Low levels of dietary methylmercury inhibit growth and gonadal development in juvenile walleye (Stizostedion vitreum)

Friedmann, Andrew S.; Watzin, Mary C.; Brinck‐Johnsen, Truls; Leiter, James C.

doi:10.1016/0166-445x(96)00796-5

Cited by 122 publications

(81 citation statements)

References 35 publications

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“…All such functional disturbances might have been caused by excessive release of reactive oxygen species (ROS) driven by Hg accumulation (Bansal et al, 1992;Lund et al, 1993). Consistent with the findings in this study, impaired growth and poor gonad development caused by dietary MeHg have been reported in juvenile walleye (Friedmann et al, 1996), Sacramento blackfish (Houck and Cech Jr, 2004) and Green & White sturgeon .…”

Section: Discussionsupporting

confidence: 80%

Synergistic Effects of Dietary Vitamins C and E on Methylmercury-Induced Toxicity in Juvenile Olive Flounder Paralichthys olivaceus

Park¹,

Yun²,

Lee³

et al. 2015

Fisheries and aquatic sciences

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This experiment was conducted to evaluate the synergistic effects of vitamin C and E on methylmercury (MeHg) toxicity in juvenile olive flounder Paralichthys olivaceus. In a 3×3 factorial design, 9 experimental diets containing three different vitamin C (0, 200 or 400 mg/kg diet in the form of l-ascorbyl-2-monophosphate) and vitamin E (0, 100 or 200 mg/kg diet in the form of dl-α-tocopheryl acetate) levels with the Hg toxicity level (20 mg/kg diet in the form of MeHg) were formulated. Triplicate groups of fish averaging 2.3 ± 0.05 g (mean ± SD) were fed one of the 9 diets in a flow through system for 8 weeks. Fish fed 400 mg vitamin C/ kg diet with 100 or 200 mg vitamin E/kg diet showed significantly (P < 0.05) higher weight gain (WG) than did fish fed the other diets. Fish fed 400 mg vitamin C/kg diet at all vitamin E levels and those which fed vitamin C and E equally at a rate of 200 mg/kg diet showed significantly (P < 0.05) higher feed efficiency (FE), specific growth rate (SGR) and protein efficiency ratio (PER) than did fish fed the other diets. Fish fed 200 and 400 mg vitamin C/kg diet exhibited significantly (P < 0.05) lower Hg concentration in their muscle as well as kidney than did fish fed the other diets. Therefore, these results clearly indicated that the synergistic effects of these two vitamins on MeHg toxicity by supplementing dietary vitamin C (200 and 400 mg/kg diet) with vitamin E (100 and 200 mg/kg diet) in juvenile olive flounder.

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Section: Discussionsupporting

confidence: 80%

Synergistic Effects of Dietary Vitamins C and E on Methylmercury-Induced Toxicity in Juvenile Olive Flounder Paralichthys olivaceus

Park¹,

Yun²,

Lee³

et al. 2015

Fisheries and aquatic sciences

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“…These body burdens are 87-and 130-fold lower than median NOERs and LOERs reported in the literature [25,26] and more than eight times lower than the tissue threshold effect level modeled by Beckvar et al [27]. These data suggest that body burdens of Hg in juvenile P. promelas are not high enough to be of toxicological significance.…”

Section: Mercurymentioning

confidence: 48%

Impact assessment of dredging to remove coal fly ash at the Tennessee Valley Authority Kingston Fossil plant using fathead minnow elutriate exposures

Stanley

Kennedy

Bednar

et al. 2013

Enviro Toxic and Chemistry

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Abstract-On December 22, 2008, failure of an earthen containment structure resulted in the release of approximately 4.1 million m 3 of coal fly ash into the Emory River and the surrounding area from the Tennessee Valley Authority Kingston Fossil Plant near Kingston, Tennessee, USA. The purpose of the present study was to assess the potential of dredging activities performed to remove the fly ash from the river to result in increased risk to pelagic fish, with special consideration of mobilization of metals. Elutriates were created using two sources of fly ash by bubbling with air over 10 d. This elutriate preparation method was designed to represent worst-case conditions for oxidation, metal release, and dissolution. Larval and juvenile Pimephales promelas underwent 10-d exposures to these elutriates. Larval end points included survival and biomass, and juvenile end points included survival, length, biomass, liver somatic index, and bioaccumulation. No significant toxicity was observed. Bioaccumulation of metals in juveniles was found to be primarily attributable to metals associated with particles in the gut. Results suggest little potential for toxicity to related fish species due to fly ash removal dredging activities given the extreme conditions represented by the elutriates in the present study. Environ. Toxicol. Chem.

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“…Fathead minnows (FHM), Pimephales promelas, if fed MeHg-contaminated diets, showed a delay in spawning, a decline in spawning activity, and a decline in the quantities of eggs laid along with increasing MeHg (Hammerschmidt et al, 2002). Besides, dietary MeHg also damages gonadal development in walleye Sander vitreus (Friedmann et al, 1996) and walking catfish Clarias batrachus Joy, 1988, 1992) and leads to testicular atrophy in guppies (Wester, 1991). And there is some evidence suggesting that MeHg inhibits sex hormones that cause secondary sex characteristics and stimulate gonadal development and gametogenesis.…”

Section: Mercurymentioning

confidence: 99%

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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The documents on Metallothioneins (MTs) in aquatic creatures, especially focusing on their function as biomarkers in environmental monitoring programmes, are vast and increasing. There are, however, few papers to summary the physiological role of MTs in aquatic organisms especially on development. The multifaceted roles of MTs include involvement in homeostasis, protection against heavy metals and oxidant damages, and metabolic regulation, sequestration and/or redox control. In this paper, we have collected published information on MTs in aquatic organisms-pisces, amphibians, mammals, etc., and analyzed their function in these aquatic animals. MTs have four main functions in aquatic vertebrate. They are respectively bioaccumulation of toxic metals and detoxification, homeostatic regulation of metals, protection against oxidative stress and neuroprotective mechanism. MTs separate in different tissues and they have various distributions in different tissues of aquatic vertebrate, including liver, gills, kidney, testes, and brain. MTs can be induced by a variety of environmental and physiological factors, among which, heavy metals are the main kind of MTs inducers in aquatic vertebrate. Here we pay more attention on the essential metals copper (Cu) and zinc (Zn) and the non-essential metals cadmium (Cd), silver (Ag), lead (Pb), and mercury (Hg).

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Low levels of dietary methylmercury inhibit growth and gonadal development in juvenile walleye (Stizostedion vitreum)

Cited by 122 publications

References 35 publications

Synergistic Effects of Dietary Vitamins C and E on Methylmercury-Induced Toxicity in Juvenile Olive Flounder Paralichthys olivaceus

Synergistic Effects of Dietary Vitamins C and E on Methylmercury-Induced Toxicity in Juvenile Olive Flounder Paralichthys olivaceus

Impact assessment of dredging to remove coal fly ash at the Tennessee Valley Authority Kingston Fossil plant using fathead minnow elutriate exposures

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

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