Low Inherent Sensitivity to the Intoxicating Effects of Ethanol in Rhesus Monkeys with Low <scp>CSF</scp> Concentrations of the Serotonin Metabolite 5‐Hydroxyindoleacetic Acid

Wood, Elizabeth K.; Kruger, Ryno; Bennion, Angus; Cooke, Bradley M.; Lindell, Stephen G.; Schwandt, Melanie L.; Goldman, David; Barr, Christina S.; Suomi, Stephen J.; Higley, J. Dee

doi:10.1111/acer.13552

Cited by 4 publications

(4 citation statements)

References 54 publications

(59 reference statements)

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“…These findings showing that levels of early life cisternal CSF monoamine metabolites are stable interindividually, beginning early in life suggest that risk for high alcohol intake could be measured early in life via assessments of CNS monoamine activity and that initial drinking patterns in adolescence may be, in part, mediated by the monoamine system. This postulate is supported in part by a recent study showing that low baseline CSF 5‐HIAA concentrations are associated with low intoxication in adolescent rhesus monkeys 34 …”

Section: Discussionmentioning

confidence: 77%

“…This postulate is supported in part by a recent study showing that low baseline CSF 5-HIAA concentrations are associated with low intoxication in adolescent rhesus monkeys. 34 These findings also suggest that individual differences in the motivation for alcohol intake may be modulated by individual differences in monoamine concentrations. Indeed, the risk for alcohol abuse may, in part, have its basis in naturally occurring individual differences in CNS monoamine functioning, as well as in alcohol-induced monoamine concentrations and alcohol-induced changes in central monoamine functioning.…”

Section: Discussionmentioning

confidence: 88%

“…First, it plays a well-established role in inhibiting impulsive behaviour 37,38 via the frontal cortex. 39 Second, low central serotonin is associated with decreased alcohol sensitivity 34 and impaired impulse control. 12 As reported elsewhere, subjects with impaired CNS serotonin functioning are less sensitive to alcohol, and they consume more to experience its reinforcing effects.…”

Section: Discussionmentioning

confidence: 99%

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Central nervous system monoamine metabolite response to alcohol exposure is associated with future alcohol intake in a nonhuman primate model (Macaca mulatta)

et al. 2022

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It is widely held that the central monoamine neurotransmitters modulate alcohol intake. Few studies, however, directly assess the relationship between baseline and alcohol-induced monoamine turnover, as well as the change from baseline, as predictors of alcohol intake. Using a nonhuman primate model, this study investigates baseline, alcohol-induced and alcohol-induced change in monoamine activity and their relationship with alcohol intake. Alcohol-naïve, adolescent rhesus macaques (Macaca mulatta, N = 114) were administered a standardized intravenous bolus of alcohol solution (16.8%, v/v) on two occasions, approximately 1 month apart. One month prior to and 1 h following each alcohol infusion, cisternal cerebrospinal fluid (CSF) was obtained and assayed for monoamine metabolite concentrations. Approximately 6-7 months later, subjects were allowed unfettered access to an aspartamesweetened alcohol solution (8.4%, v/v) for 1 h/day, 5 days/week, over 5-7 weeks.Results showed strong positive correlations between baseline and post-infusion CSF monoamine metabolite concentrations, indicating a trait-like response. Low baseline and post-infusion serotonin and dopamine metabolite concentrations and a smaller change in serotonin and dopamine metabolites from one infusion to the next were associated with higher alcohol intake. Low baseline and post-infusion norepinephrine metabolite concentrations predicted high alcohol intake, but unlike the other monoamines, a greater change in norepinephrine metabolite concentrations from one infusion to the next was associated with higher alcohol intake. These findings suggest that individual differences in naturally occurring and alcohol-induced monoamine activity, as well as the change between exposures, are important modulators of initial alcohol consumption and may play a role in the risk for excessive alcohol intake.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Central nervous system monoamine metabolite response to alcohol exposure is associated with future alcohol intake in a nonhuman primate model (Macaca mulatta)

et al. 2022

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“…For further investigations it is worth to determine the level of 5-hydroxyindoleacetic acid in a 24-h urine collection. It is a stable metabolite of serotonin and by this way its level can be determined indirectly[30]. It was not done in our present research.…”

Section: Discussionmentioning

confidence: 93%

Efficacy of Detoxsan^®powder on diarrhea caused by gastrointestinal neuroendocrine tumors

Langbein

Dathe²,

Deuerling

et al. 2019

WJG

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BACKGROUND Patients with neuroendocrine tumors (NETs) of the gastrointestinal tract suffer frequently from chronic diarrhea. A well characterized medical advice containing zeolite (Detoxsan ® powder) was applied to patients suffered from therapy-refractory diarrhea either by its frequency or by watery stool, despite receiving standard pharmacotherapy according to the guidelines for carcinoid syndrome and comorbidities. Detoxsan ® powder acts as an adsorbent and might reduce significantly symptoms of diarrhea in patients suffering from NETs. AIM To overcome the therapy-refractory diarrhea of patients with NETs by the zeolite containing medical advice Detoxsan ® powder. METHODS A total of 20 patients (12 female and 8 male) suffering from diarrhea either by its frequency or from watery stool caused by NETs were included. In each patient, the diagnosis had been confirmed by histology and somatostatin receptors expression proven by positron emission tomography/computed tomography using Ga-68-labeled somatostatin analogs. All patients received standard-of-care pharmacotherapy and were additionally given Detoxsan ® powder as an extemporaneous drug containing 90% natural Cuban zeolite and 10% magnesium aspartate. Recommended daily dosage ranges between 3 g once to three times per day. Each day dose and bowel movements were documented by the patients themselves in a pre-defined table. Additionally to the bowel movements quantitative determinations of serotonin, urea, creatinine and single ions were performed within the serum of the patients by commercially available equipment used as a matter of routine in the clinic. RESULTS All patients enrolled in this pilot study did not only suffer from NETs, but also from comorbidities and treatment-resistant diarrhea. There was insufficient control of diarrhea, most probably due to the secretion of hormones like serotonin produced by the slowly growing and highly differentiated NETs. All patients only took Detoxsan ® powder as an antidiarrheal drug. In general, response effects need several days to become perceptible and require an intake of Detoxsan ® powder for an extended time period or intermittently, if persisting stabilization of bowel movements could not be achieved. A correlation between NET grade, part and size of bowel resection and functionality of the tumor could not be demonstrated. Therefore, diarrhea seemed to be based on the metabolic activity of the well-differentiated NETs, which eventually led to treatment resistance. In summary, 14 out of the 20 patients (70%) declared to be very content with using Detoxsan ® powder and observed a significant reduction of diarrhea, while the effective dose and intake period that resulted in a symptom relief varied individually. ...

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The role of serotonin in alcohol use and abuse

Müller

Schumann

Kornhuber

et al. 2020

Handbook of Behavioral Neuroscience

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Low Inherent Sensitivity to the Intoxicating Effects of Ethanol in Rhesus Monkeys with Low CSF Concentrations of the Serotonin Metabolite 5‐Hydroxyindoleacetic Acid

Cited by 4 publications

References 54 publications

Central nervous system monoamine metabolite response to alcohol exposure is associated with future alcohol intake in a nonhuman primate model (Macaca mulatta)

Central nervous system monoamine metabolite response to alcohol exposure is associated with future alcohol intake in a nonhuman primate model (Macaca mulatta)

Efficacy of Detoxsan^®powder on diarrhea caused by gastrointestinal neuroendocrine tumors

The role of serotonin in alcohol use and abuse

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Low Inherent Sensitivity to the Intoxicating Effects of Ethanol in Rhesus Monkeys with Low CSF Concentrations of the Serotonin Metabolite 5‐Hydroxyindoleacetic Acid

Cited by 4 publications

References 54 publications

Central nervous system monoamine metabolite response to alcohol exposure is associated with future alcohol intake in a nonhuman primate model (Macaca mulatta)

Central nervous system monoamine metabolite response to alcohol exposure is associated with future alcohol intake in a nonhuman primate model (Macaca mulatta)

Efficacy of Detoxsan®powder on diarrhea caused by gastrointestinal neuroendocrine tumors

The role of serotonin in alcohol use and abuse

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Product

Resources

About

Efficacy of Detoxsan^®powder on diarrhea caused by gastrointestinal neuroendocrine tumors