Low-intensity pulsed ultrasound for non-union treatment: A 14-case series evaluation

Hemery, Xavier; Ohl, Xavier; Saddiki, R.; Barresi, Laurent; Dehoux, E.

doi:10.1016/j.otsr.2010.09.016

Cited by 21 publications

(11 citation statements)

References 22 publications

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“…The HR of 86.2% we report is consistent with other reports of LIPUS treatment for nonunion [7,16,[22][23][24][25][26][27]. Nine previous studies of LIPUS for nonunion have reported HRs ranging from 73% to 100% [7,16,19,[22][23][24][25][26][27], with a median HR of 86%.…”

Section: Discussionsupporting

confidence: 89%

“…Nine previous studies of LIPUS for nonunion have reported HRs ranging from 73% to 100% [7,16,19,[22][23][24][25][26][27], with a median HR of 86%. Our results are also consistent with a systematic review of LIPUS for nonunions, which reported an HR of 87% in 594 nonunions from 8 studies, with a mean fracture age of 22.2 months and mean heal time of 4.8 months [28].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of chronic (>1 year) fracture nonunion: Heal rate in a cohort of 767 patients treated with low-intensity pulsed ultrasound (LIPUS)

Zura¹,

Rocca²,

Mehta³

et al. 2015

Injury

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Treatment of chronic (>1 year) fracture nonunion: Heal rate in a cohort of 767 patients treated with low-intensity pulsed ultrasound (LIPUS)

Zura¹,

Rocca²,

Mehta³

et al. 2015

Injury

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show abstract

“…A total of 4611 references were evaluated ( Fig. 1) to yield 10 eligible references on LIPUS treatment of human fracture nonunions [4,9,[25][26][27][28][29][30][31][32]. Three references [33][34][35] were obtained outside the scope of the PubMed search, while 4608 references were found by PubMed.…”

Section: Search Processmentioning

confidence: 99%

“…We repeated the pooled analysis after excluding studies that were regarded as weaker in methodological quality [26,30,34,35]. These studies had been assigned a score 6 in the MINORS scale.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis

Leighton

Watson

Giannoudis

et al. 2017

Injury

123

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LIPUS treatment can be an alternative to surgery for established nonunions. Given that no spontaneous healing of established nonunions is expected, and that it is challenging to test the efficacy of LIPUS for nonunion by randomized clinical trial, findings are compelling. LIPUS may be most useful in patients for whom surgery is high risk, including elderly patients at risk of delirium, or patients with dementia, extreme hypertension, extensive soft-tissue trauma, mechanical ventilation, metabolic acidosis, multiple organ failure, or coma. With an overall average success rate for LIPUS >80% this is comparable to the success of surgical treatment of non-infected nonunions.

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“…Four studies evaluating the ultrasound therapy were taken into account [40-43]. The total number of patients undergoing ultrasound was 104 (71 males and 33 females) with an average age of 38.48 years at the time of treatment.…”

Section: Resultsmentioning

confidence: 99%

Tissue Engineered Strategies for Pseudoarthrosis

Longo¹,

Trovato²,

Loppini³

et al. 2012

TOORTHJ

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Numerous classification systems of non-union have been proposed based on: presence or absence of infection, radiographic features, clinical findings, biologic activity, location and shape. The management of pseudarthrosis is strongly related to the type of non-union (infected versus uninfected, atrophic versus hypertrophic). Surgical management of pseudarthrosis is generally effective with a success rate ranging from 75 to 100%. Nevertheless, in a relatively high number of instances several combined treatments are required for the fracture healing. The current gold standard to stimulate the bone regeneration is represented by the revision surgery with the application of autologous bone grafts. However, several approaches have been described to promote and enhance the bone tissue regeneration, including extracorporeal shock wave therapy (ESWT), ultrasound, electromagnetic, bone morphogenic proteins (BMPs) and platelet-rich-plasma (PRP).The aim of the present study was to perform a systematic review of the literature evaluating the current therapies to promote and enhance the bone tissue healing. The systematic review was performed according to PRISMA guidelines with a PRISMA checklist and algorithm.Limitations of the present systematic review are mainly related to the scanty quality of the studies available in the literature. Although the therapies previously described for the management of patients with non-unions seems to be effective, the limitations of the included studies, especially the extensive clinical heterogeneity, make not possible to provide clear recommendations regarding the application of these approaches. The problems remain the need to better understand the most effective treatment options, subject to surgical stabilization as a first step.

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Low-intensity pulsed ultrasound for non-union treatment: A 14-case series evaluation

Abstract: Retrospective study, level IV.

Cited by 21 publications

References 22 publications

Treatment of chronic (>1 year) fracture nonunion: Heal rate in a cohort of 767 patients treated with low-intensity pulsed ultrasound (LIPUS)

Treatment of chronic (>1 year) fracture nonunion: Heal rate in a cohort of 767 patients treated with low-intensity pulsed ultrasound (LIPUS)

Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis

Tissue Engineered Strategies for Pseudoarthrosis

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