Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial

Gautam, Ajay Prashad; Fernandes, Donald J; Vidyasagar, M S; Maiya, Arun G.; Guddattu, Vasudeva

doi:10.1016/j.jphotobiol.2015.01.011

Cited by 56 publications

(49 citation statements)

References 24 publications

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“…Previous works showed that LLLT can prevent or mitigate the deleterious effects of the ionizing radiation , however, it is unclear whether LLLT could mitigate the damage only in healthy cells or if the laser radiation would also promote tumor cell recovery after IR. Our results showed different behavior of fibroblasts and tumor cells treated with IR followed by LLLT.…”

Section: Discussionmentioning

confidence: 99%

“…Pre‐clinical and clinical trials report that LLLT following IR is able to reduce cell apoptosis and stimulate revascularization of parotid glands and to improve thyroid and liver functions besides enhancing antioxidant levels and the number of platelets . Clinically, LLLT has showed to reduce the severity of oral mucositis and oral pain in head and neck cancer patients who received radiotherapy .…”

Section: Introductionmentioning

confidence: 99%

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Exploring the effects of low‐level laser therapy on fibroblasts and tumor cells following gamma radiation exposure

Silva¹,

Cabral²,

Camargo³

et al. 2016

Journal of Biophotonics

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Ionizing radiation (IR) induces DNA damage and low-level laser therapy (LLLT) has been investigated to prevent or repair detrimental outcomes resulting from IR exposure. Few in vitro studies, however, explore the biological mechanisms underlying those LLLT benefits. Thus, in this work, fibroblasts and tumor cells are submitted to IR with doses of 2.5 Gy and 10 Gy. After twenty-four-h, the cells are exposed to LLLT with fluences of 30 J cm , 90 J cm , and 150 J cm . Cellular viability, cell cycle phases, cell proliferation index and senescence are evaluated on days 1 and 4 after LLLT irradiation. For fibroblasts, LLLT promotes - in a fluence-dependent manner - increments in cell viability and proliferation, while a reduction in the senescence was observed. Regarding tumor cells, no influences of LLLT on cell viability are noticed. Whereas LLLT enhances cell populations in S and G /M cell cycle phases for both cellular lines, a decrease in proliferation and increase in senescence was verified only for tumor cells. Putting together, the results suggest that fibroblasts and tumor cells present different responses to LLLT following exposure to gamma-radiation, and these promising results should stimulate further investigations. Senescence of tumor cells and fibroblasts on the 4 day after ionizing radiation (IR) and low-level laser therapy (LLLT) exposures. The number of senescent cells increased significantly for tumor cells (a) while for fibroblasts no increment was observed (b). The blue collor indicates senescence activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the effects of low‐level laser therapy on fibroblasts and tumor cells following gamma radiation exposure

Silva¹,

Cabral²,

Camargo³

et al. 2016

Journal of Biophotonics

View full text Add to dashboard Cite

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“…No serious side effects were reported [51]. In a randomized placebo controlled trial conducted by Gantam et al on a group of 46 elderly patients with radiation induced oral mucositis, PBM decreased the severity of oral mucositis and also reduced usage of analgesics [52]. Another randomized placebo controlled trial, which was conducted by Oton-Leite et al on a group of 30 patients with head and neck cancer, resulted in the conclusion that PBM was effective in reducing the severity of chemoradiotherapy-induced oral mucositis [53].…”

Section: Management Of Oral Mucositismentioning

confidence: 98%

“…A summary of randomized double-blind studiesincluding cryotherapy, photobiomodulation (PBM), and usage of palifermin or caphosol is presented in Table 5. [44] 145 patients Prospective randomized study Cryotherapy Kamsvåg T et al (2020) [45] 49 patients Randomized study Cryotherapy Gantam et al (2015) [52] 46 patients Randomized study PBM Oton-Leite et al (2015) [53] 30 patients Randomized study PBM Antunes et al (2013) [54] 94 patients Randomized study PBM Henke et al (2011) [61] 186 patients Randomized study Palifermin Le et al (2011) [62] 94 patients Randomized study Palifermin Raphael et al (2014) [66] 29 patients Randomized study Caphosol…”

Section: Management Of Oral Mucositismentioning

confidence: 99%

Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem—Literature Review

Kusiak

Jereczek‐Fossa

Cichońska

et al. 2020

IJERPH

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Oral mucositis is a toxic side effect of non-surgical cancer treatments: chemotherapy and radiotherapy, which strongly impair quality of life and can not only cause strong pain, but also lead to problems with basic physiological needs as eating and swallowing. Development of oral mucositis is associated with type, dosage, and schedule of radiation or chemotherapy and other factors related to patients. Management of oral mucositis is a valid problem, requiring topical application of anesthetics, coating agents, cryotherapy, low level laser therapy, pharmacological methods as usage of keratinocyte growth factors, supplementation of vitamins, and a proper diet. Another approach to oral mucositis measurement includesphotobiomodulation, which brings analgesic and anti-inflammatory effects.Although oral mucositis is a general health issues, the role of proper dental care is essential. It should include elimination of all potential sources of mucosal injury and microorganisms inhabiting theoral cavity through oral hygiene education, professional management ofdental plaque, and treatment of the caries and periodontium, which are necessary to reduce the risk of inflammation in the oral cavity. This paper describes the possibilities of monitoring oral mucositis, taking into account the latest therapeutic achievements.

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“…OM occurs in over 80% of patients undergoing haematopoietic stem cell therapy (HSCT), in addition to a high incidence in head and neck radiotherapy (HNRT). OM is also associated as a common complication (40%) of the management of many other types of cancer chemotherapy treatment [ 3 , 4 ]. The pathology of OM is associated with pro-inflammatory pathways consequent upon the chemotherapeutically and radiotherapy-induced disruption of basal cells of the oral surface epithelium.…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation and Oral Mucositis: A Systematic Review

et al. 2020

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Oral mucositis (OM) is a debilitating complication of chemotherapy, and head and neck radiotherapy. In an effort to offer the best possible advice within the limitations of published research, a systematic review with an extended discussion and commentary on dosimetry and dose delivery is presented. Using keywords as listed, Pubmed, Google Scholar and Cochrane databases were searched during a period extending from 1995 to 2019. A total of 782 abstracts were identified. A total of 50 papers were analysed, and of these, 29 satisfied criteria required for systematic review in accordance with an optimized PRISMA statement. Clinical outcome as reported was subject to analysis with respect to time of intervention, incidence and severity of oral mucositis, and pain amelioration, and a comprehensive combined univariate and multivariate statistical analysis of the methods employed was performed. Recommendations are made with respect to the timing of the intervention. Moreover, there is an extended discussion available on the treatment care rationale of photobiomodulation (PBM), and its adjunctive association with OM. In conclusion, early prophylactic application offers clear advantages in clinical management. The many studies and associated variables and covariables assessed here revealed a choice of delivery techniques, associated wavelengths and many further indices to consider with regard to the accomplishment of optical parameters. It is therefore our recommendation that clinicians use PBM as a therapy with a full and proper understanding and training in order to optimise the clinical effects achievable.

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Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial

Cited by 56 publications

References 24 publications

Exploring the effects of low‐level laser therapy on fibroblasts and tumor cells following gamma radiation exposure

Exploring the effects of low‐level laser therapy on fibroblasts and tumor cells following gamma radiation exposure

Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem—Literature Review

Photobiomodulation and Oral Mucositis: A Systematic Review

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