Low levels of circulating platelet factor 4 (PF4, CXCL4) in subclinically hypothyroid autoimmune thyroiditis

Abstract

The present study demonstrated for the first time that circulating PF4 levels are decreased in subclinically hypothyroid AIT. This result draws attention to the circulating PF4 levels in subclinically hypothyroid AIT and may shed light on further researches at this topic.

Thyroid State Regulates Gene Expression in Human Whole Blood

“…When platelets are activated, PF4 is released from the alpha granules facilitating thrombosis (31). The observation that circulating PF4 levels are decreased in patients with subclinical autoimmune hypothyroidism supports our findings (32). F13A1, another upregulated gene by TH, encodes the coagulation factor XIIIA subunit.…”

RPS27 selectively regulates the expression and alternative splicing of inflammatory and immune response genes in thyroid cancer cells

“…Circulating PF4 levels are decreased in subclinically hypothyroid autoimmune thyroiditis (AIT). 34 Additionally, PF4 can regulate the inflammation within the tumor microenvironment, tumor angiogenesis, and, in turn, tumor growth. 35 The upregulated and downregulated DEGs were enriched in 166 and 211 pathways, respectively.…”

The whole blood DNA methylation patterns of extrinsic apoptotic signalling pathway-related genes in autoimmune thyroiditis among areas with different iodine levels

“…A study has confirmed that PF4 plays a role through caspase-mediated exogenous apoptosis pathway (12) . It was found that the levels of circulating PF4 in subclinical hypothyroidism AIT patients were lower than that in AIT patients with normal thyroid function (13) . In our study, PF4 was selected as a candidate gene to compare the differences in DNA methylation levels between the AIT group and the healthy controls group.…”

“…Platelet factor 4 (PF4) is involved in the extrinsic apoptosis pathway mediated by caspase (12) . The level of circulating PF4 was proved to decrease in subclinically hypothyroid AIT patients (13) . The abnormal expression of these molecules in the serum of AIT patients suggests that extrinsic apoptotic pathway-related molecules may be involved in the pathogenesis of AIT and play an important role.…”