Low level laser therapy (830nm) improves bone repair in osteoporotic rats: Similar outcomes at two different dosages

Bossini, Paulo Sérgio; Rennó, Ana Cláudia Muniz; Ribeiro, Daniel Araki; Fangel, Renan; Ribeiro, Alison; Lahoz, Manoela de Assis; Parizotto, Nivaldo Antônio

doi:10.1016/j.exger.2011.11.005

Cited by 66 publications

(73 citation statements)

References 25 publications

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“…The osteogenic potential of LLLT has been demonstrated by many studies (13,15). However, the existence of window specificity at certain wavelengths and energy dosages also is well known (12,13,15).…”

Section: Discussionmentioning

confidence: 99%

“…However, the existence of window specificity at certain wavelengths and energy dosages also is well known (12,13,15). It means that a proper energy needs to be offered to the tissue in order to determine physiological modifications and consequently, stimulatory effects to the tissue (18).…”

Section: Discussionmentioning

confidence: 99%

“…Over time, this process leads to an increase in bone density and biomechanical properties in normal and pathological bone conditions, such as osteoporosis and DM (15,23). Moreover, many authors evidenced the osteogenic potential of LLLT (12,13,15). It is well established that, laser light is able of interacting with bone tissue, modulating bone cell biochemical reactions and stimulating mitochondrial respiration.…”

Section: Bone Densitometrymentioning

confidence: 99%

“…Studies have showed that LLLT is able to modulate cell metabolism and stimulate mitochondrial respiration, particularly in the production of molecular oxygen and ATP synthesis (11)(12)(13). These effects produce an increase in DNA, RNA and cell cycle regulatory protein synthesis, which stimulate cell proliferation (11,14).…”

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confidence: 99%

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Low-level laser therapy associated to a resistance training protocol on bone tissue in diabetic rats

Patrocínio-Silva

Souza

Goulart

et al. 2016

Arch. Endocrinol. Metab.

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Objective: The present study aimed to evaluate the in vivo response of a resistance training and low-level laser therapy (LLLT) on tibias and femurs of rats with diabetes mellitus (DM). Materials and methods: Forty male Wistar rats were randomly distributed into four experimental groups: control group (CG), diabetic group (DG), diabetic trained group (TG) and diabetic trained and laser irradiated group (TLG). DM was induced by streptozotocin (STZ) and after two weeks laser and resistance training started, performed for 24 sessions, during eight weeks. At the end of the experiment, animals were euthanized and tibias and femurs were removed for analysis. Histological, histomorphometrical, immunohistochemistry and mechanical analyses were performed. Results: Trained groups, with or without laser irradiation, showed increased cortical area, bone density and biomechanical properties. The immunohistochemical analysis revealed that TG and TLG demonstrated an increased RUNX2 expression. RANK-L immunoexpression was similar for all experimental groups. Conclusion: In conclusion, it can be suggested that the resistance exercise program stimulated bone metabolism, culminating in increased cortical tibial area, bone mineral content, bone mineral density and biomechanical properties. Furthermore, the association of physical exercises and LLLT produced higher values for bone mineral content and stiffness. Consequently, these data highlight the potential of physical exercise in the management of bone loss due to DM and the possible extra osteogenic stimulus offered by lasertherapy. Further long-term studies should be carried out to provide additional information. Arch Endocrinol Metab. 2016;60(5):457-64

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Bone Densitometrymentioning

confidence: 99%

mentioning

confidence: 99%

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Low-level laser therapy associated to a resistance training protocol on bone tissue in diabetic rats

Patrocínio-Silva

Souza

Goulart

et al. 2016

Arch. Endocrinol. Metab.

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“…Values found for the limb withdrawal threshold (in grams) for the pressure performed on the plantar surface (Plantar) and close to the incision (Local) in the pre-injury (Pre) times, 10 (10') and 60 (60') minutes of awakening. Discussion LLLT is a useful tool for the therapeutic field, aiming tissue repair (Bossini et al, 2012;Cury et al, 2013;Hussein, Alfars, Falih, & Hassan, 2011;Vasilenko et al, 2010), anti-inflammatory effects (Chen, Huang, Sharma, & Hamblin, 2011;Marcos et al, 2011) and analgesia (Chow et al, 2007;Chow, Johnson, Lopes-Martins, & Bjordal, 2009;Chow, Armati, Laakso, Bjordal, & Baxter, 2011;Eslamian, Shakouri, Ghojazadeh, Nobari, & Eftekharsadat, 2012;Rayegani et al, 2011;Yan et al, 2011). However, Aras et al (2010), in a review study, indicate a possible dubious effect of low power laser associated with anesthetics, since it can help or hinder the effects of anesthesia.…”

Section: Evaluation Of Nociceptionmentioning

confidence: 99%

<b>Interaction between low level laser therapy and anesthesia in wistar rats

Rocha

Silva

Meireles

et al. 2016

Acta Sci. Health Sci.

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ABSTRACT. The aim was to assess whether the low level laser therapy (LLLT), 660 nm, can lower the effect of injectable anesthetics in rats. Wistar rats (n = 20) were used in two steps: 1) grip strength test and measuring the anesthesia time for control (G1A) and irradiated (G1AL) groups; 2) after 15 days, rats received new anesthesia injection and were evaluated for nociception (G2A -control; G2AL -laser). Anesthesia was induced by ketamine hydrochloride (75 mg kg ), by intraperitoneal injection, according to the body weight. LLLT used was 660 nm at four sites along the right hind limb. Anesthesia time was shorter for the G1AL (p = 0.0031). There were significant differences between pre-and post-intervention in the grip strength test (p < 0.001), but no differences were detected between groups (p = 0.459). For nociception, G2AL achieved higher values than G2A (p = 0.019 and p = 0.032), and also for the comparison between pre-injury values with the following values (p < 0.001) although no significant difference was found between 10 and 60 minutes (p > 0.05). It can be concluded that the LLLT caused no significant reduction on the effect of anesthesia.Keywords: low-level laser therapy. anesthesia. pain measurement.Interações entre laser de baixa potência e anestesia em ratos wistar RESUMO. O objetivo deste estudo é avaliar se o laser de baixa potência (LBP) pode desempenhar algum efeito na diminuição da ação de anestésicos injetáveis. Foram utilizados 20 ratos Wistar, em duas etapas: 1) realizado teste de força de preensão e contagem de tempo de anestesia para animais controle (G1A) e irradiados (G1AL); 2) após 15 dias, novo procedimento anestésico e avaliada a nocicepção (G2A -controle; G2AL -laser). Foram utilizados os anestésicos Quetamina (75 mg kg -1 ) e Xilazina (10 mg kg -1 ), de acordo com o peso corporal, com injeção intraperitoneal. O laser utilizado foi 660 nm, em 4 locais, ao longo do membro pélvico direito. O tempo cronometrado de anestesia foi menor para G1AL (p = 0,0031). Na avaliação da força de preensão, houve diferenças significativas (p < 0,001) entre o momento pré x pós, mas não entre os grupos (p = 0,459). Para a nocicepção, G2AL obteve valores maiores do que G2A (p = 0,019 e p = 0,032), bem como ao comparar os valores pré-lesão com os seguintes (p < 0,001), mas sem diferenças entre 10 e 60 minutos (p > 0,05). Conclui-se que o LBP não apresentou grandes interações com relação à diminuição do efeito da anestesia.Palavras-chave: terapia a laser de baixa intensidade. anestesia. medição da dor.

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Laser Therapy for Exotic Small Mammals

Mayer

Ness²

2017

Laser Therapy in Veterinary Medicine

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Low level laser therapy (830nm) improves bone repair in osteoporotic rats: Similar outcomes at two different dosages

Cited by 66 publications

References 25 publications

Low-level laser therapy associated to a resistance training protocol on bone tissue in diabetic rats

Low-level laser therapy associated to a resistance training protocol on bone tissue in diabetic rats

<b>Interaction between low level laser therapy and anesthesia in wistar rats

Laser Therapy for Exotic Small Mammals

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