Low magnesium level as an indicator of poor glycemic control in type 2 diabetic patients with complications

Joy, Salini Scaria; George, Teena P.; Siddiqui, Khalid

doi:10.1016/j.dsx.2019.02.001

Cited by 21 publications

(14 citation statements)

References 20 publications

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“…Magnesium ions are involved in carbohydrate metabolism and insulin response, whereas magnesium deficiency is reportedly related to endocrine and metabolic disorders [ 70 , 71 , 72 ]. An inverse relationship exists between serum magnesium and fasting glucose or glycated hemoglobin levels [ 73 ]. In addition, lower serum magnesium levels are observed in patients with diabetic neuropathy [ 74 ], correlated with diabetic macro- and microvascular complications [ 73 , 75 ].…”

Section: Other Acute and Chronic Painmentioning

confidence: 99%

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Magnesium and Pain

Shin

Hwan

2020

Nutrients

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In terms of antinociceptive action, the main mode of action of magnesium involves its antagonist action at the N-methyl-d-aspartate (NMDA) receptor, which prevents central sensitization and attenuates preexisting pain hypersensitivity. Given the pivotal function of NMDA receptors in pain transduction, magnesium has been investigated in a variety of pain conditions. The oral and parenteral administration of magnesium via the intravenous, intrathecal, or epidural route may alleviate pain and perioperative anesthetic and analgesic requirements. These beneficial effects of magnesium therapy have also been reported in patients with neuropathic pain, such as malignancy-related neurologic symptoms, diabetic neuropathy, postherpetic neuralgia, and chemotherapy-induced peripheral neuropathy. In addition, magnesium treatment is reportedly able to alleviate fibromyalgia, dysmenorrhea, headaches, and acute migraine attacks. Although magnesium plays an evolving role in pain management, better understanding of the mechanism underlying its antinociceptive action and additional clinical studies is required to clarify its role as an adjuvant analgesic.

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Section: Other Acute and Chronic Painmentioning

confidence: 99%

“…An inverse relationship exists between serum magnesium and fasting glucose or glycated hemoglobin levels [ 73 ]. In addition, lower serum magnesium levels are observed in patients with diabetic neuropathy [ 74 ], correlated with diabetic macro- and microvascular complications [ 73 , 75 ].…”

Section: Other Acute and Chronic Painmentioning

confidence: 99%

Magnesium and Pain

Shin

Hwan

2020

Nutrients

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“…Several non-communicable diseases have been associated with alterations in the levels of some minerals, among them low magnesium levels. Evidence has suggested that magnesium depletion may play an essential role in the pathophysiology of diabetes mellitus, hypertension, obesity, and dyslipidemia (6,(11)(12)(13). In this context, there is a biological plausibility to associate hypomagnesemia with metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Serum magnesium levels in relation to metabolic syndrome: A national population-based cross-sectional study from Jordan

Addin¹,

Batieha²,

Khader³

et al. 2021

Preprint

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Background/Aims: Individuals with metabolic syndrome are at higher risk to develop cardiovascular disease, diabetes type 2, and certain types of cancers such as pancreatic, liver, and colorectal cancers. Studies suggest a potential association between hypomagnesemia and metabolic syndrome with conflicting results. The present study aims to estimate the prevalence of metabolic syndrome and its components in Jordan and to further explore the association between low magnesium levels and metabolic syndrome and its components. Methods Data were derived from the national population-based household survey conducted in Jordan in 2009. The study was multipurpose and collected a wide array of data including interview data, anthropometric measurements, and laboratory data. The present report deals, exclusively, with subjects aged ≥ 20 years. There was a total of 4,520 subjects (1113 men and 3407 women). Results We found alarmingly high prevalence rates of metabolic syndrome and its components defined by IDF (international diabetic federation) criteria (39.8%) with the highest burden being among women (40.7% in women and 37.4% in men). Among metabolic syndrome components, central obesity and low HDL were the most commonly occurring components of metabolic syndrome (62.6% and 65.5%, respectively). We observed a significant inverse association between serum magnesium levels and metabolic syndrome after adjusting for age (OR = 1.57, p value = 0.048). Among metabolic syndrome components, low serum magnesium levels were significantly associated with low serum HDL levels (OR = 2.15, p value = 0.001). Conclusion Metabolic syndrome prevalence in Jordan is considerably high. Our findings suggest that serum magnesium levels are inversely associated with metabolic syndrome.

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“…Diabetin komplikasyonlarından olan santral ve periferik nöropatiye, hipoglisemi ve hipergliseminin kadar, serum ve hücre içi magnezyum (Mg) düzeyi düşüklüğünün de neden olabileceği bildirilmiştir (8). Mg eksikliğinin başta adenilsiklaz olmak üzere pek çok enzimin aktivitesinde azalmaya, inositolün transmembran transportunda yavaşlamaya, intrasellüler sorbitol birikimine, inositol azalması ile Na-K ATPaz enzim aktivitesinde inhibisyona yol açmaktadır.…”

Section: Introductionunclassified

Tip 1 Diabetes Mellituslu Çocuklarda Uyarılmış Potansiyellerin Eş Zamanlı Kan Şekeri, Serum ve Hücre İçi Magnezyum Düzeyleri ve Glikozillenmiş Hemoglobin İle İlişkisi

Karal¹,

Karasalihoğlu²,

Turgut³

et al. 2020

Osmangazi̇ Journal of Medicine

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Özet: Tip I Diabetes Mellitus çocukluk çağının ciddi komplikasyonlar ile seyreden kronik metabolik hastalıklarından biridir. Bu çalışmanın amacı Tip I Diabetes Mellituslu çocuklarda erken dönemde santral sinir sistemi tutulumunun uyarılmış potansiyeller aracılığıyla değerlendirilmesi ve metabolik değişikliklerle ilişkisini saptamaktır. Çalışmaya 5-14 yaş arasında 31 Tip I Diabetes Mellituslu ve aynı yaş ve cinsiyette 35 sağlam çocuk alındı. Olgulardan 8 saat açlık sonrası HbA1c, kan şekeri, serum ve hücre içi magnezyum düzeyleri için kan örnekleri alındı. Tüm olguların otoskopik muayeneleri, işitme testleri ve uyarılmış potansiyel ölçümleri yapıldı. Gruplar metabolik parametreler, diabet süresi ve uyarılmış potansiyeller açısından karşılaştırıldı. Çalışma grubunun HbA1c ve kan şekeri değerleri kontrol grubuna göre anlamlı düzeyde yüksek, serum Mg değerleri istatistiksel olarak anlamlı oranda düşük saptandı (p<0.001) Diabetik grubun görsel uyarılmış potansiyelleri ve işitsel uyarılmış potansiyellerinin anlamlı oranda bozulduğu saptandı (p<0.05). Her iki grup arasında duyusal uyarılmış potansiyel değerlerinde belirgin farklılık gözlenmedi (p>0.05). Diabetik gruptaki tüm bu etkilenmelerin serum ve hücre içi magnezyumu, eş zamanlı kan şekeri, diabet süresi ve HbA1c düzeyleri ile ilişkili olduğu bulundu (p<0.05). Çalışmamızda diabette santral sinir sistemi tutulumu uyarılmış potansiyeller aracılığı ile gösterilebilen en erken bulgu olabileceği saptanmıştır. Bu etkilenmenin nedenleri arasında eş zamanlı kan şekeri ve diabetin süresi kadar glikozillenmiş hemoglobin, serum ve hücre içi magnezyum düzeyleri önemli de önemli yer tutmaktadır. Bu nedenle uyarılmış potansiyeller ve kan magnezyum düzeyi ölçümlerinin HbA1c, kan şekeri ölçümlerinde olduğu gibi diabetin rutin takip programına alınması yararlı olacaktır.

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Low magnesium level as an indicator of poor glycemic control in type 2 diabetic patients with complications

Cited by 21 publications

References 20 publications

Magnesium and Pain

Magnesium and Pain

Serum magnesium levels in relation to metabolic syndrome: A national population-based cross-sectional study from Jordan

Tip 1 Diabetes Mellituslu Çocuklarda Uyarılmış Potansiyellerin Eş Zamanlı Kan Şekeri, Serum ve Hücre İçi Magnezyum Düzeyleri ve Glikozillenmiş Hemoglobin İle İlişkisi

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