Low Levels of Corticotropin-Releasing Hormone during Early Pregnancy Are Associated with Precocious Maturation of the Human Fetus

Class, Quetzal A.; Buß, Claudia; Davis, Elysia Poggi; Gierczak, Matt; Pattillo, Carol; Chicz-DeMet, Aleksandra; Sandman, Curt A.

doi:10.1159/000191213

Cited by 42 publications

(37 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To evaluate programming influences on the fetus, we assessed the consequences of gestational stress during the early second trimester on fetal behavior in the early third trimester. We found that low CRH at 15 gestational weeks, but not later, predicted a more mature fetal heart rate pattern at 25 gestational weeks (Class et al, 2008). This is evidence that endocrine stress exerted influence, on the developing nervous system and that these effects may influence directly or indirectly, birth outcome Sandman et al, 2011b).…”

Section: Fetal Behaviorsupporting

confidence: 49%

Psychobiological Stress and Preterm Birth

Sandman¹,

Davis²,

Glynn³

2012

Preterm Birth - Mother and Child

View full text Add to dashboard Cite

Section: Fetal Behaviorsupporting

confidence: 49%

Psychobiological Stress and Preterm Birth

Sandman¹,

Davis²,

Glynn³

2012

Preterm Birth - Mother and Child

View full text Add to dashboard Cite

“…To evaluate programming influences on the fetus, we assessed the consequences of gestational stress during the early second trimester on fetal behavior in the early third trimester. We found that low pCRH at 15 gestational weeks, but not later, predicted a more mature FHR pattern at 25 gestational weeks [43,44]. This is evidence of gestational stress exerting programming influences on the developing nervous system that is independent of postnatal experiences.…”

Section: Gestational Stress Influences Human Fetal Behaviormentioning

confidence: 72%

Exposure to Prenatal Psychobiological Stress Exerts Programming Influences on the Mother and Her Fetus

Sandman

Davis²,

Buß³

et al. 2011

Neuroendocrinology

Self Cite

243

199

View full text Add to dashboard Cite

Background/Aims: Accumulating evidence from a relatively small number of prospective studies indicates that exposure to prenatal stress profoundly influences the developing human fetus with consequences that persist into childhood and very likely forever. Methods: Maternal/fetal dyads are assessed at ∼20, ∼25, ∼31 and ∼36 weeks of gestation. Infant assessments begin 24 h after delivery with the collection of cortisol and behavioral responses to the painful stress of the heel-stick procedure and measures of neonatal neuromuscular maturity. Infant cognitive, neuromotor development, stress and emotional regulation are evaluated at 3, 6 12 and 24 months of age. Maternal psychosocial stress and demographic information is collected in parallel with infant assessments. Child neurodevelopment is assessed with cognitive tests, measures of adjustment and brain imaging between 5 and 8 years of age. Results:Psychobiological markers of stress during pregnancy, especially early in gestation, result in delayed fetal maturation, disrupted emotional regulation and impaired cognitive performance during infancy and decreased brain volume in areas associated with learning and memory in 6- to 8-year-old children. We review findings from our projects that maternal endocrine alterations that accompany pregnancy and influence fetal/infant/child development are associated with decreased affective responses to stress, altered memory function and increased risk for postpartum depression. Conclusions: Our findings indicate that the mother and her fetus both are influenced by exposure to psychosocial and biological stress. The findings that fetal and maternal programming occur in parallel may have important implications for long-term child development and mother/child interactions.

show abstract

“…83 Successful lactation, therefore, requires mature infant suck-swallow patterns; maternal depression may affect this oromotor development. Exposure to elevated CRH during pregnancy has been linked with differences in neurologic maturation 84 and neuromuscular development. 85 At birth, neonates born to depressed mothers exhibit different suckling responses than those born to euthymic mothers.…”

Section: Infant Developmentmentioning

confidence: 99%

Failed Lactation and Perinatal Depression: Common Problems with Shared Neuroendocrine Mechanisms?

Stuebe

Grewen

Pedersen

et al. 2012

Journal of Women's Health

117

106

View full text Add to dashboard Cite

In the early postpartum period, mother and infant navigate a critical neuroendocrine transition from pregnancy to lactation. Two major clinical problems that occur during this transition are failed lactation and perinatal mood disorders. These disorders often overlap in clinical settings. Failed lactation is common. Although all major medical organizations recommend 6 months of exclusive breastfeeding, only 13% of women in the United States achieve this recommendation. Perinatal mood disorders affect 10% of mothers, with substantial morbidity for mother and child. We hypothesize that shared neuroendocrine mechanisms contribute to both failed lactation and perinatal mood disorders. In this hypothesis article, we discuss data from both animal models and clinical studies that suggest neuroendocrine mechanisms that may underlie these two disorders. Research to elucidate the role of these underlying mechanisms may identify treatment strategies both to relieve perinatal depression and to enable women to achieve their infant feeding goals.

show abstract

Low Levels of Corticotropin-Releasing Hormone during Early Pregnancy Are Associated with Precocious Maturation of the Human Fetus

Cited by 42 publications

References 108 publications

Psychobiological Stress and Preterm Birth

Psychobiological Stress and Preterm Birth

Exposure to Prenatal Psychobiological Stress Exerts Programming Influences on the Mother and Her Fetus

Failed Lactation and Perinatal Depression: Common Problems with Shared Neuroendocrine Mechanisms?

Contact Info

Product

Resources

About