Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients

Polack, Edith; Nahmod, Víctor E.; Emeric-Sauval, Estela; Bello, Mabel; Costas, Mónica Alejandra; Finkielman, Samuel; Arzt, Eduardo

doi:10.1007/bf00920020

Cited by 52 publications

(35 citation statements)

References 27 publications

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“…Regarding cytokine production in AN patients, variable results have also been reported from studies carried out with very different designs. An inhibition of PHA-induced IFN-g production by peripheral blood mononuclear cells (PBMCs) of AN patients in relation to that of age-matched controls has been found previously (Schattner et al, 1990b;Polack et al, 1993), which could be related to an impaired response of the immune system against pathogens.…”

Section: Anorexia Nervosa As An Example Of Malnutrition In Industrialmentioning

confidence: 64%

“…Although it is difficult to establish how this cytokine modulation by yoghurt intake may influence the immune system of the anorexic patients, some benefits could be presumed from this stimulation since previous results have pointed to an apparent inhibition of PHA-induced IFN-g production by PBMCs in AN patients in relation to that of age-matched controls (Schattner et al, 1990;Polack et al, 1993). However, it is also difficult to know if the response in vivo against a pathogen would be similar to the one observed in vitro against the mitogen.…”

Section: Discussionmentioning

confidence: 99%

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The effect of fermented milk on interferon production in malnourished children and in anorexia nervosa patients undergoing nutritional care

et al. 2002

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For several years cytokine production has been associated with infections but it was not suspected that some types of food could also induce cytokines, even in a state of non-infection. Lactic bacteria can induce interferon (IFN) production in human healthy subjects, thus, a better protection against infections would be expected. Therefore, we planned to evaluate the effect of two diets including yoghurt or milk on IFN-g production during nutritional recovery in two different situations of malnutrition: (1) children with diarrhoea; and (2) patients with anorexia nervosa (AN). Both the diet including yoghurt of that including milk seemed to increase IFN-g production at the end of nutritional recovery in the malnourished children with diarrhoea. The significance of interferon production and the lymphocyte subset increase should be explored to know if a better resistance against pathogens is related to them. Regulation of intestinal absorption and moderate stimulation of interferon production make the yoghurt-based diet a good choice in the nutritional care of children. In the same way, an increase in the IFN-g production was observed in AN patients consuming yoghurt. This increase of IFN-g production could be considered a biological marker to detect the effect of probiotics on the immune response, especially in the improvement of a deficient nutritional status.

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Section: Anorexia Nervosa As An Example Of Malnutrition In Industrialmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

The effect of fermented milk on interferon production in malnourished children and in anorexia nervosa patients undergoing nutritional care

et al. 2002

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“…However, it is evident that not all AN patients display the same changes in immune function and cytokine production . A variable lymphocyte proliferative response to different mitogens has been reported in anorectic subjects (Polack et al, 1993). Different results for cytokine production by peripheral blood mononuclear cells (PBMCs) have also been reported.…”

Section: Relationship Between Eating Disorders and The Neuroendocrinementioning

confidence: 99%

Malnutrition and Inflammation

Mujico¹,

Pérez-de-Heredia²,

Gómez‐Martínez³

et al. 2012

Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases

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“…In humans transient reduction of circulating T lymphocytes has been reported in patients submitted to fasting with therapeutic proposal 12 . However, either an increased, a reduction or no alterations in T-dependent immune responses has been reported in patients with nervous anorexia 13 .…”

Section: Introductionmentioning

confidence: 99%

Effects of short term fasting on the evolution of fecal peritonitis in mice

Bermudes¹,

Dettoni

Pereira³

2011

Acta Cir. Bras.

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Purpose:To investigate the effect of 72 hours food suppression on the evolution of fecal peritonitis in mice evaluating the mortality and measuring the number and size of abscesses formed into the peritoneal cavity. Methods: Mice receiving commercial diet and water ad libitum (control group, N=35) and mice fasted during 72 h (N=35), receiving only water ad libitum, were inoculated by i.p. route, with 4uL/g body weight of a fecal suspension diluted 1:6 or 1:9 in 0.15M NaCl solution (1:6 dilution, 22 controls and 18 fasted; 1:9 dilution, 13 controls and 17 fasted). Animals were followed up until two weeks after fecal inoculation, when the survivors were euthanized for evaluation of the number and size of intra-peritoneal abscesses. Mortality was evaluated by Kaplan Meyer curves. Results: Mortality was significantly higher in fasted groups than in controls. However the number and size of abscesses were significantly less in fasted groups than in controls. Conclusion: Seventy two hours food suppression increased the susceptibility to endotoxic shock (high mortality after peritonitis induction) and the resistance to infection with fecal microorganisms (less number and size of intra-peritoneal abscesses). Key words: Fasting. Peritonitis. Shock, Septic. Mice. RESUMOObjetivo: Investigar o efeito de jejum de 72 horas na evolução de peritonite fecal em camundongos, avaliando a mortalidade e o número e tamanho dos abscessos formados na cavidade peritoneal. Métodos: Camundongos recebendo dieta ad libitum (grupo controle, N=35) e camundongos submetidos a jejum durante 72h (N=35) foram inoculados, por via intraperitoenal, com 4uL/g de peso corporal de uma suspensão de fezes diluída a 1:6 ou 1:9 em NaCl 15M (diluição 1:6, 22 controles e 18 jejum; diluição 1:9, 13 controles e 17 jejum). Os animais foram acompanhados até duas semanas após a inoculação das fezes quando eram eutanaziados para avaliação do número e tamanho dos abscessos intraperitoneais. A mortalidade foi avaliada através das curvas de Kaplan Meyer. Resultados: A mortalidade foi significativamente maior nos animais submetidos ao jejum. No entanto o número e tamanho dos abscessos foram significativamente menores neste grupo. Conclusão: O jejum de 72 horas aumentou a susceptibilidade ao choque endotóxico (maior mortalidade nas primeiras 48 horas) e aumento da resistência aos microorganismos fecais (menor número e tamanho dos abscessos intraperitoneais). Descritores: Jejum. Peritonite. Choque Séptico. Camundongos. -Acta Cirúrgica Brasileira -Vol. 26 (3) 2011Pereira FEL et al.

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Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients

Cited by 52 publications

References 27 publications

The effect of fermented milk on interferon production in malnourished children and in anorexia nervosa patients undergoing nutritional care

The effect of fermented milk on interferon production in malnourished children and in anorexia nervosa patients undergoing nutritional care

Malnutrition and Inflammation

Effects of short term fasting on the evolution of fecal peritonitis in mice

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