Low Levels of High-Density Lipoprotein Cholesterol Do Not Predict the Incidence of Type 2 Diabetes in an Iranian High-Risk Population: The Isfahan Diabetes Prevention Study

Janghorbani, Mohsen; Amini, Masoud; Aminorroaya, Ashraf

doi:10.1900/rds.2016.13.187

Cited by 3 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, in the Hawaii-Los Angeles-Hiroshima study, Hirano found that HDL is a predictor of T2DM for Japanese-American and native Japanese people independently of age and gender [ 31 ]. In a population-based longitudinal survey conducted on a cohort of high-risk individuals in Iran, Janghorbani et al showed that low HDL levels are a weak predictor of T2DM independently of age and gender [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Patterns of changes in serum lipid profiles in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background Lipid abnormality pervasively is associated with the risk of type 2 diabetes mellitus. To the best of our knowledge, there is no study that has examined the longitudinal changes in a wide range of serum lipid profiles in prediabetic subjects in association with the risk of developing type 2 diabetes mellitus in the future. This study aimed to identify the patterns of changes in lipid profiles over time in prediabetic patients and to classify these subjects in order to highlight which patients are at high risk for future diabetes. Methods This prospective 16-year (2003–2019) cohort study was conducted among 1228 prediabetic subjects. The study subjects were followed, and the changes in their lipid profiles, including triglycerides, cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, were evaluated. The latent Markov model was used for data analysis. Results The mean (standard deviation) age of subjects was 44.0 (6.8) years, and 73.6% of them were female. The latent Markov model identified two latent states of subjects in terms of changes in lipid profiles: a low tendency to progress diabetes / high tendency to progress diabetes (74, 26%). The latent Markov model showed that the transition probability from a “low tendency to progress diabetic” state to a “high tendency to progress diabetic” state was lower than the transition probability from “high tendency to progress diabetic” state to “low tendency to progress diabetic” state. Conclusions The present study showed that more than half of the first-degree relatives of T2DM had approximately normal lipid profiles and that these patients are more inclined to transition from a higher- to a lower-tendency diabetic state. These findings confirm the value of regular screening of first-degree relatives of T2DM. Moreover, preventive intervention strategies are recommended to reduce their risk of developing T2DM.

show abstract

Section: Discussionmentioning

confidence: 99%

Patterns of changes in serum lipid profiles in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The lower level of HDL-C, is associated with a higher risk of DM 18 . On the other hand, HDL-C has not been a reliable predictor for DM 28 . Therefore, when ALT increases and HDL-C decreases, the ALT/HDL-C ratio increases and can be a more effective predictor for DM compared to other risk factors 20 .…”

Section: Discussionmentioning

confidence: 91%

The association of ALT to HDL-C ratio with type 2 diabetes in 50–74 years old adults: a population-based study

Emamian,

Hashemi

et al. 2024

Sci Rep

View full text Add to dashboard Cite

There is limited information about the relationship between diabetes mellitus (DM) and ALT to HDL-C ratio. This study aims to investigate this relationship for the first time in Iran. The data of this study were taken from the third phase of the Shahroud Eye Cohort Study, which was conducted in 2019 with the participation of 4394 people aged 50–74. ALT and HDL-C levels were measured using a BT-1500 autoanalyzer. The mean ALT/HDL-C ratio was reported along with 95% confidence intervals (CI). The multiple logistic regression was used to examine the association between this ratio and DM, while controlling for the effects of other independent variables. The mean and standard deviation of the ALT/HDL-C ratio in all participants were 16.62 ± 11.22 (95% CI 16.28–16.96). The prevalence of DM was 34.7% and individuals with DM had a mean ALT/HDL-C ratio that was 1.80 units higher than those without diabetes (P < 0.001). Also, in individuals with DM, the HDL-C was found to be 0.035 (mmol/L) lower (P < 0.001), while ALT was 1.13 (IU/L) higher (P < 0.001) compared to those without diabetes. Additionally, after controlling for confounding factors, the odds of developing DM increased in a non-linear manner with an increase in the ALT/HDL-C ratio. Abdominal obesity, advanced age, female gender, and hypertension were also found to be associated with increased odds of DM. In conclusion, an increase in the ALT/ HDL-C ratiowas associated with higher odds of DM. This ratio can serve as an important predictor for diabetes mellitus.

show abstract

“…In contrast, Hirano in the Hawaii-Los Angeles-Hiroshima study found that HDL is a predictor of T2DM, independent of age and gender in both Japanese-American and native Japanese(37). Janghorbani et al in a population based longitudinal survey showed that low HDL level was a weak predictor of T2DM independent of age and gender in a cohort of high-risk individuals in Iran (38).…”

Section: Discussionmentioning

confidence: 97%

Patterns of changes in serum lipid profile in prediabetic patients: Results from a 16-year prospective cohort study

Safari

Amini

Aminorroaya

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background Lipids abnormality pervasively is associated with the risk of Type 2 diabetes mellitus. To the best of our knowledge, there is no study that examined the longitudinal changes in wide range of serum lipid profile in prediabetic subjects in association with the risk of Type 2 diabetes mellitus in future. This study aimed to identify the patterns of changes in lipids profile over time in prediabetic patients and classify these subjects in order to highlight the high risk people for future diabetes risk. Methods This prospective 16-year (2003–2019) cohort study was conducted among 1228 prediabetic subjects. The study subjects followed over time and changes in their lipid profile include Triglycerides, Cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol was evaluated. Latent Markov model was used for data analysis. Results Mean (standard deviation) age of subjects was 44.00 (6.86) years and 73.6% were female. Latent Markov model identified two latent states of subjects in terms of change in lipid profile: low tendency to progress diabetes/ high tendency to progress diabetes (74%/ 26%). Latent Markov model showed that the transition probability from “low tendency to progress diabetic” state to “high tendency to progress diabetic” state was lower than the transition probability from “high tendency to progress diabetic” state to “low tendency to progress diabetic” state. Conclusion In conclusion, abnormality of serum lipid profile remains a significant and growing problem in prediabetic subjects as high risk population. The reduction in the problem burden will require changes at the policy level as well as at the personal level.

show abstract

Low Levels of High-Density Lipoprotein Cholesterol Do Not Predict the Incidence of Type 2 Diabetes in an Iranian High-Risk Population: The Isfahan Diabetes Prevention Study

Cited by 3 publications

References 42 publications

Patterns of changes in serum lipid profiles in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients

Patterns of changes in serum lipid profiles in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients

The association of ALT to HDL-C ratio with type 2 diabetes in 50–74 years old adults: a population-based study

Patterns of changes in serum lipid profile in prediabetic patients: Results from a 16-year prospective cohort study

Contact Info

Product

Resources

About