Low-Intensity Pulsed Ultrasound in the Treatment of Nonunions

Nolte, P A; Krans, A van der; Patka, P.; Janssen, Ignace M. C.; Ryaby, John P.; Albers, G. H. R.

doi:10.1097/00005373-200110000-00012

Cited by 253 publications

(153 citation statements)

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“…Low-intensity pulsed ultrasound (LIPUS) is a form of ultrasound that transmitted into connective tissues as an acoustic wave. As a non-invasive therapy, LIPUS has been used to promote fracture healing for 30 years, and is studied and applied in many clinical studies [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

“…It has been proved that LIPUS can promote formation of the medullary canal and cortex in a gap-healing model, which then leads to earlier restoration of the structural integrity of the healing site 11 . Many clinical studies indicate that LIPUS can enhance the healing of fresh fractures, delayed unions, nonunions, distraction osteogenesis and congenital pseudoarthroses 7,8,12,13 .…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound treatment for accelerating fracture healing of the distal radius. A control study

Liu¹,

Wei²,

Kuang³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To investigate the accelerating effects of low-intensity pulse ultrasound stimulation (LIPUS) on the fracture healing of distal radius. METHODS:A total of 81 patients with distal radius fracture were randomly divided into two groups: the ultrasound treatment group and the control group. Patients in the ultrasound treatment group were immobilized in a below-elbow cast and received LIPUS treatment 15 min/day, while the control group were immobilized by a plaster support and cast. The patients were followed up every week and took X-ray films. The initial and healed X-ray films and the gray value of fracture site were analyzed by Photoshop software. The effect of reposition was evaluated based upon Steward recommended by Dienst, combining with Aro's measuring method. RESULTS:Clinical fracture healing time in ultrasound group was significantly shorter than that in the control group (32.04 ± 2.58d vs.40.75 ± 5.12d, p <0.01). In addition, the grey value changes of fracture sites of the ultrasound group were much higher than that of the control group. The reposition effects of fracture healing had no difference between the two groups (p >0.05). CONCLUSION:Low-intensity pulse ultrasound stimulation could accelerate fracture healing of the distal radius and promote local bone formation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrasound treatment for accelerating fracture healing of the distal radius. A control study

Liu¹,

Wei²,

Kuang³

et al. 2014

Acta Cir. Bras.

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show abstract

“…[34,35] Low-intensity pulsed US waves have therapeutic effects on different disorders such as bone fracture healing, osteoporosis, and pain relieving. [36][37][38][39][40][41] Clinical evidence shows the efficiency of very low-intensity US on bone and soft tissue healing. At low intensities, thermal effects are not likely the responsible mechanism of action.…”

Section: Biological Interactions Of Usmentioning

confidence: 99%

Untitled

Rashidi

2017

IJGP

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Objective: Ultrasound (US) waves have unique characteristics that making them promising option for treatment of different soft tissue injuries particularly wounds. The mechanisms of actions of this technique in the treatment of soft tissue are not fully understood. This paper aimed to comprehensively review the biological interactions and mechanism of action of US waves in the treatment of chronic wounds. Methods: The databases of PubMed (1990PubMed ( -2016, EMBASE (1990EMBASE ( -2016, Web of Sciences (1990), and Google Scholar (1980 were searched using the set terms "US waves" and "wound treatment," "mechanism of action" and "soft tissue injuries," and "biologi8cal interaction." The title and abstract of the collected results were reviewed by two authors, and the relevant papers were selected for further evaluations. Results: The mechanisms of action depend on the US physical parameters as well as exposure factors including duration and injury type. The main mechanisms of US waves for wound healing are enhancing the rate of inflammatory phase, stimulating fibroblasts to secrete collagen, enhancing extensibility of collagen, circulation, pain threshold, enzymatic activity, permeability of cell membrane, and accelerating nerve conduction. Conclusion: The therapeutic effects of US depend on dose (W/cm 2 ) and dosage (frequency of application). Low US frequencies show more therapeutic efficiency in wound healing compared with high frequencies.

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“…Neither has clearly demonstrated the minimal clinical effect in acceleration of 6 weeks for radiographic fracture healing that most of our respondents would consider clinically important. Surgeons may use bone stimulators to heal nonunions, and there is some preliminary evidence to suggest a possible effect (Sharrard 1990, Nolte et al 2001, Simonis et al 2003). …”

Section: Current Evidence and Recommendations For Management Of Tibiamentioning

confidence: 99%

Current management of tibial shaft fractures: A survey of 450 Canadian orthopedic trauma surgeons

et al. 2008

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Low-Intensity Pulsed Ultrasound in the Treatment of Nonunions

Abstract: Noninvasive ultrasound therapy can be useful in the treatment of challenging, established nonunions.

Cited by 253 publications

References 21 publications

Ultrasound treatment for accelerating fracture healing of the distal radius. A control study

Ultrasound treatment for accelerating fracture healing of the distal radius. A control study

Untitled

Current management of tibial shaft fractures: A survey of 450 Canadian orthopedic trauma surgeons

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