Low level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor α‐mediated smooth airway muscle dysfunction

Aimbire, Flávio; Bjordal, Jan Magnus; Iversen, Vegard Vereide; Albertini, Regiane; Frigo, Lúcio; Pacheco, Marcos Tadeu Tavares; Castro‐Faria‐Neto, Hugo C.; Chavantes, Maria Cristina; Labat, R; Lopes-Martins, Rodrigo Álvaro Brandão

doi:10.1002/lsm.20357

Cited by 43 publications

(27 citation statements)

References 48 publications

(50 reference statements)

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“…Pro-inflammatory mediators, including TNF-α, IL-1, IL-6, and prostaglandins are all overproduced in chondrocytes in pathological conditions and contribute to amplifying the intraarticular inflammatory process 20,21) . Among these cytokines, IL-6 was detected in patients with OA as well as in patients with rheumatoid arthritis 22) .…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammation Effects of Low Intensity Laser Therapy on Monosodium Iodoacetate-induced Osteoarthritis in Rats

Kim

2013

J Phys Ther Sci

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Abstract.[Purpose] The purpose of this study was to investigate the effects of low intensity laser therapy (LILT) on inflammatory osteoarthritis in the knee joint of rats.[Subjects] Thirty Sprague-Dawley rats were randomly divided into 3 groups with 10 rats each: the normal, control, and LILT groups. The arthritis group was treated with LILT using a gallium-aluminum-arsenide diode laser over during 3 weeks. All treatments were applied once a day, 5 days per week for 21 days. The inflammation cytokine and the articular index were used to assess the arthritic symptoms. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the serum were used as outcome measures.[Results] The arthritis index points of rats in the LILT group were lower than that of the control group. Similarly, TNF-α, IL-1β, and IL-6 concentrations in serum were significantly decreased in the LILT group compared to the control group, which coincided with behavioral studies.[Conclusion] This study shows that LILT is capable of reducing inflammatory cytokine concentrations induced by monosodium iodoacetate osteoarthritis in rats.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammation Effects of Low Intensity Laser Therapy on Monosodium Iodoacetate-induced Osteoarthritis in Rats

Kim

2013

J Phys Ther Sci

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“…The anti-inflammatory effect of LLLT on the TNF-α level in bronchoalveolar lavage fluid after inflammation induced by immune-complex reaction was observed in rats [19]. Moreover, LLLT restores the relaxation response of trachea smooth muscle segments after incubation with TNF-α [20]. However, the action mechanism of LLLT on pulmonary diseases, such as asthma or endotoxemia, is still poorly elucidated.…”

Section: Introductionmentioning

confidence: 95%

Low Level Laser Therapy (LLLT) Decreases Pulmonary Microvascular Leakage, Neutrophil Influx and IL-1β Levels in Airway and Lung from Rat Subjected to LPS-Induced Inflammation

et al. 2008

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“…The mechanisms involved in the analgesic effect of LLLT may also be related to muscle relaxation [38] and the stimulated release of endogenous opioids [39]. Phototherapy is able to reduce inflammation [40] and pain intensity [41] as it stimulates the absorption of inflammatory exudates, which favors the absorption of substances like bradykinin, histamine, and acetylcholine [42].…”

Section: Discussionmentioning

confidence: 98%

Effects of low-level laser therapy (LLLT 808 nm) on lower limb spastic muscle activity in chronic stroke patients

et al. 2016

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A cerebrovascular accident (CVA) may affect basic motor functions, including spasticity that may be present in the upper extremity and/or the lower extremity, post-stroke. Spasticity causes pain, muscle force reduction, and decreases the time to onset of muscle fatigue. Several therapeutic resources have been employed to treat CVA to promote functional recovery. The clinical use of low-level laser therapy (LLLT) for rehabilitation of muscular disorders has provided better muscle responses. Thus, the aim of this study was to evaluate the effect of the application of LLLT in spastic muscles in patients with spasticity post-CVA. A double-blind clinical trial was conducted with 15 volunteer stroke patients who presented with post-stroke spasticity. Both males and females were treated; the average age was 51.5 ± 11.8 years old; the participants entered the study ranging from 11 to 48 months post-stroke onset. The patients participated in three consecutive phases (control, placebo, and real LLLT), in which all tests of isometric endurance of their hemiparetic lower limb were performed. LLLT (diode laser, 100 mW 808 nm, beam spot area 0.0314 cm(2), 127.39 J/cm(2)/point, 40 s) was applied before isometric endurance. After the real LLLT intervention, we observed significant reduction in the visual analogue scale for pain intensity (p = 0.0038), increased time to onset of muscle fatigue (p = 0.0063), and increased torque peak (p = 0.0076), but no significant change in the root mean square (RMS) value (electric signal in the motor unit during contraction, as obtained with surface electromyography). Our results suggest that the application of LLLT may contribute to increased recruitment of muscle fibers and, hence, to increase the onset time of the spastic muscle fatigue, reducing pain intensity in stroke patients with spasticity, as has been observed in healthy subjects and athletes.

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Low level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor α‐mediated smooth airway muscle dysfunction

Abstract: Low level laser therapy partially restores the normal relaxation response in inflamed TSM and normalizes accumulation of cAMP in the presence of isoproterenol.

Cited by 43 publications

References 48 publications

Anti-Inflammation Effects of Low Intensity Laser Therapy on Monosodium Iodoacetate-induced Osteoarthritis in Rats

Anti-Inflammation Effects of Low Intensity Laser Therapy on Monosodium Iodoacetate-induced Osteoarthritis in Rats

Low Level Laser Therapy (LLLT) Decreases Pulmonary Microvascular Leakage, Neutrophil Influx and IL-1β Levels in Airway and Lung from Rat Subjected to LPS-Induced Inflammation

Effects of low-level laser therapy (LLLT 808 nm) on lower limb spastic muscle activity in chronic stroke patients

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