Background:The diminishing investment into the development of new antimicrobials is of significant global concern. This, coupled with the emergence of anti-infective drug resistance, highlights the need to both prolong and optimise the use of existing antimicrobials. Strategies or programs to optimise antimicrobial use fall under the broad heading of antimicrobial stewardship. Aim: To identify the types of antimicrobial stewardship programs in existence in Australian hospitals and their perceived success. Method: Directors of Pharmacy or their nominees (n = 281) working in Australian hospitals were surveyed to identify their institutional antimicrobial stewardship programs. Infectious disease clinicians, infection control nurses and hospital pharmacists were recruited for the qualitative interviews. They were interviewed until saturation of themes was identified. All of the interviews were transcribed verbatim and analysed for common themes.