Low-Intensity Pulsed Ultrasound Stimulates a Bone-Forming Response in UMR-106 Cells

Warden, Stuart J.; Favaloro, Jenny M.; Bennell, Kim L; McMeeken, Joan; Ng, Kong-Wah; Zajac, Jeffrey D; Wark, John D.

doi:10.1006/bbrc.2001.5412

Cited by 107 publications

(83 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are in agreement with previous animal studies on a sheep osteotomy which report that transosseous ultrasound application leads to an increase in bone matrix density and accelerated healing time [43]. Increased levels of bone density due to ultrasound are also reported in [27,51].…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

A mechano-regulatory model for bone healing predictions under the influence of ultrasound

Vavva

Grivas

Carlier

et al. 2015

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

“…The osteoblast density was also found to be about 10% greater in the ultrasound model from PFW1 to PFW4, which is also reported in previous experimental studies [50][51][52][53][54]. Nevertheless no safe conclusions can be drawn for this enhancement influence since this is downstream effect and has not been explicitly modeled herein.…”

Section: Discussionsupporting

confidence: 77%

A mechano-regulatory model for bone healing predictions under the influence of ultrasound

Vavva

Grivas

Carlier

et al. 2015

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

View full text Add to dashboard Cite

“…36 The decrease of those cytokines would lead to decline in osteoclast activity. 37,38 Although LIPUS might not directly stimulate osteoclasts, it was able to stimulate osteoblast activity 25,27 which, in turn, modulated osteoclast formation. 39 This was in agreement to our radiographical and pQCT analysis results that LIPUS advanced bone mineralization processes about 2 weeks as compared with sham during an The LIPUS and sham groups were compared with statistically significant difference.…”

Section: Discussionmentioning

confidence: 99%

Low intensity pulsed ultrasound accelerated bone remodeling during consolidation stage of distraction osteogenesis

Chan

Qin

Lee

et al. 2005

Journal Orthopaedic Research

View full text Add to dashboard Cite

Bone regeneration in distraction osteogenesis occurs under tensile stress with axial rhythmic distraction after osteotomy. In this study, we evaluated if the low intensity pulsed ultrasound (LIPUS) was also effective on enhancement of bone remodeling during consolidation stage of distraction osteogenesis. Open osteotomy of seventeen 18-week-old female New Zealand rabbit tibiae were performed. The distraction was applied with the rate of 1 mm per day. LIPUS (30 mW/cm 2 , 1.5 MHz) was delivered for 20 min per day during 4-week consolidation stage (n ¼ 10). The animals without treatment served as sham group (n ¼ 7). Plain X-ray, peripheral quantitative computational tomography (pQCT), and torsional test were performed. Results showed that smaller radiolucent interzone of LIPUS treatment group was gradually occupied by calcified tissue in plain X-ray at week 2. The bone mineral density (BMD) measured on radiographs increased by 9.18% in the LIPUS group. Bone mineral content (BMC), hard callus volume, and bone strength index (BSI) measured by pQCT were 83%, 116%, and 94%, respectively, in LIPUS group that were significantly greater than those of the controls. At the 4th week, LIPUS-treated callus showed the development of neocorticalization in the proximal and distal region. The BMC, hard callus volume, and BSI of LIPUS group decreased and was not significantly different from control. This was also confirmed by the maximum torque of LIPUS-treated callus (1424.2 AE 457.3 N Á mm) obtained at week 4, which did not differ from that of the sham group (1968.8 AE 895.1 N Á mm). In conclusion, the effective period of LIPUS treatment was at the initial stage of consolidation, with accelerated bone formation and remodeling. ß

show abstract

“…Many studies have shown that effective physical stimulation could induce a series of biological changes in osteoblasts, such as osteogenic effect (58,59), alteration of gene expression (44,60), and related signal pathway changes (44,61). The beneficial effects for enhanced osteoblast adhesion and migration may result from reorganization of actin cytoskeleton to a certain degree (23).…”

Section: Journal Of Biological Chemistry 26207mentioning

confidence: 99%

Optimal Intensity Shock Wave Promotes the Adhesion and Migration of Rat Osteoblasts via Integrin β1-mediated Expression of Phosphorylated Focal Adhesion Kinase

Chen

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background:The effects of extracorporeal shock wave (ESW) on adhesion and migration of osteoblasts have not been reported until now. Results: Optimal intensity shock wave promotes osteoblast adhesion and migration. Conclusion: ESW promotes the adhesion and migration of osteoblasts via integrin ␤1-mediated expression of phosphorylated FAK.Significance: This provides a mechanistic basis for improving the effectiveness of ESW treatment in fracture healing and tissue engineering.

show abstract

Low-Intensity Pulsed Ultrasound Stimulates a Bone-Forming Response in UMR-106 Cells

Cited by 107 publications

References 31 publications

A mechano-regulatory model for bone healing predictions under the influence of ultrasound

A mechano-regulatory model for bone healing predictions under the influence of ultrasound

Low intensity pulsed ultrasound accelerated bone remodeling during consolidation stage of distraction osteogenesis

Optimal Intensity Shock Wave Promotes the Adhesion and Migration of Rat Osteoblasts via Integrin β1-mediated Expression of Phosphorylated Focal Adhesion Kinase

Contact Info

Product

Resources

About