. To evaluate evidence of associations of maternal smoking exposure during pregnancy and levels of folate, homocysteine, and vitamin B12 in pregnancy and in cord blood, we searched MEDLINE, Embase, CINAHL, Cochrane, Scopus, Web of Science, and reference lists of relevant studies until August 2017. We selected studies in pregnant women describing the association of passive or active smoking and levels of folate, homocysteine, and/or vitamin B12. Data were extracted by two independent reviewers. We included 32 studies of 2,015 identified references with a total of 37,822 participants and more than 6,000 smokers. Twenty-eight studies measured folate, 14 measured vitamin B12, and 13 measured homocysteine. Nineteen out of 28 studies assessing folate reported significantly lower levels in pregnant women exposed to smoking compared with those unexposed. Vitamin B12 levels were lower in smoking mothers in eight out of 14 studies. Homocysteine levels tended to be higher in mothers exposed to smoking. Smoking exposure during pregnancy is generally associated with lower folate and vitamin B12 levels and higher homocysteine levels. This may help raise further awareness about the consequences of smoking and the need to encourage stopping smoking in all, especially in pregnant women.

show abstract

Low Maternal Vitamin B12 Status Is Associated with Lower Cord Blood HDL Cholesterol in White Caucasians Living in the UK

Cited by 40 publications

References 35 publications

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Folate, vitamin B12, and homocysteine in smoking‐exposed pregnant women: A systematic review

Contact Info

Product

Resources

About