Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19

Breiman, Adrien; Ruvoën-Clouet, Nathalie; Deleers, Marie; Beauvais, Tiffany; Jouand, Nicolas; Rocher, Jézabel; Bovin, Nicolai V.; Labarrière, Nathalie; Kenz, Hanane El; Pendu, Jacques Le

doi:10.3389/fmicb.2021.641460

Cited by 12 publications

(19 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C1GALT1C1 is a molecular chaperone required for the expression of active T-synthase, the only enzyme that glycosylates the Tn antigen [ 96 ]. Anti-Tn antibodies are lower in COVID-19 patients than noninfected individuals and individuals with blood group A [ 97 ]. Anti-Tn antibodies may protect against COVID-19 [ 97 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19

et al. 2022

View full text Add to dashboard Cite

In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need for respiratory support or death due to COVID-19, respectively. After multiple testing correction, using genetic instruments and under the assumptions of Mendelian Randomization, our results were consistent with higher blood levels of five proteins GCNT4, CD207, RAB14, C1GALT1C1, and ABO being causally associated with an increased risk of hospitalization or respiratory support/death due to COVID-19 (ORs = 1.12–1.35). Higher levels of FAAH2 were solely associated with an increased risk of hospitalization (OR = 1.19). On the contrary, higher levels of SELL, SELE, and PECAM-1 decrease risk of hospitalization or need for respiratory support/death (ORs = 0.80–0.91). Higher levels of LCTL, SFTPD, KEL, and ATP2A3 were solely associated with a decreased risk of hospitalization (ORs = 0.86–0.93), whilst higher levels of ICAM-1 were solely associated with a decreased risk of respiratory support/death of COVID-19 (OR = 0.84). Our findings implicate blood group markers and binding proteins in both hospitalization and need for respiratory support/death. They, additionally, suggest that higher levels of endocannabinoid enzymes may increase the risk of hospitalization. Our research replicates findings of blood markers previously associated with COVID-19 and prioritises additional blood markers for risk prediction of severe forms of COVID-19. Furthermore, we pinpoint druggable targets potentially implicated in disease pathology.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Anti-Tn antibodies are lower in COVID-19 patients than noninfected individuals and individuals with blood group A [ 97 ]. Anti-Tn antibodies may protect against COVID-19 [ 97 ]. The glycosylation of Tn by C1GALT1C1 may suppress these antibodies.…”

Section: Discussionmentioning

confidence: 99%

Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 411 – 413 Compared to non-infected individuals, the anti-Tn antibodies level in COVID-19 patients are significantly lower, suggesting that natural anti-Tn antibodies may be protective against COVID-19. 414 In addition, the HIV-1 Env Fab-dimerized glycan (FDG)-reactive antibodies are an anti-glycan antibody that recognize high mannose glycans of SARS-CoV-2, indicating the potential prospects of these natural antibodies in SARS-CoV-2 treatment. 415 …”

Section: Introductionmentioning

confidence: 99%

The glycosylation in SARS-CoV-2 and its receptor ACE2

Gong

Qin

Dai

et al. 2021

Sig Transduct Target Ther

140

170

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 235 million individuals and led to more than 4.8 million deaths worldwide as of October 5 2021. Cryo-electron microscopy and topology show that the SARS-CoV-2 genome encodes lots of highly glycosylated proteins, such as spike (S), envelope (E), membrane (M), and ORF3a proteins, which are responsible for host recognition, penetration, binding, recycling and pathogenesis. Here we reviewed the detections, substrates, biological functions of the glycosylation in SARS-CoV-2 proteins as well as the human receptor ACE2, and also summarized the approved and undergoing SARS-CoV-2 therapeutics associated with glycosylation. This review may not only broad the understanding of viral glycobiology, but also provide key clues for the development of new preventive and therapeutic methodologies against SARS-CoV-2 and its variants.

show abstract

“…The pattern of specificity of anti‐Tn antibodies depends on the person's belonging to the ABO blood group system 45 …”

Section: Discussionmentioning

confidence: 99%

“…For the other four Abs, there was no difference between incidence in norm and pathology. The pattern of specificity of anti-Tn antibodies depends on the person's belonging to the ABO blood group system 45 2a…”

Section: Discussionmentioning

confidence: 99%

Repertoire of glycan‐binding placenta‐associated antibodies in healthy pregnancy and in pre‐eclampsia

et al. 2022

View full text Add to dashboard Cite

A possible mechanism of the immune tolerance in pregnancy is production of blocking antibodies which reside in placenta and protect foetal allogeneic cells from the mother's immune system. Their epitope specificity, as well as the nature of the biomolecules masked by them, is unknown. For better understanding of this phenomenon, we attempted to characterize the specificity of antibodies isolated from placentas of women with healthy pregnancy and pre‐eclampsia (PE). It was found that: (1) the repertoire of placental antibodies is significantly less variable and qualitatively different from the peripheral blood; (2) with PE, the repertoire of placental antibodies is narrower than in healthy pregnancy; (3) some antibodies are found almost exclusively in the placenta, and some – only in the placenta of healthy women.

show abstract

Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19

Cited by 12 publications

References 75 publications

Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19

Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19

The glycosylation in SARS-CoV-2 and its receptor ACE2

Repertoire of glycan‐binding placenta‐associated antibodies in healthy pregnancy and in pre‐eclampsia

Contact Info

Product

Resources

About