Low intrafamilial transmission of hepatitis C virus in Central Brazil

Martins, Regina Maria Bringel; Vanderborght, Bart; Rouzere, C. D.; Almeida, Valéria Correia de; Cardoso, Divina D. P.; Yoshida, Clara Fumiko Tachibana

doi:10.1590/s0036-46651994000600012

Cited by 1 publication

(1 citation statement)

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“…Intrafamilial transmission of HCV is considered as a nonsignificant route of transmission, and sexual transmission does not seem to play a role in the intrafamilial spread of HCV infection 18,19 . However, same studies have demonstrated significant anti-HCV prevalence rates in family members of patients with chronic HCV and/or in household contacts of anti-HCV-positive individuals 20 .…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B and C virus infection among Brazilian Amazon riparians

Oliveira

Silva

Santos

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Viral hepatitis is a major public health concern in Brazil. There are few past studies on this issue, especially among riparian communities. This study aims at determining the seroprevalence of viral hepatitis B and C in the riparian community of Pacuí Island, within the Cametá municipality of Pará State, Brazil. Moreover, this study aims to investigate the principal risk factors that this community is exposed to. Methods: The current study has accessed blood samples from 181 volunteers who have answered an epidemiological questionnaire. Analyses on serological markers have been tested with commercial ELISA kits for detecting HBsAg, total anti-HBc, anti-HBs, and anti-HCV. Within seroreactive patients for HCV, RT-PCR and line probe assay have been performed to identify the viral genotype. Results: In the serological marker analysis for hepatitis B, no reactivity for HBsAg, rate of 1.1% for total anti-HBc, and rate of 19.3% for anti-HBs have been observed. On hepatitis C, 8.8% seroprevalence has been found, in which 62.5% have gotten viral RNA. Among the risk factors studied, the following have been highlighted: non-use of condoms, sharing of cutting instruments, use of illicit drugs, and reports of family disease with HBV or HCV. Conclusions: The vaccination coverage against HBV is low, and the high prevalence of HCV within this community has been observed.

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Section: Discussionmentioning

confidence: 99%