We propose a multiple-slot silica high-mesa waveguide for infrared sensing considering the possibility of realizing a higher portion of an optical field out of the waveguide (which is defined as "Γ air "). Low Γ air leads to less light power being used for sensing, which limits sensing capabilities. The simulated results showed a high Γ air of 20.3% for a quadruple structure under λ = 1550 nm. A scattering loss of 0.06 dB/cm was predicted theoretically as well.