Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor

Koucký, Michal; Malíčková, Karin; Cindrová‐Davies, Tereza; Germanová, Anna; Pařı́zek, Antonı́n; Kalousová, Marta; Hájek, Z; Zima, Tomáš

doi:10.1016/j.jri.2014.04.001

Cited by 35 publications

(24 citation statements)

References 39 publications

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“…Moreover, under some circumstances, Treg cells are able to transdifferentiate into Th17 cells and vice versa . Notwithstanding, diminishing the Treg and/or augmenting the Th17 dynamic profiles in humans can: (i) antecede gestational problems, such as preterm birth (PTB), pre‐eclampsia (PE) or recurrent pregnancy loss (RPL) and (ii) ensue the onset of autoimmune diseases, such as multiple sclerosis (MS) and rheumatoid arthritis (RA) …”

Section: Origin and Characteristics Of Th17 And Treg Cellsmentioning

confidence: 99%

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The T helper type 17/regulatory T cell paradigm in pregnancy

2016

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SummaryT helper type 17 (Th17) and regulatory T (Treg) cells are active players in the establishment of tolerance and defence. These attributes of the immune system enmesh to guarantee the right level of protection. The healthy immune system, on the one hand, recognizes and eliminates dangerous non-self pathogens and, on the other hand, protects the healthy self. However, there are circumstances where this fine balance is disrupted. In fact, in situations such as in pregnancy, the foreign fetal antigens challenge the maternal immune system and Treg cells will dominate Th17 cells to guarantee fetal survival. In other situations such as autoimmunity, where the Th17 responses are often overwhelming, the immune system shifts towards an inflammatory profile and attacks the healthy tissue from the self. Interestingly, autoimmune patients have meliorating symptoms during pregnancy. This connects with the antagonist role of Th17 and Treg cells, and their specific profiles during these two immune challenging situations. In this review, we put into perspective the Th17/ Treg ratio during pregnancy and autoimmunity, as well as in pregnant women with autoimmune conditions. We further review existing systems biology approaches that study specific mechanisms of these immune cells using mathematical modelling and we point out possible future directions of investigation. Understanding what maintains or disrupts the balance between these two opponent yet reciprocal cells in healthy physiological settings, sheds light into the development of innovative pharmacological approaches to fight pregnancy loss and autoimmunity.

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Section: Origin and Characteristics Of Th17 And Treg Cellsmentioning

confidence: 99%

“…At the cellular level, Treg cells are involved in murine fetal acceptance and Koucky et al . report that, in humans, low levels of circulating Treg cells, together with short cervical length, correlate with PTB.…”

Section: Preterm Birthmentioning

confidence: 99%

The T helper type 17/regulatory T cell paradigm in pregnancy

2016

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“…Related preceding research investigated PTL' risk prediction using cervical length and Treg cells [29] and not progesterone's immune effects.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, there are four articles reporting studies of Treg cells in pregnant women with PTL [1,8,9,29], although none of them studied the influence of progesterone treatment on the Treg cell population. Moreover, aims, inclusion criteria, T-cell population studied and conclusions are different among the four studies.…”

Section: Discussionmentioning

confidence: 99%

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Does progesterone administration in preterm labor influence Treg cells?

Areia

Vale-Pereira

Vaz-Ambrósio

et al. 2016

Journal of Perinatal Medicine

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Objectives: The aim of this study was to determine if the actions of progesterone on preterm labor are accomplished through modulation of the percentage of regulatory T-cells (Treg). Methods: The study was a cohort pilot study made in a single center tertiary obstetrical unit with women in preterm labor arrested with tocolytic treatment. Variation of the number and percentage of Treg cells obtained from peripheral blood samples of women with preterm labor were calculated by flow cytometry, before and after progesterone administration. Results: In the paired samples for each patient, there was a significant difference in the Treg cell pool after progesterone treatment, with an increase in both their percentage (48.9 vs. 53; P = 0.07) and absolute number (14.8 vs. 56.5 cells/μL; P = 0.046). Conclusions: This research demonstrated a considerable increase in the Treg cell pool after progesterone treatment. This indicates a possible mechanism for progesterone treatment benefits in preterm labor, potentially increasing its more rational use.

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Dominant immune cells in pregnancy and pregnancy complications: T helper cells (TH1/TH2, TH17/Treg cells), NK cells, MDSCs, and the immune checkpoints

Esparvarinha

Madadi

Aslanian‐Kalkhoran

et al. 2022

Cell Biology International

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Pregnancy problems including recurrent pregnancy loss, repeated implantation failure and pre-eclampsia are common problems in the reproductive ages. Different reasons such as genetic, immunological, and environmental agents and also infections could develop these complications. In those cases in which the cause of the abortion is diagnosed, the chance of a successful pregnancy is increased by eliminating defective factors. However, in patients with unknown causes, there may be an imbalance in immune cells pattern. As a matter of fact, an inappropriate immune response is often associated with a failed pregnancy. Hence, the focus of treatment is to increase tolerance, not to suppress maternal immune system. These findings are linked to an elevated number of Treg cells and immune checkpoints through normal pregnancy. The present review discusses the balance of myeloidderived suppressor cells, natural killer cells, T cells, and immune checkpoints, and also targeting them to maintain pregnancy and prevent associated complications.

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Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor

Cited by 35 publications

References 39 publications

The T helper type 17/regulatory T cell paradigm in pregnancy

The T helper type 17/regulatory T cell paradigm in pregnancy

Does progesterone administration in preterm labor influence Treg cells?

Dominant immune cells in pregnancy and pregnancy complications: T helper cells (TH1/TH2, TH17/Treg cells), NK cells, MDSCs, and the immune checkpoints

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