Low-magnitude high-frequency vibration enhances gene expression related to callus formation, mineralization and remodeling during osteoporotic fracture healing in rats

Chung, Shu-Lu; Leung, Kwok‐Sui; Cheung, Wing-Hoi

doi:10.1002/jor.22715

Cited by 44 publications

(78 citation statements)

References 28 publications

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“…Ten (Butezloff et al, 2015;Cheung et al, 2012;Chow et al, 2011;Chung et al, 2014;Leung et al, 2009;Shi et al, 2010;Wehrle et al, 2015;Wehrle et al, 2014;Wei et al, 2016) of the nineteen studies adopt a 20 min/d treatment, four (Bilgin et al, 2017;Komrakova et al, 2013;Stuermer et al, 2014;Stuermer et al, 2010) In this review, vibration regimes with a magnitude lower than 1 ×g were regarded as LMHFV and those with a magnitude greater than 1 ×g were regarded as HMHFV (high magnitude high frequency vibration). Six (Butezloff et al, 2015;Komrakova et al, 2016;Komrakova et al, 2013;Stuermer et al, 2014;Stuermer et al, 2010;Usui et al, 1989) of the included studies use HMHFV and twelve (Bilgin et al, 2017;Cheung et al, 2012;Chow et al, 2011;Chung et al, 2014;Gao et al, 2016;Leung et al, 2009;Shi et al, 2010;Wehrle et al, 2015;Wehrle et al, 2014;Wolf et al, 2001) adopt LMHFV. One study uses both LMHFV and HMHFV (Uchida et al, 2017).…”

Section: Search Criteriamentioning

confidence: 98%

“…Exclusion criteria were: 1) non-English-language papers; 2) not vibration treatment-related; 3) not Cheung et al, 2012;Chow et al, 2011;Chung et al, 2014;Gao et al, 2016;Komrakova et al, 2016;Komrakova et al, 2013;Leung et al, 2009;Shi et al, 2010;Stuermer et al, 2014;Stuermer et al, 2010;Uchida et al, 2017;Wei et al, 2016), two mouse studies (Wehrle et al, 2015;Wehrle et al, 2014), one sheep study (Wolf et al, 2001) and one rabbit study (Usui et al, 1989). No clinical study was found, based on our search criteria on publications prior to the 12 th March 2017.…”

Section: Search Criteriamentioning

confidence: 99%

“…Among the fifteen rat studies, one uses males (Bilgin et al, 2017). Among the other fourteen studies on female rats, five (Chow et al, 2011;Komrakova et al, 2016;Komrakova et al, 2013;Stuermer et al, 2014;Wei et al, 2016) report vibration treatment on ovariectomised (OVX) rats, five (Butezloff et al, 2015;Cheung et al, 2012;Chung et al, 2014;Shi et al, 2010) apply vibration to both OVX and sham-OVX models and one to both OVX and non-OVX rats (Stuermer et al, 2010). Three studies (Gao et al, 2016;Leung et al, 2009;Uchida et al, 2017) use only non-OVX rats as research subjects.…”

Section: Search Criteriamentioning

confidence: 99%

“…Nine of them use closed fracture models with Kirschner wire (K-wire) internal fixation; of those, eight are carried out on the femur of the animals (Butezloff et al, 2015;Cheung et al, 2012;Chow et al, 2011;Chung et al, 2014;Leung et al, 2009;Shi et al, 2010;Wei et al, 2016) and one uses the tibia fracture model (Gao et al, 2016). The other ten studies include two femoral fracture models (Wehrle et al, 2015;Wehrle et al, 2014), five tibial fracture models (Bilgin et al, 2017;Komrakova et al, 2016;Komrakova et al, 2013;Stuermer et al, 2014;Stuermer et al, 2010), one metatarsal fracture model [in which researchers conducted osteotomy with external fixators or titanium plates (Wolf et al, 2001)], one rib fracture model without fixation (Uchida et al, 2017) and one fibular osteotomy model without fixation (Usui et al, 1989).…”

Section: Search Criteriamentioning

confidence: 99%

“…Other bone Cheung et al, 2012;Chow et al, 2011;Chung et al, 2014;Leung et al, 2009;Shi et al, 2010;Wehrle et al, 2015;Wei et al, 2016) of which show positive effects on fracture healing. Usui et al (1989) [HMHFV, 25 Hz, two dimensional, 1.7 ×g (horizontal), 2.0 ×g (vertical), open fracture, rabbit] report on both 20 and 60 min/d two-dimensional vibration treatment during fracture healing.…”

Section: Search Criteriamentioning

confidence: 99%

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The effect of whole body vibration on fracture healing – a systematic review

Wang¹,

Leung²,

Chow³

et al. 2017

eCM

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This systematic review examines the efficacy and safety of whole body vibration (WBV) on fracture healing. A systematic literature search was conducted with relevant keywords in PubMed and Embase, independently, by two reviewers. Original animal and clinical studies about WBV effects on fracture healing with available full-text and written in English were included. Information was extracted from the included studies for review. In total, 19 articles about pre-clinical studies were selected. Various vibration regimes are reported; of those, the frequencies of 35 Hz and 50 Hz show better results than others. Most of the studies show positive effects on fracture healing after vibration treatment and the responses to vibration are better in ovariectomised (OVX) animals than non-OVX ones. However, several studies provide insufficient evidence to support an improvement of fracture healing after vibration and one study even reports disruption of fracture healing after vibration. In three studies, vibration results in positive effects on angiogenesis at the fracture site and surrounding muscles during fracture healing. No serious complications or side effects of vibration are found in these studies. WBV is suggested to be beneficial in improving fracture healing in animals without safety problem reported. In order to apply vibration on fractured patients, more well-designed randomised controlled clinical trials are needed to examine its efficacy, regimes and safety. Keywords THE EFFECT OF WHOLE BODY VIBRATION ON FRACTURE HEALING -A SYSTEMATIC REVIEW IntroductionFracture is a common musculoskeletal problem with high morbidity. Most fractures usually heal uneventfully well, but about 5-10 % of the fractures result in impaired healing, such as delayed union and non-union (Rozen et al., 2007). Therefore, it is of great importance to develop more efficient management to minimise delayed union and nonunion. Fracture healing is a complicated biological process that consists of an inflammatory stage, repair stage and remodelling stage (Kalfas, 2001). The healing process can be influenced by various factors, of which biomechanical condition at the fracture site is considered as one of the key determinants (Einhorn, 1998;Hannouche et al., 2001 et al., 2014). Some studies provide evidence that WBV has effects on the musculoskeletal system, including improving muscle function (Rees et al., 2008;Sitja-Rabert et al., 2015), increasing bone mineral density (BMD) (Lam et al., 2013;Verschueren et al., 2004), reducing risks of falls and improving muscle strength and balancing ability . Low-magnitude high-frequency vibration (LMHFV), a type of WBV with magnitude usually lower than 1 ×g [magnitude, in gravitational acceleration (m/s2 )] and frequency ranged from 20 to 90 Hz (Bemben et al., 2010;Fuermaier et al., 2014;von Stengel et al., 2011), is also reported to have positive effects on osteogenic differentiation and osteogenesis (Dumas et al., 2010;Kim et al., 2012;Leung et al., 2014;Luu et al., 2009). Some previous studies usi...

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Section: Search Criteriamentioning

confidence: 98%

Section: Search Criteriamentioning

confidence: 99%

Section: Search Criteriamentioning

confidence: 99%

Section: Search Criteriamentioning

confidence: 99%

Section: Search Criteriamentioning

confidence: 99%

See 3 more Smart Citations

The effect of whole body vibration on fracture healing – a systematic review

Wang¹,

Leung²,

Chow³

et al. 2017

eCM

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Vibration in mice: A review of comparative effects and use in translational research

Reynolds

Garner

et al. 2018

Anim Models and Exp Med

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Sound pressure waves surround individuals in everyday life and are perceived by animals and humans primarily through sound or vibration. When sound pressure waves traverse through a solid medium, vibration will result. Vibration has long been considered an unwanted variable in animal research and may confound scientific endeavors using animals. Understanding the characteristics of vibration is required to determine whether effects in animals are likely to be therapeutic or result in adverse biological effects. The eighth edition of the "Guide for the Care and Use of Laboratory Animals" highlights the importance of considering vibration and its effects on animals in the research setting, but knowledge of the level of vibration for eliciting these effects was unknown. The literature provides information regarding therapeutic use of vibration in humans, but the range of conditions to be of therapeutic benefit is varied and without clarity. Understanding the characteristics of vibration (eg, frequency and magnitude) necessary to cause various effects will ultimately assist in the evaluation of this environmental factor and its role on a number of potential therapeutic regimens for use in humans. This paper will review the principles of vibration, sources within a research setting, comparative physiological effects in various species, and the relative potential use of vibration in the mouse as a translational research model. K E Y W O R D Sanimal models, mice, translational, vibration

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Vibration and β‐hydroxy‐β‐methylbutyrate treatment suppresses intramuscular fat infiltration and adipogenic differentiation in sarcopenic mice

Wang

Cui

Chim

et al. 2020

J cachexia sarcopenia muscle

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Background Sarcopenia is an aging-induced deterioration of skeletal muscle mass and function. Low-magnitude highfrequency vibration (LMHFV) was shown to improve muscle functions and β-hydroxy-β-methylbutyrate (HMB) to increase muscle mass and strength. Muscle-derived stem cells (MDSCs) are progenitor cells important for muscle regeneration. We hypothesized that LMHFV and HMB could retard sarcopenia by reducing fat infiltration through inhibiting adipogenesis in MDSCs. Methods Senescence-accelerated mouse P8 male mice were randomized into control (CTL), HMB, LMHFV (VIB), and combined (COM) groups. Interventions started at age of month 7 and assessed at 1, 2, and 3 months post-intervention by densitometry, histology, and functional tests. In vitro, MDSCs isolated from gastrocnemius of senescence-accelerated mouse P8 mice were characterized, randomized into CTL, VIB, HMB, and COM groups, and assessed by oil red O staining, mRNA, and protein expression.Results At 2 months post-intervention, percentage lean mass of HMB, VIB, and COM groups were significantly higher than CTL group. Twitch, tetanic, and specific tetanic forces of COM group were higher, while specific twitch force of both VIB and COM groups were higher. Grip strength of HMB, VIB, and COM groups were higher. Histologically, both VIB and COM groups presented lower oil red O area than CTL group. Type I muscle fibre in CTL group was higher than HMB, VIB, and COM groups. MDSC were detected in situ by immunofluorescence stain with stem cell antigen-1 signals confirmed with higher β-catenin expression in the COM group. The observations were also confirmed in vitro, MDSCs in the HMB, VIB, and COM groups presented lower adipogenesis vs. the CTL group. β-Catenin mRNA and protein expressions were lower in the CTL group while their relationship was further validated through β-catenin knock-down approach.Conclusions Our results showed that combined LMHFV and HMB interventions enhanced muscle strength and decreased percentage fat mass and intramuscular fat infiltration as compared with either treatment alone. Additive effect of LMHFV and HMB was demonstrated in β-catenin expression than either treatment in MDSCs and altered cell fate from adipogenesis to myogenesis, leading to inhibition of intramuscular lipid accumulation. Wnt/β-catenin signalling pathway was found to be the predominant regulatory mechanism through which LMHFV and HMB combined treatment suppressed MDSCs adipogenesis.

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Low-magnitude high-frequency vibration enhances gene expression related to callus formation, mineralization and remodeling during osteoporotic fracture healing in rats

Cited by 44 publications

References 28 publications

The effect of whole body vibration on fracture healing – a systematic review

The effect of whole body vibration on fracture healing – a systematic review

Vibration in mice: A review of comparative effects and use in translational research

Vibration and β‐hydroxy‐β‐methylbutyrate treatment suppresses intramuscular fat infiltration and adipogenic differentiation in sarcopenic mice

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