Low Iron Stores in Otherwise Healthy Children Affect Electrocardiographic Markers of Important Cardiac Events

Karadeniz, Cem; Özdemir, Rahmi; Demirol, Mustafa; Katipoğlu, Nagehan; Yozgat, Yılmaz; Meşe, Timur; Ünal, Nurettin

doi:10.1007/s00246-017-1596-7

Cited by 10 publications

(12 citation statements)

References 35 publications

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“…P wave dispersion was not measured if fewer than nine leads were eligible for analysis. 12 The QT interval was measured from the beginning of the QRS complex to the end of the T wave and corrected for heart rate using the Bazett formula (QTc = QT/ p R − R interval). 13 The QT dispersion was calculated for at least 8 of the 12 leads and usually included leads I, II, and V5.…”

Section: Electrocardiography and Echocardiographymentioning

confidence: 99%

“…The differences between the maximum and minimum QT and QTc intervals were defined as the QT and QTc dispersions, respectively. 12 The T peak to end interval was defined as the interval from the peak of T wave to the end of T wave. We defined T peak to end as the intersection point of the tangent to the downward slope of the T wave with the isoelectric line.…”

Section: Electrocardiography and Echocardiographymentioning

confidence: 99%

“…The T peak to end/QT ratio was calculated from these measurements. 12 The same paediatric cardiology specialist who took the electrocardiography measurements performed the echocardiographic examination using a Philips Ultrasound System (model iE33, Philips Medical Systems, Andover) and an S3-1 probe. Conventional echocardiographic measurements were made according to the standards of the American Echocardiography Society.…”

Section: Electrocardiography and Echocardiographymentioning

confidence: 99%

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Evaluation of electrocardiographic markers of cardiac arrhythmic events and their correlation with cardiac iron overload in patients with β-thalassemia major

et al. 2020

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Iron overload is associated with an increased risk of atrial and ventricular arrhythmias. Data regarding the relationship between electrocardiographic parameters of atrial depolarisation and ventricular repolarisation with cardiac T2* MRI are scarce. Therefore, we aimed to investigate these electrocardiographic parameters and their relationship with cardiac T2* value in patients with β-thalassemia major. In this prospective study, 52 patients with β-thalassemia major and 52 age- and gender-matched healthy patients were included. Electrocardiographic measurements of QT, T peak to end interval, and P wave intervals were performed by one cardiologist who was blind to patients’ data. All patients underwent MRI for cardiac T2* evaluation. Cardiac T2* scores less than 20 ms were considered as iron overload. P wave dispersion, QTc interval, and the dispersions of QT and QTc were significantly prolonged in β-thalassemia major patients compared to controls. Interestingly, we found prolonged P waves, QT and T peak to end dispersions, T peak to end intervals, and increased T peak to end/QT ratios in patients with T2* greater than 20 ms. No significant correlation was observed between electrocardiographic parameters and cardiac T2* values and plasma ferritin levels. In conclusion, our study demonstrated that atrial depolarisation and ventricular repolarisation parameters are affected in β-thalassemia major patients and that these parameters are not correlated with cardiac iron load.

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Section: Electrocardiography and Echocardiographymentioning

confidence: 99%

Section: Electrocardiography and Echocardiographymentioning

confidence: 99%

Section: Electrocardiography and Echocardiographymentioning

confidence: 99%

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Evaluation of electrocardiographic markers of cardiac arrhythmic events and their correlation with cardiac iron overload in patients with β-thalassemia major

et al. 2020

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“…Therefore, Tp-e interval is a noninvasive scanning method for arrhythmogenesis and Tp-e interval can be approved as a crucial index in showing sudden cardiac death risk. There are studies in literature displaying that Tp-e/QT rate independent from Tp-e is a more reliable and stable index 34,35 . In a study that Tp-e/QT rate and its use were assessed, measurements were carried out in 60 healthy volunteers and it was shown that Tp-e interval decreased in a linear way with increase in heart rate.…”

Section: Discussionmentioning

confidence: 99%

Markers Of Arrhythmia In Patients With Left Ventricular Outflow Tract Stenosis And Coartation Of Aort

Sandal

Meşe²,

Özdemir³

et al. 2019

Cumhuriyet Medical Journal

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Arrhythmias due to congenital heart diseases are found to be the second most common cause of mortality after ischemic heart diseases in several studies. Coarctation of the aorta, hypertrophic cardiomyopathy and aort stenosis increase afterload of the left ventricle and as a result of this, they cause an increase in wall stress in the early and hypertophy of the wall in the late phase. This condition leads a corruption in ventricular and atrial conduction and predisposes to arrhythmias. In this study, we intended to examine the risks with indicators like P dis, QT dis, Tp-e for arrhythmias in diseases with left ventricular outflow tract stenosis in children. Method: 101 patients with with left ventricular outflow tract stenosis (coarctation of the aorta, idiopathic hypertrophic subaortic stenosis, hypertrophic cardiomyopathy and aortic stenosis) in pediatric age group who were diagnosed between 2008-2014 in Dr. Behçet Uz Children's Training and Research Hospital were included in this study. 110 healthy children were included in this study as a control group. Pdis, corrected QT, QT dis ve Tp-e and Tp-e /QT indices in both groups were were calculated and compared using standard 12-lead ECG. Results: P max, corrected QT, Pdis, QTdis, Tp-e and Tp-e/QT in patient group were found to be significantly higher than the control group. There was no difference between subgroups of patient group according to Pmax, corrected QT, P dis, QT dis, Tp-e and Tp-e/QT. There was also no difference between beta blocker users and non-users according to P max, corrected QT, P dis, QT dis, Tp-e and Tp-e/QT. Conclusions: High P max, corrected QT, P dis, QT dis, Tp-e and Tp-e/QT in the patient group showed the risk for ventricular arrhythmias and atrial fibrillation in patients with left ventricular outflow tract stenosis.

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“…HR increases in case of low hemoglobin levels in the blood. The increase in HR causes tachycardia and can trigger AVNRT via atrial ectopic beats (28) . Yo et al showed that aging affects the LF/HF ratio in healthy and hypertensive subjects (29) .…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Heart Rate Variability Parameters and Atrioventricular Nodal Reentrant Tachycardia

Aşkın¹,

Türkmen²

2018

Kosuyolu Heart Journal

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Introduction:Heart rate variability (HRV) is associated with sympathetic tone. Studies have disputed the interpretation of the low frequency (LF) and low/high frequency (LF/HF) ratio for the indication of sympathetic cardiac control and autonomic balance. This study aims to investigate the association between HRV parameters and atrioventricular nodal reentrant tachycardia (AVNRT) and observe the effect of autonomic nervous system on AVNRT. Patients and Methods:In total, 354 subjects with palpitations underwent the electrophysiological study (EPS). Most (71%; 253/354) patients had at least an ambulatory Holter ECG recording of 24 h. As a consequence of the exclusion criteria, 160 individuals were classified into two groups: control group (no arrhythmia induced, n= 90) and AVNRT group (n= 70).Results: Daytime and nighttime LF and LF/HF ratio were significantly higher in the AVNRT group (p< 0.05) than in the control group. Interestingly, daytime ultra-LF, very LF, and total power were significantly lower in the AVNRT group.Conclusion: AVNRT is associated with altered sympathovagal balance. Furthermore, increased LF and LF/ HF may be indicative of enhanced sympathetic activity in patients with AVNRT because of inhomogeneous ventricular activation via the slow accessory pathway.Giriş: Kalp hızı değişkenliği (HRV) sempatik ton ile ilişkilidir. Çalışmalar sempatik kardiyak kontrol ve otonom denge endikasyonu için düşük frekans (LF) ve düşük/yüksek frekans (LF/HF) oranının yorumlamasını tartışmışlardır. Bu çalışma, HRV parametreleri ile atriyoventriküler nodal reentrant taşikardi (AVNRT) arasındaki ilişkiyi araştırmayı ve otonomik sinir sisteminin AVNRT üzerindeki etkisini gözlemeyi amaçlamaktadır. Hastalar ve Yöntem:Çarpıntısı olan 354 olguya elektrofizyolojik çalışma yapıldı (EPS). Hastaların %71 (253/354)'i en az bir 24 saatlik ambulatuvar Holter elektrokardiyografi (EKG) kaydına sahipti. Dışlama kriterlerinin bir sonucu olarak, 160 birey iki gruba ayrıldı; kontrol grubu (aritmi indüklenmedi, n= 90) ve AVNRT grubu (n= 70).Bulgular: Gündüz ve gece LF ve LF/HF oranı AVNRT'de kontrollerden anlamlı derecede yüksekti (p< 0.05). İlginç olarak, gündüz ultra düşük frekans, çok düşük frekans ve toplam güç AVNRT'de anlamlı olarak düşüktü.Sonuç: AVNRT değişmiş sempatovagal denge ile ilişkilidir. Dahası, artmış LF ve LF/HF, AVNRT hastalarında yavaş aksesuar yolla homojen olmayan ventriküler aktivasyonun bir sonucu olarak artmış sempatik aktivitenin bir göstergesi olabilir.Anahtar Kelimeler: Atriyoventriküler nodal reentrant taşikardi; kalp hızı değişkenliği; düşük frekans; düşük/yüksek frekans Lütfü Aşkın

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Low Iron Stores in Otherwise Healthy Children Affect Electrocardiographic Markers of Important Cardiac Events

Cited by 10 publications

References 35 publications

Evaluation of electrocardiographic markers of cardiac arrhythmic events and their correlation with cardiac iron overload in patients with β-thalassemia major

Evaluation of electrocardiographic markers of cardiac arrhythmic events and their correlation with cardiac iron overload in patients with β-thalassemia major

Markers Of Arrhythmia In Patients With Left Ventricular Outflow Tract Stenosis And Coartation Of Aort

The Relationship Between Heart Rate Variability Parameters and Atrioventricular Nodal Reentrant Tachycardia

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