Low-level arsenic exposure and developmental neurotoxicity in children: A systematic review and risk assessment

Tsuji, Joyce S.; Garry, Michael R.; Pérez, Vanessa; Chang, Ellen T.

doi:10.1016/j.tox.2015.09.002

Cited by 117 publications

(59 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While there is extensive literature on the health impacts of arsenic exposure in adult populations and a growing literature on impaired neurodevelopment function in children (Tsuji et al 2015), there is relatively little epidemiologic research evaluating the effects of in utero arsenic exposure on pregnancy outcomes and early life. Arsenic readily crosses the placental barrier and thus may influence fetal development.…”

Section: Introductionmentioning

confidence: 99%

Associations between prenatal arsenic exposure with adverse pregnancy outcome and child mortality

Shih

Islam

Hore

et al. 2017

Environmental Research

View full text Add to dashboard Cite

Background Chronic arsenic exposure is a public health concern in many parts of the world, with elevated concentrations in groundwater posing a threat to millions of people. Arsenic is associated with various cancers and an array of chronic diseases; however, the relationship with adverse pregnancy outcomes and child mortality is less established. Objectives We evaluated associations between individual-level prenatal arsenic exposure with adverse pregnancy outcomes and child mortality in a pregnancy study among 498 women nested in a larger population-based cohort in rural Bangladesh. Methods Creatinine-adjusted urinary total arsenic concentration, a comprehensive measure of exposure from water, food, and air sources, reflective of the prenatal period was available for participants. Self-reported pregnancy outcomes (livebirth, stillbirth, spontaneous/elective abortion) were ascertained. Generalized estimating equations, accounting for multiple pregnancies of participants, were used to estimate odds ratios and 95% confidence intervals in relation to adverse pregnancy outcomes. Vital status of livebirths was subsequently ascertained through November 2015. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals in relation to child mortality. Results We observed a significant association between prenatal arsenic exposure and the risk of stillbirth (greater than median; adjusted OR=2.50; 95% CI=1.04, 6.01). We also observed elevated risk of child mortality (greater than median; adjusted HR=1.92; 95% CI=0.78, 4.68) in relation to prenatal arsenic exposure. Conclusions Prospective studies should continue to evaluate prenatal and early life health effects of arsenic exposure and arsenic remediation strategies for women of child-bearing age.

show abstract

Section: Introductionmentioning

confidence: 99%

Associations between prenatal arsenic exposure with adverse pregnancy outcome and child mortality

Shih

Islam

Hore

et al. 2017

Environmental Research

View full text Add to dashboard Cite

show abstract

“…It has been estimated that approximately 19.6 million people are exposed to arsenic via consumption of groundwater in China1. There is increasing epidemiological evidence indicating that exposure to arsenic was associated with skin pathologies, chronic obstructive pulmonary disease, cardiovascular diseases, diabetes, hepatitis, developmental neurotoxicity, adverse birth outcomes, reduced sperm quality and genotoxicity234567. In addition, arsenic was classified as a carcinogen, which has been linked with the onset and progression of tumors in lung, liver, kidney, skin and bladder28.…”

mentioning

confidence: 99%

Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity

Huang

Luo²,

Alamdar

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Arsenic is a widespread metalloid in environment, whose exposure has been associated with a broad spectrum of toxic effects. However, a global view of arsenic-induced male reproductive toxicity is still lack, and the underlying mechanisms remain largely unclear. Our results revealed that arsenic exposure decreased testosterone level and reduced sperm quality in rats. By conducting an integrated proteomics and metabolomics analysis, the present study aims to investigate the global influence of arsenic exposure on the proteome and metabolome in rat testis. The abundance of 70 proteins (36 up-regulated and 34 down-regulated) and 13 metabolites (8 increased and 5 decreased) were found to be significantly altered by arsenic treatment. Among these, 19 proteins and 2 metabolites were specifically related to male reproductive system development and function, including spermatogenesis, sperm function and fertilization, fertility, internal genitalia development, and mating behavior. It is further proposed that arsenic mainly impaired spermatogenesis and fertilization via aberrant modulation of these male reproduction-related proteins and metabolites, which may be mediated by the ERK/AKT/NF-κB-dependent signaling pathway. Overall, these findings will aid our understanding of the mechanisms responsible for arsenic-induced male reproductive toxicity, and from such studies useful biomarkers indicative of arsenic exposure could be discovered.

show abstract

“…Reports of skin lesions and hepatomegaly due to persistent use of drinking water with high concentrations of arsenic in West Bengal appeared in the 1980s [244,245]. In more recent years, several authors have described health effects including skin lesions, respiratory disease, impaired cognition, and cancer due to arsenic exposure in Bangladesh and other countries [241,[246][247][248][249]). …”

Section: Reducing Arsenic Uptakementioning

confidence: 99%

Managing Water and Soils to Achieve Adaptation and Reduce Methane Emissions and Arsenic Contamination in Asian Rice Production

Wichelns

2016

Water

View full text Add to dashboard Cite

Rice production is susceptible to damage from the changes in temperature and rainfall patterns, and in the frequency of major storm events that will accompany climate change. Deltaic areas, in which millions of farmers cultivate from one to three crops of rice per year, are susceptible also to the impacts of a rising sea level, submergence during major storm events, and saline intrusion into groundwater and surface water resources. In this paper, I review the current state of knowledge regarding the potential impacts of climate change on rice production and I describe adaptation measures that involve soil and water management. In many areas, farmers will need to modify crop choices, crop calendars, and soil and water management practices as they adapt to climate change. Adaptation measures at the local, regional, and international levels also will be helpful in moderating the potential impacts of climate change on aggregate rice production and on household food security in many countries. Some of the changes in soil and water management and other production practices that will be implemented in response to climate change also will reduce methane generation and release from rice fields. Some of the measures also will reduce the uptake of arsenic in rice plants, thus addressing an important public health issue in portions of South and Southeast Asia. Where feasible, replacing continuously flooded rice production with some form of aerobic rice production, will contribute to achieving adaptation objectives, while also reducing global warming potential and minimizing the risk of negative health impacts due to consumption of arsenic contaminated rice.

show abstract

Low-level arsenic exposure and developmental neurotoxicity in children: A systematic review and risk assessment

Cited by 117 publications

References 66 publications

Associations between prenatal arsenic exposure with adverse pregnancy outcome and child mortality

Associations between prenatal arsenic exposure with adverse pregnancy outcome and child mortality

Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity

Managing Water and Soils to Achieve Adaptation and Reduce Methane Emissions and Arsenic Contamination in Asian Rice Production

Contact Info

Product

Resources

About