Low-Intensity Exercise Exerts Beneficial Effects on Plasma Lipids via PPARγ

Butcher, Lee; Thomas, Andrew W.; Backx, Karianne; Roberts, Annette; Webb, Richard; Morris, Keith

doi:10.1249/mss.0b013e31816c091d

Cited by 116 publications

(130 citation statements)

References 37 publications

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“…Irisin may modulate the PPARα signaling pathway, a key regulator of lipid metabolism that coordinates fat oxidation through a thermogenesis mechanism (5). Previous studies have reported an increase in PPARα following physical training (26,49,50). It seems practicable that endurance training and resistance training are beneficial in adipose metabolism by elevating the expression of FNDC5 and the subsequent increase in PPARα expression stimulation.…”

Section: Discussionmentioning

confidence: 96%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain. Objective(s). This study aims at comparing the effects of resistance and endurance training on FNDC5 (the precursor of irisin myokine) gene expression in male rat liver tissues.. Methods. Fifteen Wistar male rats (aged 10-12 weeks with an average weight of 331.8 ±63.09 gr) were used. After being taken to the animals' laboratory, the subjects were randomly assigned to three equal groups viz: control (N=5), endurance (N=5) and resistance (N=5). For the purpose of tissue sampling, all these subjects were anesthetized 72 hours after the experiment had been completed. The liver tissue was immediately removed and then quickly frozen in liquid nitrogen and kept at a temperature of -80o C until RNA extraction. FNDC5 relative gene expression was identified by Real-time PCR method. Results. Data analysis revealed a significant difference in FNDC5 gene expression among the groups (P=0.008, Chi Square=31.791). No significant difference was observed between the resistance training and endurance training groups in FNDC5 gene expression, though (P=0.959). Conclusion. It can be established that both resistance and endurance training can similarly affect the production and secretion of exerciseinduced myokines, including FNDC5 irisin, which can in turn protect against obesity and its impacts on the liver tissue by stimulating the process of browning of white fat.

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Section: Discussionmentioning

confidence: 96%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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“…This suggests that the improvements observed in AIx in the current study (which suggest an improvement in endothelial function) may also occur as a result of exercise-induced activation of PPARγ. Thus, while due to an association with increased risk of death from CV causes [51], the prescription of RSG has fallen dramatically in recent years [52], exercise may provide a safe alternative to RSG as a method of inducing beneficial PPARγ-dependent effects [36,37]. Therefore, with regard to the current study's findings, we propose that an exerciseinduced activation of the nuclear receptor PPARγ may cause the observed down-regulation in the expression of the elastin-degrading gene MMP-9 (and also possibly improve endothelial function), which in turn may ameliorate physical inactivity-related vascular remodelling.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, given previous reports that participation in exercise is associated with generation of natural ligands for the nuclear receptor protein peroxisome proliferator-activated receptor-gamma (PPARγ) within the vasculature [36,37], that pharmacological activators of the nuclear receptor PPARγ are associated with decreased MMP-9 secretion from human monocytes [38], and that PPARγ may bring about this effect by antagonistic transrepression at nuclear factor-kappa Beta response elements (NFkB-RE) and activator protein-1 sites [39,40], we performed bioinformatics screens of the human MMP-9 promoter (accession code: NG_011468.1) for peroxisome proliferator response elements (PPRE), NFkB-RE and AP-1 consensus sequences. No PPREs were found within ~5Kbp of the MMP-9 start site, but sequences were found resembling the reported consensus sequences for NFkB-RE [41] and AP-1 [42] at positions -4076bp, -637bp, -408bp, -349bp; and positions -1680bp, -556bp, respectively.…”

Section: Walk Registers and Ipaq Met-minutes Revealed That 19 Of The 36mentioning

confidence: 99%

Matrix Metalloproteinase-9 and Augmentation Index are Reduced with an 8-Week Green-Exercise Walking Programme

Thompson

Webb²,

Hewlett³

et al. 2013

J Hypertens

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“…PGC-1 has been shown to mediate the beneficial effects of exercise 38) . Butcher et al reported that 8-week low-intensity exercise significantly increased leukocyte mRNA expression for PPAR , LXR, and ABCA1, and plasma HDL-C in sedentary adults 39) . These suggest that aerobic exercise training might play an important role for affect HDL transport and/or metabolism through PPARs, LXR, and ABC A1.…”

Section: Correlation Coefficients Between Cholesterol Efflux Capacitymentioning

confidence: 99%

Beneficial Effects of Exercise-Based Cardiac Rehabilitation on High-Density Lipoprotein-Mediated Cholesterol Efflux Capacity in Patients with Acute Coronary Syndrome

Koba

Ayaori

Uto‐Kondo

et al. 2016

JAT

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Aim: Recent studies reported that low high-density lipoprotein (HDL)-mediated cholesterol efflux capacity rather than low HDL cholesterol (HDL-C) is strongly associated with the increased risk for coronary artery disease. It remains unclear whether exercised-based cardiac rehabilitation (CR) can increase HDL cholesterol efflux capacity. Method: This study is a retrospective analysis of stored serum from patients with acute coronary syndrome (ACS) who participated in outpatient CR program following successful percutaneous coronary intervention. We employed a cell-based cholesterol efflux system including the incubation of 3 H-cholesterol labeled macrophages with apolipoprotein B-depleted serum at the onset or early phase of ACS and at 6-month follow-up periods in 57 male and 11 female patients with ACS. Cardiopulmonary exercise tests were performed at the beginning and end of CR program. Result: Fifty-seven patients completed the CR program. Compared with patients who dropped out from CR program (non-CR group), CR participants showed marked amelioration in serum lipid levels, increased efflux capacity, and improved exercise capacity. Spearman's rank correlation coefficient analysis revealed that the percent increases of efflux capacity were significantly associated with the percent increases in HDL-C ( 0.598, p 0.0001) and apolipoprotein A1 ( 0.508, p 0.0001), whereas no association between increases in efflux capacity and increases in cardiopulmonary fitness was observed. Increases in cholesterol efflux capacity were not seen in patients who continued smoking and those who did not achieve all risk factor targets and higher exercise tolerance. Conclusion: CR can markedly increase both HDL-C and HDL cholesterol efflux capacity. These results suggest that CR is a very useful therapy for reverse cholesterol transport and secondary prevention.

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Low-Intensity Exercise Exerts Beneficial Effects on Plasma Lipids via PPARγ

Abstract: We propose that the net effect of these changes may be to increase oxLDL uptake, to stimulate RCT, and thus to promote clearance of proatherogenic lipids from the vasculature, ultimately contributing to the cardiovascular benefits of low-intensity aerobic exercise.

Cited by 116 publications

References 37 publications

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Matrix Metalloproteinase-9 and Augmentation Index are Reduced with an 8-Week Green-Exercise Walking Programme

Beneficial Effects of Exercise-Based Cardiac Rehabilitation on High-Density Lipoprotein-Mediated Cholesterol Efflux Capacity in Patients with Acute Coronary Syndrome

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