Low-level laser therapy for the treatment of androgenic alopecia: a review

Darwin, Evan; Heyes, Alexandra; Hirt, Penelope A.; Wikramanayake, Tongyu C.; Jiménez, Joaquín J.

doi:10.1007/s10103-017-2385-5

Cited by 58 publications

(50 citation statements)

References 38 publications

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“…10 Other therapeutic options also include low-level laser therapy and platelet-rich plasma therapy. 11,12 The effectiveness of these treatments is limited to partial hair regrowth and the need for more effective treatments remains essential. 5,13 Resurfacing the inflammatory aspects of MPHL and FPHL will allow for a comprehensive understanding of MPHL and FPHL, as well as pave the way for efficacious and novel therapeutic options.…”

Section: Introductionmentioning

confidence: 99%

<p>The Inflammatory Aspect of Male and Female Pattern Hair Loss</p>

Peyravian¹,

Deo²,

Daunert³

et al. 2020

JIR

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Male and female pattern hair loss (MPHL and FPHL, respectively), is the most common cause of hair loss affecting nearly 80 million people in the US, yet treatment options remain limited and lacking. As the need for more effective therapeutics remains unmet, this perspective offers a unique angle by directing attention to the inflammatory aspect of MPHL and FPHL. Evidence and implications of inflammation as a characteristic feature of MPHL and FPHL are highlighted through evaluation of clinical and quantitative data. Comparable results suggest the presence of significant perifollicular inflammatory infiltrates, such as lymphocytes and histiocytes, as well as the involvement of inflammatory genes, such as CASP7 and TNF , in the presentation of MPHL and FPHL. Resurfacing of the inflammatory aspect in MPHL and FPHL pathogenesis will advance future developments in MPHL and FPHL therapeutic options.

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Section: Introductionmentioning

confidence: 99%

<p>The Inflammatory Aspect of Male and Female Pattern Hair Loss</p>

Peyravian¹,

Deo²,

Daunert³

et al. 2020

JIR

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“…In previous studies, the wavelength of 655 nm was proven to be most efficient for hair growth. [ 12 – 15 ] Our helmet-type LLLT device contained a combination of 655-nm LDs and LEDs, and each used a continuous wave form with a maximum power of 5 mW, corresponding to about 2.36 mW/cm 2 . In order to maximize the accessibility of the treatment, we used a protocol in which the clinical device was used for 25 minutes every other day.…”

Section: Discussionmentioning

confidence: 99%

Low-level light therapy using a helmet-type device for the treatment of androgenetic alopecia

Yoon

Lee

et al. 2020

Medicine

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Introduction Androgenetic alopecia is the most common form of hair loss in both sexes. In recent studies, low-level light therapy (LLLT) has been established as an effective treatment for alopecia. The purpose of this study was to evaluate the safety and efficacy of LLLT using a new helmet-type device for the treatment of androgenetic alopecia. Method A randomized, sham device-controlled, double-blind clinical trial was conducted at 2 institutions. Sixty participants diagnosed with androgenetic alopecia aged from 19 to 65 years were recruited. LLLT was performed through a helmet-type device that emitted light with a mean output power of 2.36 mW/cm 2 at a wavelength of 655 nm. Participants were divided into 2 groups, which respectively used the experimental device and a sham device. After tattooing at the central point of the vertex, phototrichograms at that point were obtained at 0, 8, and 16 weeks. The primary endpoint of the study was the difference in the rate of change of hair density between the test group and the control group. Results Comparing the results at baseline and week 16, the experimental group showed an increase in hair density of 41.90 hairs/cm 2 and an increase in hair thickness of 7.50 μm, whereas the control group showed an increase of 0.72 hairs/cm 2 and a decrease of 15.03 μm, respectively ( P < .001). No adverse events or side effects occurred. Conclusion LLLT showed a significant effect on increasing hair density in patients with androgenetic alopecia. LLLT could be a safe and effective treatment for androgenetic alopecia in both sexes.

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“…Interest in the application of lasers to stimulate hair growth was originally generated by anecdotal evidence of paradoxical hypertrichosis during laser epilation . Low‐level laser therapy (LLLT) now appears to be a promising non‐invasive treatment for AGA that is safe for self‐administration, with a pooled increase in hair count comparable with finasteride or minoxidil use .…”

Section: Key Issues In Hair Loss: From Physiology To Treatmentmentioning

confidence: 99%

Dermatology today and tomorrow: from symptom control to targeted therapy

Blume-Peytavi

Bagot

Tennstedt

et al. 2018

Acad Dermatol Venereol

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For many decades and until recently, medical approach to dermatologic diseases has been based on the physician's ability to recognize and treat symptoms. Nowadays, advances in the understanding of the biology of diseases and in technologies for intervening against them have allowed physicians to diagnose and treat underlying disease processes rather than simply addressing the symptoms. This means that rather than addressing ‘the disease in humans’, physicians can now address the particular pathologic (biologic, molecular) disturbance as it presents in the individual patient, i.e., physicians now can practice something much closer to ‘personalized medicine’, leading to greater benefits for the patients and the health of society in general. The deeper understanding of ultraviolet radiation, the importance of photoprotection and increased knowledge about signalling pathways of melanoma and carcinoma have led to more complete care for the dermatologic patient. The current popularity for excessive exposure to the sun, without adequate application of the appropriate photoprotection remedies, is the origin of melanoma, but also for the weakening of the structure and functions of the skin. Indeed, fragility of the skin can affect humans around the world. In the senior population, this skin fragility is accompanied by pruritus, whereas atopic dermatitis is an inflammatory disease with highest prevalence in children and adolescents. Acne, the number one reason for dermatologic consultations worldwide, increases its prevalence in adolescents and in females. Senescent alopecia affects humans after menopause and andropause. The articles in this publication present an overview of the current advanced understanding of the diagnosis and therapeutic approaches in 6 fields of dermatology – dermatopaediatry and gerontodermatology, oncodermatology, hair loss, atopic dermatitis, photoprotection and acne – and thereby serve as a useful compendium of updated information and references for all healthcare professionals who see patients with presentations of the symptoms of these diseases.

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Low-level laser therapy for the treatment of androgenic alopecia: a review

Cited by 58 publications

References 38 publications

<p>The Inflammatory Aspect of Male and Female Pattern Hair Loss</p>

<p>The Inflammatory Aspect of Male and Female Pattern Hair Loss</p>

Low-level light therapy using a helmet-type device for the treatment of androgenetic alopecia

Dermatology today and tomorrow: from symptom control to targeted therapy

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